KEGG   PATHWAY: sly00260
Entry
sly00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Solanum lycopersicum (tomato)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sly00260  Glycine, serine and threonine metabolism
sly00260

Module
sly_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sly00260]
sly_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sly00260]
sly_M00555  Betaine biosynthesis, choline => betaine [PATH:sly00260]
sly_M00621  Glycine cleavage system [PATH:sly00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Solanum lycopersicum (tomato) [GN:sly]
Gene
101258399  aspartokinase 2, chloroplastic isoform X2 [KO:K00928] [EC:2.7.2.4]
101258465  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
101264587  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
101258686  uncharacterized protein LOC101258686 [KO:K00133] [EC:1.2.1.11]
101248664  homoserine kinase [KO:K00872] [EC:2.7.1.39]
101260521  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
101244777  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
101247807  probable low-specificity L-threonine aldolase 1 isoform X2 [KO:K01620] [EC:4.1.2.48]
101250548  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
101254439  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
101256090  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
101264818  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
101259725  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
101267301  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
101263138  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
101055519  Hop-interacting protein THI032 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100191110  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
101251910  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
101243827  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
101247124  uncharacterized protein LOC101247124 [KO:K01834] [EC:5.4.2.11]
101265817  uncharacterized protein LOC101265817 isoform X4 [KO:K01834] [EC:5.4.2.11]
101265096  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
101248497  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
101244755  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
101266918  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101246616  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101254848  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101254553  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
101264434  phosphoserine phosphatase, chloroplastic isoform X1 [KO:K01079] [EC:3.1.3.3]
101253862  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
543808  cuAO; copper amine oxidase precursor [KO:K00276] [EC:1.4.3.21]
101266123  uncharacterized protein LOC101266123 [KO:K00276] [EC:1.4.3.21]
101253199  uncharacterized protein LOC101253199 [KO:K00276] [EC:1.4.3.21]
101254319  uncharacterized protein LOC101254319 [KO:K00276] [EC:1.4.3.21]
101263760  LOW QUALITY PROTEIN: primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
101260070  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
101249137  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
101245293  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
101246429  dihydrolipoyl dehydrogenase 1, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
101245444  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
544237  dihydrolipoamide dehydrogenase precursor [KO:K00382] [EC:1.8.1.4]
101257194  ADH11A4a; glycine cleavage system H protein, mitochondrial [KO:K02437]
101258615  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
101244882  glycine cleavage system H protein, mitochondrial [KO:K02437]
101247011  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101268729  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101251709  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
101265236  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
101261534  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
101249833  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
100301929  amadh2; aminoaldehyde dehydrogenase 2 [KO:K00130] [EC:1.2.1.8]
101253497  ADH10A9; putative betaine aldehyde dehyrogenase [KO:K00130] [EC:1.2.1.8]
101252968  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101265751  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
543983  TD2; threonine dehydratase 2 biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
101244823  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
100037737  chloroplast threonine deaminase 1 precursor [KO:K01754] [EC:4.3.1.19]
101261640  serine racemase-like [KO:K12235] [EC:5.1.1.18]
101252608  serine racemase [KO:K12235] [EC:5.1.1.18]
101252307  serine racemase-like [KO:K12235] [EC:5.1.1.18]
101255433  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
101256422  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
101256529  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
101249965  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
101254921  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
101261400  uncharacterized protein LOC101261400 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sly00010  Glycolysis / Gluconeogenesis
sly00020  Citrate cycle (TCA cycle)
sly00230  Purine metabolism
sly00250  Alanine, aspartate and glutamate metabolism
sly00270  Cysteine and methionine metabolism
sly00290  Valine, leucine and isoleucine biosynthesis
sly00300  Lysine biosynthesis
sly00330  Arginine and proline metabolism
sly00460  Cyanoamino acid metabolism
sly00470  D-Amino acid metabolism
sly00564  Glycerophospholipid metabolism
sly00600  Sphingolipid metabolism
sly00620  Pyruvate metabolism
sly00630  Glyoxylate and dicarboxylate metabolism
sly00640  Propanoate metabolism
sly00860  Porphyrin metabolism
sly00920  Sulfur metabolism
KO pathway
ko00260   
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