KEGG   PATHWAY: srn00230
Entry
srn00230                    Pathway                                
Name
Purine metabolism - Streptomyces rubrolavendulae
Class
Metabolism; Nucleotide metabolism
Pathway map
srn00230  Purine metabolism
srn00230

Module
srn_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:srn00230]
srn_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:srn00230]
srn_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:srn00230]
srn_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:srn00230]
srn_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:srn00230]
srn_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:srn00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces rubrolavendulae [GN:srn]
Gene
A4G23_00566  purB; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
A4G23_00713  guaB_1; Inosine-5'-monophosphate dehydrogenase [KO:K26110]
A4G23_00723  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
A4G23_00756  relA_1; Bifunctional (p)ppGpp synthase/hydrolase relA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
A4G23_00758  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
A4G23_00775  [KO:K19710] [EC:2.7.7.53]
A4G23_01270  yfiH; Laccase domain protein YfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
A4G23_01570  dgt; Deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
A4G23_01613  [KO:K21053] [EC:3.5.4.2]
A4G23_01690  ndkA; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
A4G23_01897  nagD; Ribonucleotide monophosphatase NagD [KO:K02566] [EC:3.1.3.5]
A4G23_01920  rdgB; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
A4G23_02061  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
A4G23_02062  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
A4G23_02116  gppA_1; Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
A4G23_02152  prs_1; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
A4G23_02539  yhcR; Endonuclease YhcR precursor [KO:K01081] [EC:3.1.3.5]
A4G23_02619  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
A4G23_02620  purF; Amidophosphoribosyltransferase precursor [KO:K00764] [EC:2.4.2.14]
A4G23_02623  purL; Phosphoribosylformylglycinamidine synthase 2 [KO:K23269]
A4G23_02624  purQ; Phosphoribosylformylglycinamidine synthase 1 [KO:K23265]
A4G23_02625  [KO:K23264]
A4G23_02633  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
A4G23_02636  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
A4G23_02966  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
A4G23_03100  hpt; Hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
A4G23_03147  gppA_2; Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
A4G23_03311  add2_1; Aminodeoxyfutalosine deaminase [KO:K01488] [EC:3.5.4.4]
A4G23_03389  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
A4G23_03443  guaB_2; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
A4G23_03444  [KO:K00088] [EC:1.1.1.205]
A4G23_03461  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
A4G23_03488  purN; Phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
A4G23_03489  purH; Bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
A4G23_03524  [KO:K16840] [EC:4.1.1.97]
A4G23_03575  [KO:K01488] [EC:3.5.4.4]
A4G23_03604  punA; Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
A4G23_03619  [KO:K01768] [EC:4.6.1.1]
A4G23_03841  nrdB; Ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
A4G23_03842  nrdZ; Ribonucleoside-diphosphate reductase NrdZ [KO:K00525] [EC:1.17.4.1]
A4G23_04085  ureA; Urease subunit alpha [KO:K14048] [EC:3.5.1.5]
A4G23_04086  ureC; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
A4G23_04305  relA_2; Bifunctional (p)ppGpp synthase/hydrolase relA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
A4G23_04312  nrdJ; Vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
A4G23_04691  cysNC; Bifunctional enzyme CysN/CysC [KO:K00956] [EC:2.7.7.4]
A4G23_04692  cysD; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
A4G23_04693  sat_cysC; putative bifunctional SAT/APS kinase [KO:K00860] [EC:2.7.1.25]
A4G23_04737  prs_2; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
A4G23_04757  cutS; Carbon monoxide dehydrogenase small chain [KO:K13483]
A4G23_04758  hcrB; 4-hydroxybenzoyl-CoA reductase subunit beta [KO:K11178] [EC:1.17.1.4]
A4G23_04759  xdhA; Xanthine dehydrogenase molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
A4G23_04934  [KO:K01488] [EC:3.5.4.4]
A4G23_05308  rihA; Pyrimidine-specific ribonucleoside hydrolase RihA [KO:K25589]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
srn00030  Pentose phosphate pathway
srn00220  Arginine biosynthesis
srn00250  Alanine, aspartate and glutamate metabolism
srn00260  Glycine, serine and threonine metabolism
srn00340  Histidine metabolism
srn00630  Glyoxylate and dicarboxylate metabolism
srn00730  Thiamine metabolism
srn00740  Riboflavin metabolism
srn00790  Folate biosynthesis
KO pathway
ko00230   

DBGET integrated database retrieval system