KEGG   PATHWAY: zca03013
Entry
zca03013                    Pathway                                
Name
Nucleocytoplasmic transport - Zalophus californianus (California sea lion)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
zca03013  Nucleocytoplasmic transport
zca03013

Other DBs
GO: 0050658
Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113907865  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
113907891  CASC3; protein CASC3 [KO:K14323]
113908133  ALYREF; THO complex subunit 4 [KO:K12881]
113908183  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
113908864  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
113909005  PNN; pinin [KO:K13114]
113909856  SNUPN; snurportin-1 [KO:K13151]
113909898  NDC1; nucleoporin NDC1 [KO:K14315]
113910109  IPO13; importin-13 isoform X1 [KO:K25202]
113910420  IPO4; importin-4 isoform X1 [KO:K20221]
113911272  TNPO3; transportin-3 isoform X1 [KO:K15436]
113911309  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
113911662  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
113911698  [KO:K12160]
113911951  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
113912302  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
113912438  [KO:K03231]
113912701  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
113913050  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
113913919  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
113913944  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
113914061  [KO:K12160]
113914100  IPO7; importin-7 [KO:K20223]
113915001  [KO:K14303]
113915075  [KO:K12160]
113915820  [KO:K12160]
113916251  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
113916470  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
113916723  KPNA1; importin subunit alpha-5 [KO:K23940]
113916739  MAGOH; protein mago nashi homolog [KO:K12877]
113916841  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
113916963  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
113917336  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
113917463  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
113917927  TNPO2; transportin-2 isoform X1 [KO:K18727]
113917936  [KO:K12160]
113918237  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
113918341  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
113918432  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
113919356  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
113919613  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
113919698  IPO5; importin-5 [KO:K20222]
113919763  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
113919950  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
113920008  XPO4; exportin-4 isoform X1 [KO:K25203]
113920196  KPNA3; importin subunit alpha-4 [KO:K23583]
113920729  [KO:K03231]
113920959  SAP18; histone deacetylase complex subunit SAP18 isoform X1 [KO:K14324]
113921481  XPOT; exportin-T [KO:K14288]
113921875  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
113921921  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
113922073  PYM1; partner of Y14 and mago [KO:K14294]
113922213  [KO:K14319]
113922316  [KO:K07936]
113922475  IPO8; importin-8 [KO:K18755]
113922751  NUP37; nucleoporin Nup37 isoform X1 [KO:K14302]
113922826  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
113923048  AAAS; aladin isoform X1 [KO:K14320]
113923168  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
113923484  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
113923668  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
113924175  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
113924346  XPO7; exportin-7 isoform X1 [KO:K18460]
113924409  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
113924685  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
113924720  [KO:K18752]
113924738  [KO:K12160]
113924832  [KO:K13171]
113925109  [KO:K12160]
113925634  [KO:K07936]
113926317  XPO5; exportin-5 isoform X1 [KO:K14289]
113926372  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
113926734  [KO:K12160]
113926814  POM121L2; POM121-like protein 2 [KO:K14316]
113927026  [KO:K14298]
113927095  [KO:K03231]
113927576  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
113927594  [KO:K03231]
113927646  NUP43; nucleoporin Nup43 [KO:K14305]
113927732  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
113927855  [KO:K13174]
113927881  [KO:K12160]
113927902  [KO:K03231]
113928958  TNPO1; transportin-1 isoform X1 [KO:K18752]
113929015  THOC3; THO complex subunit 3 [KO:K12880]
113929108  IPO11; importin-11 isoform X1 [KO:K25201]
113929231  [KO:K12883]
113929239  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
113929499  [KO:K14306]
113929510  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
113929640  [KO:K12160]
113929867  PHAX; phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
113930239  [KO:K14284]
113930324  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
113930470  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
113930705  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
113930762  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
113930828  [KO:K18460]
113930951  [KO:K14284]
113930978  [KO:K14284]
113931495  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
113931515  [KO:K15043]
113931533  [KO:K12160]
113931866  XPO6; exportin-6 isoform X1 [KO:K25204]
113931937  AHCTF1; protein ELYS isoform X1 [KO:K25129]
113931962  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
113932282  IPO9; importin-9 [KO:K20224]
113932738  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
113932921  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
113932946  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
113933233  THOC6; THO complex subunit 6 homolog [KO:K13175]
113933386  KPNA7; importin subunit alpha-8 [KO:K15043]
113933442  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
113934011  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
113934269  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
113934414  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
113934735  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
113934872  [KO:K13176]
113934878  [KO:K12160]
113935491  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
113935946  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
113935956  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
113936064  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
113937064  [KO:K12877]
113937360  CSE1L; exportin-2 [KO:K18423]
113937577  NXT1; NTF2-related export protein 1 [KO:K14285]
113937668  XPO1; exportin-1 [KO:K14290]
113938205  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
113938286  RAE1; mRNA export factor isoform X1 [KO:K14298]
113938313  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
113938471  [KO:K03231]
113939000  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
113939075  [KO:K15043]
113939391  KPNB1; importin subunit beta-1 isoform X1 [KO:K14293]
113939525  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
113939882  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
118356262  [KO:K03231]
118356537  [KO:K14284]
118356820  [KO:K03231]
118356867  [KO:K03231]
118356941  [KO:K03231]
118357005  [KO:K03231]
118357088  [KO:K15043]
118357108  [KO:K15043]
118357158  [KO:K03231]
118357195  [KO:K03231]
118357197  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
118357224  [KO:K03231]
118357257  [KO:K15043]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
zca03015  mRNA surveillance pathway
KO pathway
ko03013   

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