KEGG PATHWAY: spu00590

KEGG

PATHWAY: spu00590

Entry

spu00590                    Pathway

Name

Arachidonic acid metabolism - Strongylocentrotus purpuratus (purple sea urchin)

Class

Metabolism; Lipid metabolism

Pathway map

Arachidonic acid metabolism

Other DBs

GO:

Organism

Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]

Gene

phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]

phospholipase A2 [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-I-like [KO:K01047] [EC:3.1.1.4]

phospholipase A2 [KO:K01047] [EC:3.1.1.4]

uncharacterized protein LOC100889667 [KO:K01047] [EC:3.1.1.4]

phospholipase A2 [KO:K01047] [EC:3.1.1.4]

phospholipase A2 [KO:K01047] [EC:3.1.1.4]

group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]

uncharacterized protein LOC105445152 [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-I-like [KO:K01047] [EC:3.1.1.4]

phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 BpirPLA2-I-like [KO:K01047] [EC:3.1.1.4]

basic phospholipase A2 pseudexin A chain-like [KO:K01047] [EC:3.1.1.4]

basic phospholipase A2 pseudexin A chain-like [KO:K01047] [EC:3.1.1.4]

neutral phospholipase A2 3 [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 BpirPLA2-I [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-II [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-I [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 natratoxin [KO:K01047] [EC:3.1.1.4]

phospholipase A2-like [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-II-like [KO:K01047] [EC:3.1.1.4]

phospholipase A2-like [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 natratoxin-like [KO:K01047] [EC:3.1.1.4]

neutral phospholipase A2 3-like [KO:K01047] [EC:3.1.1.4]

basic phospholipase A2 nigroxin A-like [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2-like [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-II [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-II-like [KO:K01047] [EC:3.1.1.4]

phospholipase A2 AP-PLA2-I [KO:K01047] [EC:3.1.1.4]

phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]

acidic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]

85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]

phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]

phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]

phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]

phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]

phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]

prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]

carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

prostamide/prostaglandin F synthase-like [KO:K15717] [EC:1.11.1.20]

15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]

S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]

probable glutathione S-transferase 6 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]

hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11 isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin 4 isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin 4-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]

glutathione S-transferase 1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

glutathione S-transferase 3 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

S-crystallin SL11 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

LOW QUALITY PROTEIN: allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]

allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]

allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]

allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]

arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]

arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]

arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]

allene oxide synthase-lipoxygenase protein isoform X1 [KO:K00461] [EC:1.13.11.34]

arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]

arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]

arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]

allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]

leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]

prostaglandin reductase-3 [KO:K07119] [EC:1.3.1.48]

prostaglandin reductase-3-like [KO:K07119] [EC:1.3.1.48]

prostaglandin reductase-3-like [KO:K07119] [EC:1.3.1.48]

prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]

prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]

prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]

prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]

prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]

prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]

prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]

prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]

glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

cytochrome P450 2U1 isoform X1 [KO:K07422] [EC:1.14.14.80]

EH1; soluble epoxide hydrolase-like protein 1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]

eh2; soluble epoxide hydrolase-like protein 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]

Compound

Phosphatidylcholine

Arachidonate

Prostaglandin H2

Prostaglandin E2

Prostaglandin F2alpha

Prostaglandin D2

Leukotriene A4

Prostaglandin I2

Leukotriene B4

Leukotriene C4

Thromboxane A2

20-Hydroxyleukotriene E4

15-OxoETE

(5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate

(5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate

(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate

(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate

5(S)-HETE

8(R)-HPETE

(5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate

20-OH-Leukotriene B4

5(S)-HPETE

12-Keto-leukotriene B4

20-COOH-Leukotriene B4

Leukotriene D4

Leukotriene E4

Prostaglandin A2

Prostaglandin B2

Prostaglandin C2

Prostaglandin G2

Prostaglandin J2

Delta-12-Prostaglandin J2

11-epi-Prostaglandin F2alpha

15-Keto-prostaglandin F2alpha

6-Keto-prostaglandin F1alpha

6-Keto-prostaglandin E1

Thromboxane B2

11-Dehydro-thromboxane B2

12(S)-HPETE

15(S)-HPETE

Lipoxin A4

Lipoxin B4

Leukotriene F4

9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid

15-Deoxy-Delta12,14-PGJ2

5-OxoETE

20-HETE

19(S)-HETE

5,6-EET

8,9-EET

11,12-EET

14,15-EET

5,6-DHET

8,9-DHET

11,12-DHET

14,15-DHET

8(S)-HETE

12(S)-HETE

16(R)-HETE

9(S)-HETE

11(R)-HETE

15H-11,12-EETA

11,12,15-THETA

2,3-Dinor-8-iso prostaglandin F2alpha

2,3-Dinor-8-iso prostaglandin F1alpha

12-OxoETE

Hepoxilin A3

Trioxilin A3

Hepoxilin B3

Trioxilin B3

12(R)-HPETE

11H-14,15-EETA

11,14,15-THETA

5,6-Epoxytetraene

11(R)-HPETE

9(S)-HPETE

12(R)-HETE

8(S)-HPETE

8(R)-HETE

Reference

Authors

Spector AA, Fang X, Snyder GD, Weintraub NL.

Title

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.

Journal

Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3

Reference

Authors

Harman CA, Rieke CJ, Garavito RM, Smith WL.

Title

Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.

Journal

J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200

Reference

Authors

Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.

Title

The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.

Journal

Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727

Reference

Authors

Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.

Title

CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.

Journal

J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200

Reference

Authors

Sacerdoti D, Gatta A, McGiff JC.

Title

Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.

Journal

Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7

Reference

Authors

Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.

Title

Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.

Journal

Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026

Reference

Authors

Fleming I.

Title

Cytochrome p450 and vascular homeostasis.

Journal

Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268

Reference

Authors

Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.

Title

Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.

Journal

J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200

Reference

Authors

Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.

Title

CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.

Journal

Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279

Reference

Authors

Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.

Title

Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.

Journal

J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879

KO pathway

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