KEGG   PATHWAY: vpk00260
Entry
vpk00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Vibrio parahaemolyticus O1:K33 CDC_K4557
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vpk00260  Glycine, serine and threonine metabolism
vpk00260

Module
vpk_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vpk00260]
vpk_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vpk00260]
vpk_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:vpk00260]
vpk_M00555  Betaine biosynthesis, choline => betaine [PATH:vpk00260]
vpk_M00621  Glycine cleavage system [PATH:vpk00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Vibrio parahaemolyticus O1:K33 CDC_K4557 [GN:vpk]
Gene
M636_08225  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M636_09170  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M636_13475  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M636_19355  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
M636_23645  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
M636_10960  semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M636_11225  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M636_19350  homoserine kinase [KO:K00872] [EC:2.7.1.39]
M636_12800  hypothetical protein [KO:K02204] [EC:2.7.1.39]
M636_19345  threonine synthase [KO:K01733] [EC:4.2.3.1]
M636_04455  threonine aldolase [KO:K01620] [EC:4.1.2.48]
M636_18265  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M636_03465  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M636_08235  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
M636_08415  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
M636_08065  glycerate kinase [KO:K00865] [EC:2.7.1.165]
M636_23285  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
M636_08965  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M636_15570  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
M636_09795  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
M636_06385  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
M636_06380  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
M636_03455  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
M636_03475  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
M636_09370  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
M636_03460  glycine cleavage system protein H [KO:K02437]
M636_22745  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
M636_04950  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
M636_04955  4-trimethylaminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
M636_12425  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
M636_00595  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
M636_21925  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
M636_15565  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
M636_23190  alanine racemase [KO:K25317] [EC:5.1.1.10]
M636_12010  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
M636_12015  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
M636_02145  tryptophan synthase subunit alpha [KO:K01696] [EC:4.2.1.20]
M636_13465  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
M636_12120  aminotransferase class III [KO:K00836] [EC:2.6.1.76]
M636_13460  2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
M636_13470  ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vpk00010  Glycolysis / Gluconeogenesis
vpk00020  Citrate cycle (TCA cycle)
vpk00230  Purine metabolism
vpk00250  Alanine, aspartate and glutamate metabolism
vpk00270  Cysteine and methionine metabolism
vpk00290  Valine, leucine and isoleucine biosynthesis
vpk00300  Lysine biosynthesis
vpk00330  Arginine and proline metabolism
vpk00460  Cyanoamino acid metabolism
vpk00470  D-Amino acid metabolism
vpk00564  Glycerophospholipid metabolism
vpk00600  Sphingolipid metabolism
vpk00620  Pyruvate metabolism
vpk00630  Glyoxylate and dicarboxylate metabolism
vpk00640  Propanoate metabolism
vpk00680  Methane metabolism
vpk00860  Porphyrin metabolism
vpk00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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