KEGG   PATHWAY: uah00603
Entry
uah00603                    Pathway                                
Name
Glycosphingolipid biosynthesis - globo and isoglobo series - Ursus arctos (brown bear)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
uah00603  Glycosphingolipid biosynthesis - globo and isoglobo series
uah00603

Module
uah_M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer [PATH:uah00603]
Other DBs
GO: 0001576 1990387
Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113254148  B3GALNT1; UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1 [KO:K00719] [EC:2.4.1.79]
113266556  GBGT1; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X2 [KO:K00722] [EC:2.4.1.88]
113241688  A4GALT; lactosylceramide 4-alpha-galactosyltransferase isoform X1 [KO:K01988] [EC:2.4.1.228]
113244306  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
113257178  B3GALT5; beta-1,3-galactosyltransferase 5 [KO:K03877] [EC:2.4.1.-]
113240939  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
113255209  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
113241706  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
113243333  FUT1; galactoside alpha-(1,2)-fucosyltransferase 1 [KO:K00718] [EC:2.4.1.69]
113243338  galactoside alpha-(1,2)-fucosyltransferase 2 [KO:K00718] [EC:2.4.1.69]
113243340  galactoside 2-alpha-L-fucosyltransferase SEC1-like [KO:K00718] [EC:2.4.1.69]
113266557  LOW QUALITY PROTEIN: histo-blood group ABO system transferase 2 [KO:K00709] [EC:2.4.1.40 2.4.1.37]
113266558  histo-blood group ABO system transferase 1-like [KO:K00709] [EC:2.4.1.40 2.4.1.37]
113252698  ST3GAL1; CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1 isoform X1 [KO:K00780] [EC:2.4.3.2 2.4.3.4]
113252473  ST3GAL2; CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.3.2 2.4.3.4]
113257801  ST8SIA1; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase [KO:K03371] [EC:2.4.3.8]
113264665  FUT9; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 [KO:K03663] [EC:2.4.1.152]
Compound
G00092  Lactosylceramide
G00093  Globotriaosylceramide
G00094  Globoside
G00095  Forssman antigen
G00096  IV3GalNAcb-Gb4Cer
G00097  Galactosylgloboside
G00098  Monosialylgalactosylgloboside
G00099  Globo-H
G00100  V3(NeuAc)2-Gb5Cer
G00101   
G00102   
G00103   
G00104   
G00105  GalGb3Cer
G00106   
G00107   
G00181  Disialosylglobopentaosylceramide
G00392  iGb4-Cer
G00403  iGb3-Cer
G00474  Globo-A
G02977   
G11492  IV4-alpha-Gal-Gb4Cer
G13080  NORint
G13081  NOR2 antigen
G13341  Globo-B
Reference
PMID:12716912
  Authors
Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T.
  Title
Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
  Journal
J Biol Chem 278:26474-9 (2003)
DOI:10.1074/jbc.M213223200
Reference
PMID:10837462
  Authors
Zhou D, Henion TR, Jungalwala FB, Berger EG, Hennet T.
  Title
The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase.
  Journal
J Biol Chem 275:22631-4 (2000)
DOI:10.1074/jbc.C000263200
Reference
PMID:10748143
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  Journal
J Biol Chem 275:15152-6 (2000)
DOI:10.1074/jbc.M909620199
Reference
PMID:10854428
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU.
  Title
Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipidsynthesis, predicts a family of alpha 1, 4-glycosyltransferases conservedin plants, insects, and mammals.
  Journal
J Biol Chem 275:25315-21 (2000)
DOI:10.1074/jbc.M002630200
Reference
PMID:10854427
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU
  Title
Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.
  Journal
J Biol Chem 275:25308-14 (2000)
DOI:10.1074/jbc.M002629200
Related
pathway
uah00600  Sphingolipid metabolism
KO pathway
ko00603   
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