KEGG   PATHWAY: tci00260
Entry
tci00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Tatumella citrea
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
tci00260  Glycine, serine and threonine metabolism
tci00260

Module
tci_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:tci00260]
tci_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:tci00260]
tci_M00555  Betaine biosynthesis, choline => betaine [PATH:tci00260]
tci_M00621  Glycine cleavage system [PATH:tci00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Tatumella citrea [GN:tci]
Gene
A7K98_18185  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
A7K98_16480  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
A7K98_19820  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
A7K98_00250  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A7K98_16475  homoserine kinase [KO:K00872] [EC:2.7.1.39]
A7K98_16470  threonine synthase [KO:K01733] [EC:4.2.3.1]
A7K98_00785  hypothetical protein [KO:K01620] [EC:4.1.2.48]
A7K98_06690  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
A7K98_14915  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A7K98_16765  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
A7K98_09755  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
A7K98_09155  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
A7K98_09425  hypothetical protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
A7K98_14660  hypothetical protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
A7K98_00080  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
A7K98_00805  glycerate kinase [KO:K00865] [EC:2.7.1.165]
A7K98_11260  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
A7K98_06345  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
A7K98_16505  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
A7K98_04085  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A7K98_06815  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
A7K98_16595  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
A7K98_09915  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
A7K98_08200  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
A7K98_04165  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
A7K98_04155  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
A7K98_16075  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
A7K98_04160  glycine cleavage system protein H [KO:K02437]
A7K98_15720  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
A7K98_09785  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
A7K98_09790  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A7K98_14100  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A7K98_20675  hypothetical protein [KO:K00301] [EC:1.5.3.1]
A7K98_10600  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A7K98_19680  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A7K98_11405  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
A7K98_18655  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
A7K98_10275  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
A7K98_10270  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
A7K98_09635  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
A7K98_09640  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
tci00010  Glycolysis / Gluconeogenesis
tci00020  Citrate cycle (TCA cycle)
tci00230  Purine metabolism
tci00250  Alanine, aspartate and glutamate metabolism
tci00270  Cysteine and methionine metabolism
tci00290  Valine, leucine and isoleucine biosynthesis
tci00300  Lysine biosynthesis
tci00330  Arginine and proline metabolism
tci00460  Cyanoamino acid metabolism
tci00470  D-Amino acid metabolism
tci00564  Glycerophospholipid metabolism
tci00600  Sphingolipid metabolism
tci00620  Pyruvate metabolism
tci00630  Glyoxylate and dicarboxylate metabolism
tci00640  Propanoate metabolism
tci00680  Methane metabolism
tci00860  Porphyrin metabolism
tci00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system