Entry
Name
Alzheimer disease - Cervus canadensis (wapiti)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
BRITE hierarchy
Pathway map
Ortholog table
Organism
Cervus canadensis (wapiti) [GN:
ccad ]
Gene
122449599 APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529 ]
122445384 NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944 ]
122434193 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945 ]
122435278 NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945 ]
122446206 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945 ]
122439822 NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946 ]
122421167 NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947 ]
122450819 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947 ]
122437046 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947 ]
122427449 NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948 ]
122438590 NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949 ]
122453228 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949 ]
122423357 NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950 ]
122440332 NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951 ]
122442112 NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952 ]
122423628 NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953 ]
122437317 NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954 ]
122440280 NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956 ]
122427505 NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352 ]
122440796 NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353 ]
122424053 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957 ]
122434670 LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957 ]
122455060 NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957 ]
122438724 NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958 ]
122426862 NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959 ]
122445595 NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960 ]
122444903 NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961 ]
122453334 NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962 ]
122440564 NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963 ]
122446042 NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964 ]
122451002 NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965 ]
122433010 NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966 ]
122434584 NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351 ]
122430438 NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935 ] [EC:7.1.1.2 ]
122449338 NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936 ] [EC:7.1.1.2 ]
122454277 NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937 ]
122437187 NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938 ]
122454390 NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939 ]
122439962 NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940 ] [EC:7.1.1.2 ]
122431249 NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941 ] [EC:7.1.1.2 ]
122452454 NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial isoform X1 [KO:K03967 ]
122445960 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967 ]
122454570 SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234 ] [EC:1.3.5.1 ]
122426359 SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235 ] [EC:1.3.5.1 ]
122427289 LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
122447513 succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236 ]
122430311 SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236 ]
122453259 succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236 ]
122449644 SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237 ]
122453300 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237 ]
122453299 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like isoform X1 [KO:K00237 ]
122424937 cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414 ]
122445477 LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415 ]
122439251 cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416 ]
122425616 cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416 ]
122437032 cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416 ]
122448767 cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263 ]
122420491 cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263 ]
122441612 cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270 ]
122442248 cytochrome c oxidase subunit 7C, mitochondrial-like isoform X1 [KO:K02272 ]
122448133 ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136 ]
122424880 ATP synthase subunit gamma, mitochondrial-like isoform X1 [KO:K02136 ]
122432978 LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127 ]
122436545 ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127 ]
122438915 LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128 ]
122442942 ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128 ]
122444138 ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128 ]
122443765 ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128 ]
122453549 ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128 ]
122427418 ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128 ]
122428825 ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131 ]
122439923 VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
122446361 VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
122432435 VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
122427232 LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550 ]
122446181 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
122423229 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
122451732 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
122422203 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
122431708 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
122446399 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
122423286 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
122453031 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
122448381 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122448380 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122430651 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122443383 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122442399 GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208 ]
122435222 GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211 ]
122424089 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
122424654 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
122434769 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
122452261 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
122419734 neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809 ]
122446414 MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858 ]
122424343 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
122423671 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
122430102 ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054 ]
122439524 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
122440684 LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237 ]
122443773 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
122423084 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
122443028 PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064 ]
122439694 PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066 ]
122444857 PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028 ]
122426165 PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032 ]
122423948 PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693 ]
122439148 PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035 ]
122449061 PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036 ]
122424779 PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037 ]
122421350 PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038 ]
122430538 PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039 ]
122434578 PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029 ]
122453634 PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030 ]
122420752 PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031 ]
122448123 ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691 ]
122449999 LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741 ] [EC:3.4.22.-]
122427169 natural resistance-associated macrophage protein 2-like [KO:K21398 ]
122427473 LOW QUALITY PROTEIN: natural resistance-associated macrophage protein 2-like [KO:K21398 ]
122427221 natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398 ]
122430564 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
122423049 LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
122446196 DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
122452413 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
122444865 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
122439955 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
122429906 AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722 ]
122446062 LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369 ] [EC:2.7.12.2 ]
122422050 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
122436569 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
122441567 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
122440740 PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
122454626 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
122437038 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
122451688 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
122444906 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
122450447 AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985 ]
122443680 ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889 ]
122454879 ATG2B; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906 ]
122427260 WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908 ]
122433142 WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C16514 Amyloid beta protein 40
C16515 Amyloid beta protein 42
C21011 [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012 [Protein]-N(epsilon)-(carboxyethyl)lysine
Reference
Authors
Dickson DW
Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
Journal
Reference
Authors
Takuma K, Yan SS, Stern DM, Yamada K
Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
Journal
Reference
Authors
Bezprozvanny I, Mattson MP
Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
Journal
Reference
Authors
Holscher C
Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
Journal
Reference
Authors
Bojarski L, Herms J, Kuznicki J
Title
Calcium dysregulation in Alzheimer's disease.
Journal
Reference
Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
Title
Ion channels in the regulation of apoptosis.
Journal
Reference
Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
Journal
Reference
Authors
Tan Y, Deng Y, Qing H
Title
Calcium channel blockers and Alzheimer's disease.
Journal
Reference
Authors
Small DH, Mok SS, Bornstein JC
Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
Journal
Reference
Authors
Parihar MS, Hemnani T
Title
Alzheimer's disease pathogenesis and therapeutic interventions.
Journal
Reference
Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
Title
Presenilin-mediated signal transduction.
Journal
Reference
Authors
Honarnejad K, Herms J
Title
Presenilins: role in calcium homeostasis.
Journal
Reference
Authors
Supnet C, Bezprozvanny I
Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
Journal
Reference
Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
Journal
Reference
Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
Journal
Reference
Authors
Eckert A, Nisbet R, Grimm A, Gotz J
Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
Journal
Reference
Authors
Strickland MR, Holtzman DM
Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
Journal
Reference
Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
Journal
Reference
Authors
Sushma, Mondal AC
Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
Journal
Reference
Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
Journal
Reference
Authors
Mattson MP
Title
ER calcium and Alzheimer's disease: in a state of flux.
Journal
Reference
Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
Journal
Reference
Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
Journal
Reference
Authors
Lane-Donovan C, Herz J
Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
Journal
Reference
Authors
Wasser CR, Herz J
Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
Journal
Reference
Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
Journal
Reference
Authors
Anastasio TJ
Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
Journal
Reference
Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
Journal
Reference
Authors
Tu S, Okamoto S, Lipton SA, Xu H
Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
Journal
Reference
Authors
Palomer E, Buechler J, Salinas PC
Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
Journal
Reference
Authors
Vallee A, Lecarpentier Y
Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
Journal
Reference
Authors
Origlia N, Arancio O, Domenici L, Yan SS
Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
Journal
Reference
Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
Journal
Reference
Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
Journal
Reference
Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
Title
Axonal transport defects: a common theme in neurodegenerative diseases.
Journal
Reference
Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
Journal
Reference
Authors
De Felice FG, Lourenco MV, Ferreira ST
Title
How does brain insulin resistance develop in Alzheimer's disease?
Journal
Reference
Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
Journal
Reference
Authors
Funderburk SF, Marcellino BK, Yue Z
Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
Journal
Related pathway
ccad04141 Protein processing in endoplasmic reticulum
ccad04933 AGE-RAGE signaling pathway in diabetic complications
KO pathway
LinkDB
All DBs