KEGG   PATHWAY: snk00260
Entry
snk00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces nitrosporeus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
snk00260  Glycine, serine and threonine metabolism
snk00260

Module
snk_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:snk00260]
snk_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:snk00260]
snk_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:snk00260]
snk_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:snk00260]
snk_M00621  Glycine cleavage system [PATH:snk00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces nitrosporeus [GN:snk]
Gene
CP967_18370  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CP967_18375  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CP967_23010  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CP967_10130  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CP967_10120  homoserine kinase [KO:K00872] [EC:2.7.1.39]
CP967_10125  threonine synthase [KO:K01733] [EC:4.2.3.1]
CP967_14885  threonine synthase [KO:K01733] [EC:4.2.3.1]
CP967_31510  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CP967_09545  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CP967_10075  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CP967_10425  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CP967_04010  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CP967_15295  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
CP967_09335  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CP967_14385  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CP967_27290  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CP967_05595  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
CP967_05600  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
CP967_06330  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
CP967_23895  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
CP967_29705  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
CP967_09535  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
CP967_25165  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CP967_09540  gcvH; glycine cleavage system protein GcvH [KO:K02437]
CP967_02335  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
CP967_03965  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CP967_08235  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CP967_08265  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CP967_29365  class I SAM-dependent methyltransferase [KO:K18896] [EC:2.1.1.156]
CP967_20725  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CP967_16830  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
CP967_09550  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CP967_12030  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
CP967_17730  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
CP967_25900  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CP967_25895  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CP967_27025  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CP967_07680  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
CP967_15065  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CP967_27030  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
CP967_27020  ectoine synthase [KO:K06720] [EC:4.2.1.108]
CP967_27015  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
CP967_26040  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
snk00010  Glycolysis / Gluconeogenesis
snk00020  Citrate cycle (TCA cycle)
snk00230  Purine metabolism
snk00250  Alanine, aspartate and glutamate metabolism
snk00270  Cysteine and methionine metabolism
snk00290  Valine, leucine and isoleucine biosynthesis
snk00300  Lysine biosynthesis
snk00330  Arginine and proline metabolism
snk00460  Cyanoamino acid metabolism
snk00470  D-Amino acid metabolism
snk00564  Glycerophospholipid metabolism
snk00600  Sphingolipid metabolism
snk00620  Pyruvate metabolism
snk00630  Glyoxylate and dicarboxylate metabolism
snk00640  Propanoate metabolism
snk00680  Methane metabolism
snk00860  Porphyrin metabolism
snk00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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