KEGG   PATHWAY: cdk05010
Entry
cdk05010                    Pathway                                
Name
Alzheimer disease - Camelus dromedarius (Arabian camel)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
cdk05010  Alzheimer disease
cdk05010

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105088967  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
105091236  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X2 [KO:K06059] [EC:3.4.24.86]
105086807  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
105093777  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
105097915  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
105087019  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
105096538  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
105098219  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105090186  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
105099560  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
105101526  RTN3; reticulon-3 isoform X1 [KO:K20723]
105097218  RTN4; reticulon-4 isoform X5 [KO:K20720]
105088052  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
105086131  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
105099573  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
105100135  NCSTN; nicastrin isoform X1 [KO:K06171]
105101793  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
105103177  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
105084233  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
105094476  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
105090432  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
5618953  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
5618961  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
5618962  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
5618958  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
5618955  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
5618957  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
5618963  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
105104414  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105086491  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105105846  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105091110  LOW QUALITY PROTEIN: nucleolin 2-like [KO:K03944]
116150922  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105098104  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105105514  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105088698  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105098308  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105085342  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105091880  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105087580  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105104365  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X2 [KO:K03952]
105091332  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105105383  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105094828  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105091762  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105097420  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105103723  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105096144  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105096996  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105091662  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105099177  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105090315  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105085920  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105085566  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105105974  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105084324  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105096438  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
105099726  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105101950  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105099258  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105100106  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105106884  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105087155  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
105090973  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105102170  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105104129  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105104408  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
116147839  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
116147841  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
105087084  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105097534  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105102189  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105107079  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105100098  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
105094129  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105089357  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
5618965  CYTB; cytochrome b [KO:K00412]
105105005  cytochrome c1, heme protein, mitochondrial [KO:K00413]
105087919  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
105092293  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
105092921  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
105090575  cytochrome b-c1 complex subunit 7 [KO:K00417]
105090190  cytochrome b-c1 complex subunit 8 [KO:K00418]
105099458  cytochrome b-c1 complex subunit 9 [KO:K00419]
105106524  cytochrome b-c1 complex subunit 10 [KO:K00420]
5618954  COX3; cytochrome c oxidase subunit III [KO:K02262]
5618956  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
5618959  COX2; cytochrome c oxidase subunit II [KO:K02261]
105098909  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
105100820  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
105092495  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
105087250  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105092680  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105101997  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105089718  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
105088048  cytochrome c oxidase subunit 6B1 [KO:K02267]
105098744  cytochrome c oxidase subunit 6B2 [KO:K02267]
105090541  cytochrome c oxidase subunit 6C [KO:K02268]
105088079  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
105105462  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105103545  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
105096479  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
105095562  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
116151966  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
116152083  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
105095183  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105086351  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105091350  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
105104113  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
116147347  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
5618964  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
105102044  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105094601  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105095776  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105097572  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105104626  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
105089856  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
105086808  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
5618960  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
105096695  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
105094765  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
105090242  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105092440  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105086434  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105087057  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105084439  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105093951  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
105103090  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105092427  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105094532  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
105095464  APOE; apolipoprotein E [KO:K04524]
105098307  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
105102832  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105098228  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
105104389  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
105099181  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105100737  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
105096001  CALM1; calmodulin-1 [KO:K02183]
105093281  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105104026  CALM3; calmodulin-3 [KO:K02183]
105105602  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105092364  CALM2; calmodulin-2 [KO:K02183]
116147086  calmodulin-like [KO:K02183]
105102643  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105092463  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105089593  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116152568  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116157512  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105101547  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105098528  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105095080  cytochrome c [KO:K08738]
105092650  cytochrome c [KO:K08738]
105097442  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105107056  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105091516  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105088954  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105089979  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105098361  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
105087414  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
105101292  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101500  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X4 [KO:K05858] [EC:3.1.4.11]
105096910  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105106183  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105089056  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105096536  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105104658  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105098957  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105100748  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105093176  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105103284  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105090835  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
105104257  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
105092475  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105090026  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
105093156  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
105102013  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105101373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
105102781  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105095745  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
105102497  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105092786  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105099473  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105100346  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105092320  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105104181  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105106196  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105092037  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105087572  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105091591  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
105094659  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105100625  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105086172  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105091928  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105094163  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
105092322  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105087216  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
105086586  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
105095668  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
105085640  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
105086687  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
105086238  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105101478  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
105092636  PSMB7; proteasome subunit beta type-7 isoform X1 [KO:K02739] [EC:3.4.25.1]
105106941  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105086959  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
105096978  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105093880  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105103219  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105093016  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
105096017  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
105093331  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
105091425  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
105106880  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
105090405  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
105085877  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105093755  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
105099032  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105102519  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X2 [KO:K06693]
105092316  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105088223  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105094369  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105088390  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105105733  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
105103211  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105093692  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X2 [KO:K03030]
105096924  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
105095674  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
105104911  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
105102612  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
105099835  CAPN2; LOW QUALITY PROTEIN: calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105088224  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
105089351  SLC39A1; zinc transporter ZIP1 [KO:K14709]
105097628  SLC39A2; zinc transporter ZIP2 [KO:K14709]
105106055  SLC39A3; zinc transporter ZIP3 isoform X1 [KO:K14709]
105104991  SLC39A4; zinc transporter ZIP4 isoform X2 [KO:K14710]
105086368  SLC39A5; zinc transporter ZIP5 isoform X1 [KO:K14711]
105086883  SLC39A6; zinc transporter ZIP6 [KO:K14712]
105101394  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
105089557  SLC39A8; zinc transporter ZIP8 [KO:K14714]
105086155  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
105088793  SLC39A10; zinc transporter ZIP10 [KO:K14716]
105085686  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
105090612  SLC39A12; LOW QUALITY PROTEIN: zinc transporter ZIP12 [KO:K14718]
105106879  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
105102658  SLC39A14; zinc transporter ZIP14 isoform X1 [KO:K14720]
105107145  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
105105662  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
105090321  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105091687  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
105085258  DKK1; dickkopf-related protein 1 [KO:K02165]
105105283  DKK2; dickkopf-related protein 2 [KO:K02165]
105086433  DKK4; dickkopf-related protein 4 [KO:K02165]
105103785  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105085323  WNT2; protein Wnt-2 [KO:K00182]
105102049  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105094160  WNT3A; protein Wnt-3a [KO:K00312]
105090437  WNT3; proto-oncogene Wnt-3 isoform X2 [KO:K00312]
105088869  WNT4; protein Wnt-4 [KO:K00408]
105102929  WNT5B; protein Wnt-5b [KO:K00444]
105089783  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
105096131  WNT6; LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
105091978  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
105093166  WNT7A; protein Wnt-7a [KO:K00572]
105084321  WNT8B; protein Wnt-8b [KO:K00714]
105090590  WNT8A; protein Wnt-8a [KO:K00714]
105090501  WNT9B; protein Wnt-9b [KO:K01064]
105094161  WNT9A; protein Wnt-9a [KO:K01064]
105103814  WNT10B; protein Wnt-10b [KO:K01357]
105096132  WNT10A; protein Wnt-10a [KO:K01357]
105097257  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
105085333  WNT16; protein Wnt-16 [KO:K01558]
105087377  FZD1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
105098968  FZD7; frizzled-7 [KO:K02432]
105094444  FZD2; frizzled-2 [KO:K02235]
105102079  FZD3; frizzled-3 [KO:K02329]
105097946  FZD4; frizzled-4 [KO:K02354]
105093254  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
105093559  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
105090522  FZD6; frizzled-6 [KO:K02376]
105092660  FZD10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
105089729  FZD9; frizzled-9 [KO:K02842]
105094238  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
105104473  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
105091951  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
105085889  DVL3; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
105105575  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
105103047  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105084375  FRAT1; proto-oncogene FRAT1 [KO:K03069]
116155842  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
105093799  CSNK2A2; casein kinase II subunit alpha' isoform X2 [KO:K03097] [EC:2.7.11.1]
105100805  CSNK2A1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105087463  CSNK2B; casein kinase II subunit beta [KO:K03115]
105098424  AXIN1; axin-1 isoform X1 [KO:K02157]
105085712  AXIN2; axin-2 isoform X1 [KO:K04385]
105095381  APC; adenomatous polyposis coli protein isoform X4 [KO:K02085]
105104128  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
105084622  CTNNB1; catenin beta-1 [KO:K02105]
105088938  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
105097024  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
105084640  KIF5C; LOW QUALITY PROTEIN: kinesin heavy chain [KO:K10396]
105100340  KIF5A; kinesin heavy chain isoform X3 [KO:K10396]
105086860  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
105088615  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105102569  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
105105985  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
105095455  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
105096109  TUBA4A; tubulin alpha-4A chain [KO:K07374]
105095310  tubulin alpha-1A chain-like [KO:K07374]
105100732  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105091377  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105095227  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
116150045  tubulin alpha-3 chain [KO:K07374]
105095224  tubulin alpha-3 chain [KO:K07374]
116150047  tubulin alpha-3 chain-like [KO:K07374]
105089297  tubulin alpha-1A chain-like [KO:K07374]
116147140  tubulin alpha-1C chain-like [KO:K07374]
105096135  tubulin alpha-1D chain isoform X1 [KO:K07374]
105103777  TUBA1C; LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
105103779  LOW QUALITY PROTEIN: tubulin alpha-1B chain [KO:K07374]
105087494  TUBB; tubulin beta chain isoform X2 [KO:K07375]
105087583  LOW QUALITY PROTEIN: tubulin beta-2A chain [KO:K07375]
105098536  tubulin beta-2B chain [KO:K07375]
105086496  TUBB6; LOW QUALITY PROTEIN: tubulin beta-6 chain [KO:K07375]
105104555  TUBB4A; tubulin beta-4A chain [KO:K07375]
105105754  tubulin beta-2A chain [KO:K07375]
105104356  TUBB3; tubulin beta-3 chain [KO:K07375]
105105106  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
105095658  TUBB1; tubulin beta-1 chain [KO:K07375]
116151533  tubulin beta chain-like [KO:K07375]
116151371  tubulin beta chain-like [KO:K07375]
105090848  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
105105427  HRAS; GTPase HRas isoform X1 [KO:K02833]
105100066  KRAS; GTPase KRas isoform X1 [KO:K07827]
105089630  NRAS; GTPase NRas [KO:K07828]
105102848  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
105091663  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105085500  NOX1; NADPH oxidase 1 [KO:K08008]
105101594  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
105088593  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
105102595  RELA; transcription factor p65 isoform X1 [KO:K04735]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105088198  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
105099289  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105087473  TNF; tumor necrosis factor [KO:K03156]
105095065  IL6; interleukin-6 [KO:K05405]
105093151  IL1A; interleukin-1 alpha [KO:K04383]
105093155  IL1B; interleukin-1 beta [KO:K04519]
105085658  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
105102811  SNCA; alpha-synuclein [KO:K04528]
105105818  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
105084316  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105086448  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105106603  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116152037  INS; insulin [KO:K04526]
105087555  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105088301  IRS1; insulin receptor substrate 1 [KO:K16172]
116157131  IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
105105271  insulin receptor substrate 2-B-like isoform X1 [KO:K17445]
105099556  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105092913  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105107024  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105094622  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105085092  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
105100387  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
105106863  ATG13; autophagy-related protein 13 isoform X3 [KO:K08331]
105097068  RB1CC1; LOW QUALITY PROTEIN: RB1-inducible coiled-coil protein 1 [KO:K17589]
105106861  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
105099268  BECN2; beclin-2 [KO:K08334]
105090478  BECN1; beclin-1 isoform X1 [KO:K08334]
105088768  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
105091474  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
105093862  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
105085253  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105095494  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105102629  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
105085704  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
105104243  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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pathway
cdk00190  Oxidative phosphorylation
cdk03050  Proteasome
cdk04020  Calcium signaling pathway
cdk04140  Autophagy - animal
cdk04141  Protein processing in endoplasmic reticulum
cdk04210  Apoptosis
cdk04310  Wnt signaling pathway
cdk04910  Insulin signaling pathway
cdk04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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