KEGG   PATHWAY: ko00603
Entry
ko00603                     Pathway                                
Name
Glycosphingolipid biosynthesis - globo and isoglobo series
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
ko00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ko00603

Module
M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer [PATH:ko00603]
Other DBs
GO: 0001576 1990387
Orthology
K00709  ABO; histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]
K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]
K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]
K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase [EC:2.4.1.88]
K00780  ST3GAL1; beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.3.2 2.4.3.4]
K01189  GLA; alpha-galactosidase [EC:3.2.1.22]
K01204  NAGA; alpha-N-acetylgalactosaminidase [EC:3.2.1.49]
K01988  A4GALT; lactosylceramide 4-alpha-galactosyltransferase [EC:2.4.1.228]
K03368  ST3GAL2; beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B) [EC:2.4.3.2 2.4.3.4]
K03371  ST8SIA1; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) [EC:2.4.3.8]
K03663  FUT9; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase [EC:2.4.1.152]
K03877  B3GALT5; beta-1,3-galactosyltransferase 5 [EC:2.4.1.-]
K07406  melA; alpha-galactosidase [EC:3.2.1.22]
K07407  E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22]
K12373  HEXA_B; hexosaminidase [EC:3.2.1.52]
K20736  A3GALT2; alpha-1,3-galactosyltransferase 2 [EC:2.4.1.87]
Compound
G00092  Lactosylceramide
G00093  Globotriaosylceramide
G00094  Globoside
G00095  Forssman antigen
G00096  IV3GalNAcb-Gb4Cer
G00097  Galactosylgloboside
G00098  Monosialylgalactosylgloboside
G00099  Globo-H
G00100  V3(NeuAc)2-Gb5Cer
G00101  
G00102  
G00103  
G00104  
G00105  GalGb3Cer
G00106  
G00107  
G00181  Disialosylglobopentaosylceramide
G00392  iGb4-Cer
G00403  iGb3-Cer
G00474  Globo-A
G02977  
G11492  IV4-alpha-Gal-Gb4Cer
G13080  NORint
G13081  NOR2 antigen
G13341  Globo-B
Reference
PMID:12716912
  Authors
Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T.
  Title
Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
  Journal
J Biol Chem 278:26474-9 (2003)
DOI:10.1074/jbc.M213223200
Reference
PMID:10837462
  Authors
Zhou D, Henion TR, Jungalwala FB, Berger EG, Hennet T.
  Title
The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase.
  Journal
J Biol Chem 275:22631-4 (2000)
DOI:10.1074/jbc.C000263200
Reference
PMID:10748143
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  Journal
J Biol Chem 275:15152-6 (2000)
DOI:10.1074/jbc.M909620199
Reference
PMID:10854428
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU.
  Title
Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipidsynthesis, predicts a family of alpha 1, 4-glycosyltransferases conservedin plants, insects, and mammals.
  Journal
J Biol Chem 275:25315-21 (2000)
DOI:10.1074/jbc.M002630200
Reference
PMID:10854427
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU
  Title
Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.
  Journal
J Biol Chem 275:25308-14 (2000)
DOI:10.1074/jbc.M002629200
Related
pathway
ko00600  Sphingolipid metabolism

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