KEGG image  Pharmacogenomic Biomarkers

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Somatic variations in targeted cancer therapies

Drug KEGG
DRUG
ATC Product Target KEGG
VARIANT
Biomarker KEGG
NETWORK
Rituximab D02994 L01XC02 Rituxan CD20 CD20 positive
Trastuzumab D03257 L01XC03 Herceptin HER2 2064v1
2064v3
HER2 overexpression/amplification nt06270
nt06261
Gemtuzumab ozogamicin D03259 L01XC05 Mylotarg CD33 CD33 positive
Cetuximab D03455 L01XC06 Erbitux EGFR EGFR expression, KRAS wild type
Panitumumab D05350 L01XC08 Vectibix EGFR EGFR expression, KRAS wild type
Ofatumumab D09314 L01XC10 Arzerra CD20 CD20 positive
Ipilimumab D04603 L01XC11 Yervoy CTLA4 Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
Brentuximab vedotin D09587 L01XC12 Adcetris CD30 CD30 positive
Pertuzumab D05446 L01XC13 Perjeta HER2 2064v1
2064v3
HER2 overexpression/amplification nt06270
Trastuzumab emtansine D09980 L01XC14 Kadcyla HER2 2064v1
2064v3
HER2 overexpression/amplification nt06270
Obinutuzumab D09321 L01XC15 Gazyva CD20 CD20 positive
Dinutuximab D10559 L01XC16 Unituxin GD2 MYCN amplification
Nivolumab D10316 L01XC17 Opdivo PD1 PDL1 positive
BRAF V600
Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
Pembrolizumab D10574 L01XC18 Keytruda PD1 PDL1 positive
Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
Blinatumomab D09325 L01XC19 Blincyto CD19 Philadelphia chromosome (BCR-ABL fusion gene) negative
Mogamulizumab D09761 L01XC25 Poteligeo CCR4 CCR4 positive
Inotuzumab ozogamicin D08933 L01XC26 Besponsa CD22 CD22 positive
Durvalumab D10808 L01XC28 Imfinzi PDL1 PDL1 positive
Avelumab D10817 L01XC31 Bavencio PDL1 PDL1 positive
Atezolizumab D10773 L01XC32 Tecentriq PDL1 PDL1 positive
Cemiplimab D11108 L01XC33 Libtayo PD1 PDL1 positive
Imatinib D01441 L01XE01 Gleevec BCR-ABL
FIP1L1-PDGFRA
KIT
PDGFR
25v1 Philadelphia chromosome (BCR-ABL fusion gene)
FIP1L1-PDGFRA fusion gene
KIT mutation D816V negative
PDGFR rearrangement
nt06276
Gefitinib D01977 L01XE02 Iressa EGFR 1956v2 EGFR exon 19 deletion or exon 21 L858R mutation nt06266
Erlotinib D04023 L01XE03 Tarceva EGFR 1956v2 EGFR exon 19 deletion or exon 21 L858R mutation nt06266
Dasatinib D06414 L01XE06 Sprycel BCR-ABL 25v2 Philadelphia chromosome, BCR-ABL T315I mutation nt06276
Lapatinib D04024 L01XE07 Tykerb EGFR
HER2
2064v1 HER2 overexpression
ESR1, PGR positive
HLA-DQA1*0201 or HLA-DRB1*0701 allele carrier
nt06270
Nilotinib D06413 L01XE08 Tasigna BCR-ABL 25v2
54658v1
Philadelphia chromosome (BCR-ABL fusion gene)
UGT1A1*28 allele homozygotes
nt06276
Everolimus D02714 L01XE10
L04AA18
Afinitor
Zortress
MTOR ESR1 positive
HER2 negative
Afatinib D09733 L01XE13 Giotrif EGFR 1956v2 EGFR exon 19 deletion or exon 21 L858R mutation nt06266
Bosutinib D09728 L01XE14 Bosulif BCR-ABL 25v2 Philadelphia chromosome (BCR-ABL fusion gene) nt06276
Vemurafenib D09996 L01XE15 Zelboraf BRAF 673v1 BRAF V600E mutation
NRAS mutation
nt06268
Crizotinib D09731 L01XE16 Xalkori EML4-ALK
ROS1
238v1
6098v1
EML4-ALK fusion gene
ROS1 fusion gene
nt06266
Dabrafenib D10104 L01XE23 Tafinlar BRAF 673v1 BRAF V600E mutation
G6PD deficiency
nt06268
Ponatinib D09951 L01XE24 Iclusig BCR-ABL 25v2 Philadelphia chromosome, BCR-ABL T315I mutation nt06276
Trametinib D10176 L01XE25 Mekinist MEK 673v1 BRAF V600E/K mutation nt06268
Ibrutinib D10223 L01XE27 Imbruvica BTK Chromosome 17p deletion
Chromosome 11q deletion
Ceritinib D10551 L01XE28 Zykadia EML4-ALK 238v2 ALK gene rearrangement nt06266
Palbociclib D10372 L01XE33 Ibrance CDK4/6 ESR1 positive
HER2 negative
Osimertinib D10766 L01XE35 Tagrisso EGFR 1956v3 EGFR T790M mutation nt06266
Alectinib D10450 L01XE36 Alecensa EML4-ALK 238v2 ALK gene rearrangement nt06266
Cobimetinib D10615 L01XE38 Cotellic MEK 673v1 BRAF V600E/K mutation nt06268
Midostaurin D05029 L01XE39 Rydapt FLT3 (CD135) 2322v1
2322v2
FLT3 mutation
Binimetinib D10604 L01XE41 Mektovi MEK 673v1 BRAF V600E/K mutation nt06268
Ribociclib D10979 L01XE42 Kisqali CDK4/6 ESR1 positive
HER2 negative
Brigatinib D10866 L01XE43 Alunbrig EML4-ALK 238v2 ALK gene rearrangement nt06266
Lorlatinib D11012 L01XE44 Lorbrena EML4-ALK 238v2 ALK gene rearrangement nt06266
Neratinib D10898 L01XE45 Nerlynx EGFR
HER2
HER4
2064v1
2064v3
HER2 overexpression/amplification nt06270
Encorafenib D11053 L01XE46 Braftovi BRAF 673v1 BRAF V600E/K mutation nt06268
Dacomitinib D09883 L01XE47 Vizimpro EGFR 1956v2 EGFR exon 19 deletion or exon 21 L858R mutation nt06266
Abemaciclib D10688 L01XE50 Verzenio CDK4/6 ESR1 positive
HER2 negative
Larotrectinib D11138 L01XE53 Vitrakvi TRKA TRK positive
Gilteritinib D10800 L01XE54 Xospata FLT3 (CD135) 2322v1
2322v2
FLT3 mutation
Omacetaxine D08956 L01XX40 Synribo CCND1 Philadelphia chromosome (BCR-ABL fusion gene) negative
Olaparib D09730 L01XX46 Lynparza PARP1 BRCA1,2 mutation
HER2 negative
Venetoclax D10679 L01XX52 Venclexta BCL2 Chromosome 17p deletion
Niraparib D10140 L01XX54 Zejula PARP1 BRCA1,2 mutation or wild type
Rucaparib D10079 L01XX55 Rubraca PARP1 BRCA1,2 mutation
Enasidenib D11044 L01XX59 Idhifa IDH2 3418v1 IDH2 mutation
Talazoparib D10733 L01XX60 Talzenna PARP1/2 BRCA1,2 mutation
HER2 negative
Ivosidenib D11090 L01XX62 Tibsovo IDH1 3417v1 IDH1 mutation
Tamoxifen D00966 L02BA01 Nolvadex NR3A (ESR)
2153v1
2147v1
ESR1, PGR positive
Factor V Leiden negative
Prothrombin G20210A negative
Fulvestrant D01161 L02BA03 Faslodex NR3A (ESR) ESR1, PGR positive
HER2 negative
Anastrozole D00960 L02BG03 Arimidex CYP19A1 (ARO) ESR1, PGR positive
Letrozole D00964 L02BG04 Femara CYP19A1 (ARO) ESR1, PGR positive
Exemestane D00963 L02BG06 Aromasin CYP19A1 (ARO) ESR1, PGR positive
Ibritumomab tiuxetan D04489 V10XX02 Zevalin CD20 CD20 positive

Germline mutations in genetic disorder treatments

Drug KEGG
DRUG
ATC Product KEGG
VARIANT
Biomarker KEGG
NETWORK
Imiglucerase D03020 A16AB02 Cerezyme 2629v1 GBA deficiency (enzyme replacement) nt06014
Agalsidase alpha D02784 A16AB03 2717v1 GLA deficiency (enzyme replacement) nt06014
Agalsidase beta D03228 A16AB04 Fabrazyme 2717v1 GLA deficiency (enzyme replacement) nt06014
Carglumic acid D07130 A16AA05 Carbaglu 162417v1 NAGS deficiency (CPS1 activator) nt06010
Laronidase D04670 A16AB05 Aldurazyme 3425v1 IDUA deficiency (enzyme replacement) nt06012
Sacrosidase D05782 A16AB06 Sucraid 6476v1 SI deficiency (enzyme replacement)
Alglucosidase alfa D03207 A16AB07 Lumizyme 2548v1 GAA deficiency (enzyme replacement) nt06017
Galsulfase D06565 A16AB08 Naglazyme 411v1 ARSB deficiency (enzyme replacement) nt06012
Idursulfase D04499 A16AB09 Elaprase 3423v1 IDS deficiency (enzyme replacement) nt06012
Velaglucerase alfa D09029 A16AB10 Vpriv 2629v1 GBA deficiency (enzyme replacement) nt06014
Taliglucerase alfa D09675 A16AB11 Elelyso 2629v1 GBA deficiency (enzyme replacement) nt06014
Elosulfase D10333 A16AB12 Vimizim 2588v1 GALNS deficiency (enzyme replacement) nt06012
Asfotase alfa D10595 A16AB13 Strensiq 249v1 ALPL deficiency (enzyme replacement)
Sebelipase alfa D10377 A16AB14 Kanuma 3988v1 LIPA deficiency (enzyme replacement)
Cerliponase alfa D10813 A16AB17 Brineura 1200v1 TPP1 deficiency (enzyme replacement)
Vestronidase alfa D11004 A16AB18 MepseVII 2990v1 GUSB deficiency (enzyme replacement)
Sodium phenylbutyrate D05868 A16AX03 Buphenyl 445v1
1373v1
5009v1
ASS1, CPS1, OTC deficiency
Nitisinone D05177 A16AX04 Orfadin 2184v1 FAH deficiency (HPD inhibitor) nt06016
Miglustat D05032 A16AX06 Zavesca 2629v1 GBA deficiency (UGCG inhibitor) nt06014
Sapropterin D01798 A16AX07 Kuvan 5860v1 QDPR deficiency (cofactor replacement) nt06016
Eliglustat D09894 A16AX10 Cerdelga 2629v1 GBA deficiency (UGCG inhibitor)
CYP2D6 polymorphism
nt06014
Migalastat D05031 A16AX14 Galafold 2717v2 GLA variant (migalastat amenable) nt06014
Eteplirsen D09900 M09AX06 Exondys 51 DMD mutation (exon 51 skipping)
Ivacaftor D09916 R07AX02 Kalydeco CFTR mutation (G551D, etc.)
Lumacaftor and ivacaftor D10685 R07AX30 Orkambi CFTR mutation (F508del)
Tezacaftor and ivacaftor D11042 R07AX31 Cymdeko CFTR mutation (F508del)

Pathogen genome variants in infectious disease treatments

Drug KEGG
DRUG
ATC Product Target Biomarker
Maraviroc D06670 J05AX09 Selzentry CCR5 CCR5-tropic HIV-1 (R5 variant)

Polymorphisms and mutations affecting drug response

Drug KEGG
DRUG
ATC KEGG
VARIANT
Biomarker
Omeprazole D00455
D05259
A02BC01 1557v1 CYP2C19 polymorphism
Pantoprazole D02593 A02BC02 1557v1 CYP2C19 polymorphism
Lansoprazole D00355 A02BC03 1557v1 CYP2C19 polymorphism
Rabeprazole D00724 A02BC04 1557v1 CYP2C19 polymorphism
Esomeprazole D01984
D04056
D10120
A02BC05 1557v1 CYP2C19 polymorphism
Dexlansoprazole D08903 A02BC06 1557v1 CYP2C19 polymorphism
Metoclopramide D05008 A03FA01
2539v1
CYB5R deficiency
G6PD deficiency
Palonosetron D05343 A04AA05 1565v1 CYP2D6 polymorphism
Dronabinol D00306 A04AD10 1559v1 CYP2C9 polymorphism
Sulfasalazine D00448 A07EC01 2539v1 G6PD deficiency
Glibenclamide (Glyburide) D00336 A10BB01 2539v1 G6PD deficiency
Chlorpropamide D00271 A10BB02 2539v1 G6PD deficiency
Glipizide D00335 A10BB07 2539v1 G6PD deficiency
Glimepiride D00593 A10BB12 2539v1 G6PD deficiency
Warfarin D00564 B01AA03 79001v1
1559v1

 
VKORC1 rs9923231
CYP2C9 polymorphism
PROC deficiency
PROS deficiency
Clopidogrel D00769 B01AC04 1557v1 CYP2C19 polymorphism
Prasugrel D05597 B01AC22 1557v1
1559v1
1577v1
1555v1
CYP2C19 polymorphism
CYP2C9 polymorphism
CYP3A5 polymorphism
CYP2B6 polymorphism
Ticagrelor D09017 B01AC24 1557v1 CYP2C19 polymorphism
Eltrombopag D03978 B02BX05 2153v1
 
Factor V Leiden
ATIII deficiency
Lusutrombopag D10476 B02BX07 2153v1
2147v1


 
Factor V Leiden
Prothrombin 20210A
ATIII deficiency
PROC deficiency
PROS deficiency
Avatrombopag D10307 B02BX08 2153v1
2147v1


 
Factor V Leiden
Prothrombin 20210A
ATIII deficiency
PROC deficiency
PROS deficiency
Quinidine D00642
D02272
C01BA01 1565v1 CYP2D6 polymorphism
Procainamide D08421
D00477
C01BA02 9v1
10v1
NAT polymorphism
Propafenone D00640 C01BC03 1565v1 CYP2D6 polymorphism
Isosorbide dinitrate D00516 C01DA08 CYB5R deficiency
Isosorbide mononitrate D00630 C01DA14 CYB5R deficiency
Hydralazine and isosorbide D10209 9v1
10v1
NAT polymorphism
Propranolol D00483 C07AA05 1565v1 CYP2D6 polymorphism
Metoprolol D00601
D00635
C07AB02 1565v1 CYP2D6 polymorphism
Carvedilol D00255
D03415
C07AG02 1565v1 CYP2D6 polymorphism
Rosuvastatin D01915 C10AA07 SLCO1B1 polymorphism
Mafenide D01166 D06BA03 2539v1 G6PD deficiency
Dapsone D00592 D10AX05
J04BA02
2539v1 G6PD deficiency
Flibanserin D02577 G02CX02 1559v1
1557v1
1565v1
CYP2C9 polymorphism
CYP2C19 polymorphism
CYP2D6 polymorphism
Drospirenone and ethinylestradiol D09741 G03AA12 1557v1 CYP2C19 polymorphism
Tolterodine D01148 G04BD07 1565v1 CYP2D6 polymorphism
Darifenacin D01699 G04BD10 1565v1 CYP2D6 polymorphism
Fesoterodine D08923 G04BD11 1565v1 CYP2D6 polymorphism
Parathyroid hormone D05364 H05AA03 CASR positive
Sulfamethoxazole and trimethoprim D00285 J01EE01 2539v1 G6PD deficiency
Nalidixic acid D00183 J01MB02 2539v1 G6PD deficiency
Nitrofurantoin D00439 J01XE01 2539v1 G6PD deficiency
Voriconazole D00578 J02AC03 1557v1 CYP2C19 polymorphism
Rifampin, isoniazid, and pyrazinamide D10210 9v1
10v1
NAT polymorphism
Efavirenz D00896 J05AG03 1555v1 CYP2B6
Abacavir D00891 J05AF06 HLA-B*5701
Daclatasvir D10105 J05AP07 282617v1 IL28B rs12979860
Elbasvir and grazoprevir D10778 J05AP54 IL28B allele carrier
Dolutegravir D10113 J05AX12 54658v1 UGT1A1 polymorphism
Sofosbuvir D10366 J05AX15 282617v1 IL28B rs12979860
Dasabuvir, ombitasvir,
paritaprevir and ritonavir
D10582 J05AX66 282617v1 IL28B rs12979860
Mercaptopurine D00161 L01BB02 7172v1 TPMT polymorphism
Thioguanine D06109 L01BB03 7172v1 TPMT polymorphism
Fluorouracil D00584 L01BC02 DPYD deficiency
Capecitabine D01223 L01BC06 DPYD deficiency
Cisplatin D00275 L01XA01 7172v1 TPMT polymorphism
Lapatinib D04024 L01XE07 HLA-DQA1*0201
HLA-DRB1*0701
Nilotinib D06413 L01XE08 54658v1 UGT1A1 polymorphism
Pazopanib D05380 L01XE11 54658v1 UGT1A1 polymorphism
Irinotecan D01061 L01XX19 54658v1 UGT1A1 polymorphism
Belinostat D08870 L01XX49 54658v1 UGT1A1 polymorphism
Peginterferon alfa-2b D02748 L03AB10 IL28B rs12979860
Mycophenolic acid D00752
D05095
D05096
L04AA06 HPRT deficiency
Azathioprine D00238 L04AX01 7172v1 TPMT polymorphism
Lenalidomide D04687 L04AX04 Chromosome 5q deletion
Piroxicam D00127 M01AC01 1559v1 CYP2C9 polymorphism
Celecoxib D00567 L01XX33
M01AH01
1559v1 CYP2C9 polymorphism
Flurbiprofen D00330
D02290
M01AE09
M02AA19
R02AX01
S01BC04
1559v1 CYP2C9 polymorphism
Succinylcholine D00766 M03AB01 BCHE deficiency
Carisoprodol D00768 M03BA02 1557v1 CYP2C19 polymorphism
Lesinurad D09921 M04AB05 1559v1 CYP2C9 polymorphism
Pegloticase D09316 M04AX02 G6PD deficiency
Sevoflurane D00547 N01AB08 RYR1 positive
Prilocaine and lidocaine D02740 N01BB52
N01BB54

2539v1
CYB5R deficiency
G6PD deficiency
Tramadol D01355 N02AX02 1565v1 CYP2D6 polymorphism
Tramadol and acetaminophen D09999 N02AX52 1565v1 CYP2D6 polymorphism
Phenytoin D00512
D02103
N03AB02 HLA-B*1502
Carbamazepine D00252 N03AF01 HLA-B*1502
HLA-A*3101
Oxcarbazepine D00533 N03AF02 HLA-B*1502
Valproic acid D00399
D00304
D00710
N03AG01 1373v1
5009v1
162417v1
445v1
435v1
383v1
POLG deficiency
CPS1,OTC,NAGS / ASS1,ASL / ARG deficiency
(Urea cycle disorders)
Lacosamide D07299 N03AX18 1557v1 CYP2C19 polymorphism
Brivaracetam D08879 N03AX23 1557v1 CYP2C19 polymorphism
Perphenazine D00503 N05AB03 1565v1 CYP2D6 polymorphism
Thioridazine D00798 N05AC02 1565v1 CYP2D6 polymorphism
Pimozide D00560 N05AG02 1565v1 CYP2D6 polymorphism
Clozapine D00283 N05AH02 1565v1 CYP2D6 polymorphism
Risperidone D00426 N05AX08 1565v1 CYP2D6 polymorphism
Aripiprazole D01164
D10364
N05AX12 1565v1 CYP2D6 polymorphism
Brexpiprazole D10309 N05AX13 1565v1 CYP2D6 polymorphism
Iloperidone D02666 N05AX14 1565v1 CYP2D6 polymorphism
Diazepam D00293 N05BA01 1557v1 CYP2C19 polymorphism
Clobazam D01253 N05BA09 1557v1 CYP2C19 polymorphism
Desipramine D00812 N06AA01 1565v1 CYP2D6 polymorphism
Imipramine D00815 N06AA02 1565v1 CYP2D6 polymorphism
Clomipramine D00811 N06AA04 1565v1 CYP2D6 polymorphism
Amitriptyline D00809 N06AA09 1565v1 CYP2D6 polymorphism
Trimipramine D02408 N06AA06 1565v1 CYP2D6 polymorphism
Nortriptyline D00816 N06AA10 1565v1 CYP2D6 polymorphism
Protriptyline D00484 N06AA11 1565v1 CYP2D6 polymorphism
Doxepin D00814 N06AA12 1557v1
1565v1
CYP2C19 polymorphism
CYP2D6 polymorphism
Fluoxetine D00823 N06AB03 1565v1 CYP2D6 polymorphism
Citalopram D00822 N06AB04 1557v1
1565v1
CYP2C19 polymorphism
CYP2D6 polymorphism
Paroxetine D02260
D05374
D05375
N06AB05 1565v1 CYP2D6 polymorphism
Fluvoxamine D00824 N06AB08 1565v1 CYP2D6 polymorphism
Escitalopram D02567 N06AB10 1557v1
1565v1
CYP2C19 polymorphism
CYP2D6 polymorphism
Nefazodone D00819 N06AX06 1565v1 CYP2D6 polymorphism
Venlafaxine D00821 N06AX16 1565v1 CYP2D6 polymorphism
Duloxetine D01179 N06AX21 1565v1 CYP2D6 polymorphism
Vortioxetine D10185 N06AX26 1565v1 CYP2D6 polymorphism
Chlordiazepoxide and amitriptyline D10207 N06CA01 1565v1 CYP2D6 polymorphism
Modafinil D01832 N06BA07 1565v1 CYP2D6 polymorphism
Atomoxetine D02574 N06BA09 1565v1 CYP2D6 polymorphism
Galantamine D02173 N06DA04 1565v1 CYP2D6 polymorphism
Cevimeline D00661 N07AX03 1565v1 CYP2D6 polymorphism
Lofexidine D04765 N07BC04 1565v1 CYP2D6 polymorphism
Tetrabenazine D08575 N07XX06 1565v1 CYP2D6 polymorphism
Dextromethorphan and quinidine D10208 N07XX59 1565v1 CYP2D6 polymorphism
Deutetrabenazine D10701 1565v1 CYP2D6 polymorphism
Valbenazine D10999 1565v1 CYP2D6 polymorphism
Chloroquine D02125 P01BA01 2539v1 G6PD deficiency
Primaquine D02126 P01BA03 2539v1 G6PD deficiency
Quinine sulfate D02262 P01BC01 2539v1
1565v1
G6PD deficiency
CYP2D6 polymorphism
Indacaterol D09319 R03AC18 54658v1 UGT1A1 polymorphism
Arformoterol D02981 54658v1
1565v1
UGT1A1 polymorphism
CYP2D6 polymorphism
Codeine D03580 R05DA04 1565v1 CYP2D6 polymorphism
Sodium nitrite D05865 V03AB08 2539v1 G6PD deficiency
Methylene blue D02312 V03AB17 2539v1 G6PD deficiency
Succimer D00572 2539v1 G6PD deficiency
Rasburicase D05704 V03AF07 2539v1 G6PD deficiency
CYB5R deficiency

See also: Pharmacogenomic biomarkers in drug labels

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Last updated: May 19, 2019