KEGG   PATHWAY: spu00053
Entry
spu00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Strongylocentrotus purpuratus (purple sea urchin)
Class
Metabolism; Carbohydrate metabolism
Pathway map
spu00053  Ascorbate and aldarate metabolism
spu00053

Module
spu_M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:spu00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
579664  UDP-glucose 6-dehydrogenase isoform X1 [KO:K00012] [EC:1.1.1.22]
583615  probable glucuronokinase 2 [KO:K16190] [EC:2.7.1.43]
578573  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
592958  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
593427  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
592078  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
578628  UDP-glucuronosyltransferase 1-8 [KO:K00699] [EC:2.4.1.17]
764059  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
755955  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
115922271  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
580284  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
578924  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
589187  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
582057  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
115920758  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
581862  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
100893272  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
592931  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
582456  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
100892570  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
586865  UDP-glucuronosyltransferase 2C1 isoform X2 [KO:K00699] [EC:2.4.1.17]
115917912  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
100888948  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
575220  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
100893671  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
105444861  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
100893231  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
115918426  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
581792  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
115919873  UDP-glucuronosyltransferase 1-4-like [KO:K00699] [EC:2.4.1.17]
581841  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
580846  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
592305  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
582989  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
582390  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
591823  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
105439455  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
100889303  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
578623  UDP-glucuronosyltransferase 2B1 isoform X3 [KO:K00699] [EC:2.4.1.17]
115924776  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
593640  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
580789  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
115925289  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
582820  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
115926435  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
105444322  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
115926442  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
115926443  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
115926445  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
115926714  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
584438  UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
575738  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
105443756  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
581741  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
581857  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
585947  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
100892045  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
589827  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
591053  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
586804  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
115928711  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
100888011  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
115918951  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
575689  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
593425  inositol oxygenase [KO:K00469] [EC:1.13.99.1]
587281  aldo-keto reductase family 1 member A1-B [KO:K00002] [EC:1.1.1.2]
575038  regucalcin [KO:K01053] [EC:3.1.1.17]
754557  regucalcin [KO:K01053] [EC:3.1.1.17]
764246  L-gulonolactone oxidase [KO:K00103] [EC:1.1.3.8]
115917982  L-gulonolactone oxidase-like [KO:K00103] [EC:1.1.3.8]
100888205  L-gulonolactone oxidase-like [KO:K00103] [EC:1.1.3.8]
581754  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
581706  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
105445554  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
593236  aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
105445170  aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
756945  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
588376  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
580956  4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
583864  4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
115918585  4-trimethylaminobutyraldehyde dehydrogenase-like [KO:K00149] [EC:1.2.1.47 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
spu00020  Citrate cycle (TCA cycle)
spu00040  Pentose and glucuronate interconversions
spu00051  Fructose and mannose metabolism
spu00520  Amino sugar and nucleotide sugar metabolism
spu00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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