KEGG   PATHWAY: ccad05010
Entry
ccad05010                   Pathway                                
Name
Alzheimer disease - Cervus canadensis (wapiti)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ccad05010  Alzheimer disease
ccad05010

Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122443550  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
122442085  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
122428625  amyloid-beta precursor protein isoform X1 [KO:K04520]
122421052  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
122449599  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
122429816  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
122439480  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
122423367  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
122452169  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
122428616  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
122449404  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
122445355  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
122431157  RTN3; reticulon-3 isoform X1 [KO:K20723]
122441682  RTN4; reticulon-4 isoform X1 [KO:K20720]
122421470  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
122443826  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
122454484  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
122452101  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
122430879  NCSTN; nicastrin isoform X1 [KO:K06171]
122443513  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
122434150  APH1A; gamma-secretase subunit APH-1A isoform X1 [KO:K06172]
122446143  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
122445014  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
122440039  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
59433129  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
59433132  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
59433141  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
59433123  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
59433142  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
59433145  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
59433112  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
122431141  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
122439648  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
122425704  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
122421989  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
122445384  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
122434193  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
122435278  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
122446206  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
122439822  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
122421167  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
122450819  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
122437046  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
122449198  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
122432478  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
122433568  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
122450395  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
122427449  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
122438143  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
122438590  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
122453228  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
122423357  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
122440332  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
122442112  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
122423628  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
122437317  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
122440280  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
122427505  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
122440796  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
122424053  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
122434670  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
122455060  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
122438724  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
122426862  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
122445595  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
122444903  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
122453334  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
122440564  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
122446042  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
122451002  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
122433010  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
122434584  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
122426201  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
122430438  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
122449338  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
122454277  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
122437187  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
122454390  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
122439962  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
122431249  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
122452454  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial isoform X1 [KO:K03967]
122445960  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
122454570  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
122426359  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
122427289  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
122447513  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
122430311  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
122453259  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
122449644  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
122453300  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
122453299  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like isoform X1 [KO:K00237]
122420886  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
59433146  CYTB; cytochrome b [KO:K00412]
122451456  cytochrome c1, heme protein, mitochondrial [KO:K00413]
122424937  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
122432998  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
122445477  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
122439251  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
122425616  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
122437032  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
122423806  cytochrome b-c1 complex subunit 7-like [KO:K00417]
122441814  cytochrome b-c1 complex subunit 7-like [KO:K00417]
122451168  cytochrome b-c1 complex subunit 7-like [KO:K00417]
122450812  cytochrome b-c1 complex subunit 7 [KO:K00417]
122439933  cytochrome b-c1 complex subunit 8 [KO:K00418]
122421203  cytochrome b-c1 complex subunit 9 [KO:K00419]
122439947  cytochrome b-c1 complex subunit 10 [KO:K00420]
59433120  COX3; cytochrome c oxidase subunit III [KO:K02262]
59433137  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
59433139  COX2; cytochrome c oxidase subunit II [KO:K02261]
122448767  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
122420491  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
122455265  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
122441380  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
122451077  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
122434949  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
122433259  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
122422557  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
122420930  cytochrome c oxidase subunit 6B2 [KO:K02267]
122421476  cytochrome c oxidase subunit 6B1 [KO:K02267]
122451325  cytochrome c oxidase subunit 6C [KO:K02268]
122447978  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
122421478  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
122422560  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
122422583  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
122441612  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
122426825  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
122453780  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
122428957  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
122422191  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
122444030  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
122435324  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
122427709  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
122439556  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
122439557  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
122448012  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122448035  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122450590  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122424390  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122423440  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122425524  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122434662  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122428229  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
122442248  cytochrome c oxidase subunit 7C, mitochondrial-like isoform X1 [KO:K02272]
122431334  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
122419635  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
122425554  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
122427238  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
122448133  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
122424880  ATP synthase subunit gamma, mitochondrial-like isoform X1 [KO:K02136]
122439970  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
122448321  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
122423437  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
122428930  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
59433124  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
122432978  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
122436545  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
122438915  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
122442942  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
122444138  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
122443765  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
122453549  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
122427418  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
122441026  ATP synthase subunit d, mitochondrial-like [KO:K02138]
122436557  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
122424303  ATP synthase subunit d, mitochondrial-like [KO:K02138]
122424329  ATP synthase subunit d, mitochondrial-like [KO:K02138]
122430038  ATP synthase subunit O, mitochondrial [KO:K02137]
122428707  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
122428825  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
122428755  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
59433140  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
122434299  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
122453523  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
122439923  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122446361  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
122432435  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
122432310  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
122434361  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
122455040  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
122435311  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
122446452  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
122431880  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
122421688  APOE; apolipoprotein E [KO:K04524]
122427232  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
122446181  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
122423229  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122431085  FADD; FAS-associated death domain protein [KO:K02373]
122426570  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122423034  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
122420755  CALM3; calmodulin-3 [KO:K02183]
122420753  calmodulin-1-like [KO:K02183]
122448900  calmodulin-2/4-like [KO:K02183]
122448285  calmodulin-like [KO:K02183]
122441648  CALM2; calmodulin-2 [KO:K02183]
122453208  calmodulin-1-like [KO:K02183]
122443081  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122451732  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
122443955  CALM1; calmodulin-1 isoform X1 [KO:K02183]
122445547  calmodulin-1 [KO:K02183]
122422203  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122431708  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122446399  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122431959  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122441856  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
122430652  BAD; bcl2-associated agonist of cell death [KO:K02158]
122438479  cytochrome c [KO:K08738]
122440592  cytochrome c [KO:K08738]
122432475  cytochrome c-like [KO:K08738]
122434040  cytochrome c [KO:K08738]
122435448  cytochrome c [KO:K08738]
122443337  cytochrome c-like [KO:K08738]
122453615  cytochrome c [KO:K08738]
122444772  cytochrome c-like [KO:K08738]
122454513  cytochrome c-like [KO:K08738]
122436938  cytochrome c-like [KO:K08738]
122423286  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
122452241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122432443  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122431344  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
122446587  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
122443335  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
122430926  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
122453031  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122448381  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448380  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122430651  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
122443383  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122442399  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
122433444  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
122423939  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122435222  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
122421596  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
122424089  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122424654  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122434769  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122452261  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122419734  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
122446414  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
122447261  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122443334  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
122424343  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122423671  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122430147  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
122433616  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
122447200  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
122423683  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122430102  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
122421504  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
122427416  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
122439524  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
122441770  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
122442423  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122433913  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122440347  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122440572  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122428339  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122446321  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122440684  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
122443773  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
122423084  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122444829  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122455187  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
122438544  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
122439576  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
122455264  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
122448875  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
122425734  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
122436586  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
122450166  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
122421136  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
122443699  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
122436871  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
122446432  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
122442147  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
122445312  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
122437238  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
122443209  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
122433892  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
122434640  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
122438283  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
122443951  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
122421120  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
122443028  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
122453267  26S proteasome regulatory subunit 10B-like [KO:K03064]
122449469  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
122427317  26S proteasome regulatory subunit 6A-like [KO:K03065]
122439694  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
122444857  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
122426165  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
122423948  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
122439148  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
122449061  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
122424779  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
122421350  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
122430538  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
122434578  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
122453634  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
122420752  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
122434167  26S proteasome non-ATPase regulatory subunit 8-like [KO:K03031]
122448123  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
122438119  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
122449999  LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741] [EC:3.4.22.-]
122423224  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
122430944  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
122435630  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
122452395  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
122449104  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
122440207  SLC39A3; zinc transporter ZIP3 [KO:K14709]
122443300  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
122433288  SLC39A1; zinc transporter ZIP1 [KO:K14709]
122451417  SLC39A4; zinc transporter ZIP4 [KO:K14710]
122427299  SLC39A5; zinc transporter ZIP5 isoform X1 [KO:K14711]
122425409  SLC39A6; zinc transporter ZIP6 [KO:K14712]
122429968  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
122422326  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
122443795  SLC39A9; zinc transporter ZIP9 [KO:K14715]
122426191  SLC39A10; zinc transporter ZIP10 [KO:K14716]
122431512  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
122448768  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
122449470  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
122431733  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
122427169  natural resistance-associated macrophage protein 2-like [KO:K21398]
122427473  LOW QUALITY PROTEIN: natural resistance-associated macrophage protein 2-like [KO:K21398]
122427221  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
122445589  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122446263  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122422093  DKK2; dickkopf-related protein 2 isoform X1 [KO:K02165]
122446216  DKK1; dickkopf-related protein 1 [KO:K02165]
122432635  DKK4; dickkopf-related protein 4 [KO:K02165]
122427439  WNT1; proto-oncogene Wnt-1 [KO:K03209]
122436531  WNT2B; protein Wnt-2b [KO:K00182]
122438339  WNT2; protein Wnt-2 [KO:K00182]
122439332  WNT3A; protein Wnt-3a [KO:K00312]
122440141  WNT3; proto-oncogene Wnt-3 [KO:K00312]
122426808  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
122423100  WNT5B; protein Wnt-5b [KO:K00444]
122424423  WNT5A; protein Wnt-5a [KO:K00444]
122426705  WNT6; protein Wnt-6 [KO:K00445]
122423904  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
122425114  WNT7A; protein Wnt-7a [KO:K00572]
122439209  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
122446043  WNT8B; protein Wnt-8b [KO:K00714]
122440612  WNT9A; protein Wnt-9a [KO:K01064]
122440147  WNT9B; protein Wnt-9b [KO:K01064]
122426703  WNT10A; protein Wnt-10a [KO:K01357]
122427584  WNT10B; protein Wnt-10b [KO:K01357]
122449784  WNT11; protein Wnt-11 [KO:K01384]
122438578  WNT16; protein Wnt-16 [KO:K01558]
122426021  FZD7; frizzled-7 [KO:K02432]
122438068  FZD1; frizzled-1 [KO:K02432]
122440461  FZD2; frizzled-2 [KO:K02235]
122453133  FZD3; frizzled-3 isoform X1 [KO:K02329]
122430895  FZD4; frizzled-4 [KO:K02354]
122448204  FZD8; frizzled-8 [KO:K02375]
122426066  FZD5; frizzled-5 [KO:K02375]
122451193  FZD6; frizzled-6 [KO:K02376]
122432799  FZD9; frizzled-9 [KO:K02842]
122454464  FZD10; frizzled-10 [KO:K02842]
122430564  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
122423049  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
122423369  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
122446196  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
122452413  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
122444865  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
122446679  FRAT1; proto-oncogene FRAT1 [KO:K03069]
122446366  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
122447941  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
122420536  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
122429545  CSNK2B; casein kinase II subunit beta [KO:K03115]
122433487  AXIN1; axin-1 isoform X1 [KO:K02157]
122425340  AXIN2; axin-2 isoform X1 [KO:K04385]
122439955  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
122442941  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
122425067  CTNNB1; catenin beta-1 [KO:K02105]
122439725  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
122434839  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122435051  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122435543  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122435544  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122434874  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122435052  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
122448050  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
122453877  KIF5C; kinesin heavy chain [KO:K10396]
122427596  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
122421082  KLC3; kinesin light chain 3 [KO:K10407]
122429140  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
122430785  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
122454760  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
122448202  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
122422249  tubulin alpha-1B chain-like [KO:K07374]
122423885  TUBA8; tubulin alpha-8 chain [KO:K07374]
122455068  tubulin alpha-3 chain isoform X1 [KO:K07374]
122455101  tubulin alpha-3 chain [KO:K07374]
122426664  tubulin alpha-1D chain [KO:K07374]
122426544  tubulin alpha-4A chain [KO:K07374]
122427610  TUBA1B; tubulin alpha-1B chain [KO:K07374]
122427612  tubulin alpha-1A chain [KO:K07374]
122427613  tubulin alpha-1C chain isoform X1 [KO:K07374]
122427692  tubulin alpha-1B chain isoform X1 [KO:K07374]
122448735  TUBB1; tubulin beta-1 chain [KO:K07375]
122421324  tubulin beta-3 chain [KO:K07375]
122440303  TUBB4A; tubulin beta-4A chain [KO:K07375]
122442387  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
122425626  TUBB6; tubulin beta-6 chain [KO:K07375]
122430098  tubulin beta-2A chain [KO:K07375]
122430099  tubulin beta-2B chain [KO:K07375]
122429521  TUBB; tubulin beta chain [KO:K07375]
122429906  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
122430591  HRAS; GTPase HRas isoform X1 [KO:K02833]
122423876  KRAS; GTPase KRas isoform X1 [KO:K07827]
122446047  GTPase KRas [KO:K07827]
122435924  NRAS; GTPase NRas [KO:K07828]
122434589  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122438725  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122425059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122443062  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122440231  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122440910  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122446062  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122435041  NOX1; NADPH oxidase 1 [KO:K08008]
122435269  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
122431172  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
122430633  RELA; transcription factor p65 isoform X1 [KO:K04735]
122422050  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122448629  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
122452326  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122430072  TNF; tumor necrosis factor [KO:K03156]
122438196  IL6; interleukin-6 [KO:K05405]
122442617  IL1A; interleukin-1 alpha [KO:K04383]
122441784  IL1B; interleukin-1 beta [KO:K04519]
122436569  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122422356  SNCA; alpha-synuclein isoform X1 [KO:K04528]
122441567  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
122446045  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122432633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122434540  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122430981  INS; insulin [KO:K04526]
122440366  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122426865  IRS1; insulin receptor substrate 1 [KO:K16172]
122447361  IRS2; insulin receptor substrate 2 [KO:K07187]
122432714  insulin receptor substrate 1-like isoform X1 [KO:K17445]
122435154  IRS4; insulin receptor substrate 4 [KO:K17446]
122440740  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122454626  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122437038  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
122451688  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122445271  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122444906  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122452383  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122454327  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
122444474  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
122427137  ATG101; autophagy-related protein 101 [KO:K19730]
122449629  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
122450898  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
122450447  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
122441395  BECN1; beclin-1 isoform X1 [KO:K08334]
122452489  BECN2; beclin-2 [KO:K08334]
122428189  beclin-1-like isoform X1 [KO:K08334]
122445493  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
122443680  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
122428443  nuclear receptor-binding factor 2-like isoform X1 [KO:K21246]
122446520  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
122425494  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
122431049  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
122454879  ATG2B; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906]
122427260  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
122433142  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
ccad00190  Oxidative phosphorylation
ccad03050  Proteasome
ccad04020  Calcium signaling pathway
ccad04140  Autophagy - animal
ccad04141  Protein processing in endoplasmic reticulum
ccad04210  Apoptosis
ccad04310  Wnt signaling pathway
ccad04910  Insulin signaling pathway
ccad04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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