KEGG   PATHWAY: gcl04010
Entry
gcl04010                    Pathway                                
Name
MAPK signaling pathway - Gymnogyps californianus (California condor)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
gcl04010  MAPK signaling pathway
gcl04010

Other DBs
GO: 0000165
Organism
Gymnogyps californianus (California condor) [GN:gcl]
Gene
127023860  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
127013811  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
127021725  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
127019051  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
127024060  voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
127022665  voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
127013847  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
127026378  voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
127014860  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
127021534  voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
127021634  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
127020501  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
127026434  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
127013396  voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
127018265  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
127024146  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
127027610  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
127022502  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
127024143  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
127024145  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
127019058  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
127024139  LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
127022394  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127022239  guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
127018969  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
127025276  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
127018001  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127015470  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127014414  calcineurin subunit B type 1 isoform X1 [KO:K06268]
127020403  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
127027137  ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
127017152  RAS guanyl-releasing protein 1 [KO:K04350]
127014499  ras guanyl-releasing protein 3 [KO:K12362]
127015409  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127024407  neurofibromin isoform X1 [KO:K08052]
127027445  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
127029121  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
127020194  ras GTPase-activating protein 2 isoform X1 [KO:K08053]
127026377  ras-related protein Rap-1A [KO:K04353]
127015780  ras-related protein Rap-1b [KO:K07836]
127015786  pro-epidermal growth factor [KO:K04357]
127025252  protransforming growth factor alpha [KO:K08774]
127015800  proepiregulin isoform X1 [KO:K09784]
127015799  LOW QUALITY PROTEIN: amphiregulin [KO:K09782]
127021988  fibroblast growth factor 1 isoform X1 [KO:K18496]
127015769  fibroblast growth factor 2 [KO:K18497]
127017269  fibroblast growth factor 3 [KO:K04358]
127017294  fibroblast growth factor 4 [KO:K04358]
127023419  fibroblast growth factor 9 [KO:K04358]
127025386  fibroblast growth factor 17 [KO:K04358]
127017921  fibroblast growth factor 8 isoform X1 [KO:K04358]
127019746  fibroblast growth factor 16 [KO:K04358]
127027532  fibroblast growth factor 10 [KO:K04358]
127020521  fibroblast growth factor 7 isoform X1 [KO:K04358]
127028863  fibroblast growth factor 10-like [KO:K04358]
127029421  fibroblast growth factor 6 [KO:K04358]
127015945  LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
127022034  fibroblast growth factor 18 [KO:K04358]
127015893  fibroblast growth factor 5 [KO:K04358]
127017342  fibroblast growth factor 19 [KO:K22603]
127029574  fibroblast growth factor 23 [KO:K22428]
127026306  beta-nerve growth factor [KO:K02582]
127016890  brain-derived neurotrophic factor [KO:K04355]
127025335  neurotrophin-3 [KO:K04356]
127017343  insulin [KO:K04526]
127023592  insulin-like growth factor I [KO:K05459]
127016930  insulin-like growth factor II [KO:K13769]
127022335  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
127029754  platelet-derived growth factor subunit B [KO:K17386]
127015740  platelet-derived growth factor C [KO:K05450]
127023694  platelet-derived growth factor D isoform X1 [KO:K05450]
127026222  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
127022954  kit ligand isoform X1 [KO:K05461]
127014802  vascular endothelial growth factor A isoform X1 [KO:K05448]
127016909  placenta growth factor [KO:K16859]
127020234  vascular endothelial growth factor D [KO:K05449]
127015984  LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
127022227  hepatocyte growth factor [KO:K05460]
127013248  angiopoietin-1 [KO:K05465]
127014241  angiopoietin-2 isoform X1 [KO:K05466]
127025552  ephrin-A2 [KO:K05462]
127027117  ephrin-A5 isoform X1 [KO:K05462]
127019764  glial cell line-derived neurotrophic factor-like isoform X1 [KO:K05452]
127027667  glial cell line-derived neurotrophic factor [KO:K05452]
127025659  neurturin [KO:K25414]
127019293  artemin isoform X1 [KO:K25415]
127029897  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
127018190  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
127025218  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
127017543  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
127015502  fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
127021795  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
127026568  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
127026894  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
127027121  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
127027278  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
127025531  insulin receptor [KO:K04527] [EC:2.7.10.1]
127020876  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
127015473  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
127021839  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
127022114  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
127016029  mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
127024685  receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
127019484  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
127015031  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
127021875  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
127015909  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
127015665  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
127027523  angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
127024879  LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
127017854  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
127024217  growth factor receptor-bound protein 2 [KO:K04364]
127016829  son of sevenless homolog 2 isoform X1 [KO:K03099]
127014152  son of sevenless homolog 1 isoform X1 [KO:K03099]
127016479  GTPase HRas [KO:K02833]
127028489  GTPase KRas isoform X1 [KO:K07827]
127026157  GTPase NRas [KO:K07828]
127016572  ras-related protein R-Ras2 [KO:K07830]
127018403  ras-related protein M-Ras [KO:K07831]
127014379  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
127021590  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
127020580  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127025478  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
127015443  ragulator complex protein LAMTOR3 [KO:K04370]
127022713  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127025420  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
127019215  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
127025060  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
127025932  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025933  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025934  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025935  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025937  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025941  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025955  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025991  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127025997  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127026002  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127026004  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127026015  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127026017  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127026018  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127026020  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127014138  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
127019496  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
127029722  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
127028956  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
127026230  ETS domain-containing protein Elk-4 [KO:K04376]
127013024  myc proto-oncogene protein [KO:K04377]
127014933  serum response factor isoform X1 [KO:K04378]
127017203  protein c-Fos [KO:K04379]
127026480  microtubule-associated protein tau isoform X1 [KO:K04380]
127025033  stathmin [KO:K04381]
127016789  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
127017412  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
127019327  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127016363  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
127016364  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
127016365  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
127016377  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
127016518  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
127025338  interleukin-1 beta-like [KO:K04519]
127028058  transforming growth factor beta-1 proprotein [KO:K13375]
127014818  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
127017011  LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
127019183  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
127013124  interleukin-1 receptor type 1-like [KO:K04386]
127020238  interleukin-1 receptor accessory protein [KO:K04723]
127029943  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
127012761  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
127018314  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
127019368  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
127017876  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
127022202  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
127014973  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
127024674  cell division control protein 42 homolog isoform X1 [KO:K04393]
127021183  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
127015618  caspase-3 [KO:K02187] [EC:3.4.22.56]
127023695  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
127012707  myeloid differentiation primary response protein MyD88 [KO:K04729]
127020686  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
127017259  TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
127019180  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
127027416  growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
127029449  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
127014098  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
127014090  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
127019832  nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
127029764  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
127014044  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
127020298  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
127023236  serine/threonine-protein kinase 4 [KO:K04411]
127012625  serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
127013069  mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
127027572  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
127027897  mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
127018205  mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
127026479  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
127013622  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
127016522  mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
127014717  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
127020068  mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
127018173  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
127024957  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
127014170  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
127014135  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
127014121  mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
127024291  serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
127022696  serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
127023978  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
127022624  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
127023976  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
127016621  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
127022218  C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
127024339  adapter molecule crk isoform X1 [KO:K04438]
127022833  crk-like protein isoform X1 [KO:K04438]
127026456  beta-arrestin-1 [KO:K04439]
127022185  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127017578  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127015438  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127022393  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
127026124  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
127026219  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
127022746  MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
127026329  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
127021398  MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
127016459  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
127028859  M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
127013295  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
127021349  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127019308  transcription factor Jun [KO:K04448]
127025632  transcription factor JunD [KO:K04449]
127018309  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
127028534  DNA damage-inducible transcript 3 protein [KO:K04452]
127017393  protein max isoform X1 [KO:K04453]
127027086  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
127028973  myocyte-specific enhancer factor 2C-like [KO:K04454]
127024384  heat shock protein beta-1 [KO:K04455]
127016681  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127014696  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127017413  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
127021675  receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
127017179  tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
127026288  tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
127022068  dual specificity protein phosphatase 1 isoform X1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
127016879  LOW QUALITY PROTEIN: dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127017091  dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127017711  dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127021473  dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127016316  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127018011  dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
127014780  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
127026446  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
127015061  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
127025779  heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
127020044  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
127020448  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
127026455  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
127017902  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
127025388  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
127024618  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
127015466  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
127017533  nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
gcl04070  Phosphatidylinositol signaling system
gcl04110  Cell cycle
gcl04115  p53 signaling pathway
gcl04210  Apoptosis
gcl04310  Wnt signaling pathway
KO pathway
ko04010   
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