KEGG   PATHWAY: ocu04810
Entry
ocu04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Oryctolagus cuniculus (rabbit)
Class
Cellular Processes; Cell motility
Pathway map
ocu04810  Regulation of actin cytoskeleton
ocu04810

Other DBs
GO: 0030036
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100355169  lysophosphatidic acid receptor 1 [KO:K04289]
100343700  lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
100344512  lysophosphatidic acid receptor 4 [KO:K04275]
100347657  lysophosphatidic acid receptor 5 [KO:K08390]
103345545  stromal cell-derived factor 1 isoform X1 [KO:K10031]
100346189  C-X-C chemokine receptor type 4 [KO:K04189]
100009146  prothrombin [KO:K01313] [EC:3.4.21.5]
100351711  proteinase-activated receptor 1 [KO:K03914]
100008808  pro-epidermal growth factor [KO:K04357]
100328898  FGF1; fibroblast growth factor 1 [KO:K18496]
100009068  fibroblast growth factor 2 [KO:K18497]
100342802  fibroblast growth factor 10 [KO:K04358]
103345488  fibroblast growth factor 17 isoform X1 [KO:K04358]
100340478  fibroblast growth factor 18 [KO:K04358]
100316906  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100008681  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
100346367  fibroblast growth factor 6 [KO:K04358]
100355861  fibroblast growth factor 9 [KO:K04358]
100342742  fibroblast growth factor 16 [KO:K04358]
100008834  fibroblast growth factor 8 isoform X1 [KO:K04358]
100356340  fibroblast growth factor 21 [KO:K22429]
100343050  fibroblast growth factor 23 [KO:K22428]
100352388  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100358772  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100350272  platelet-derived growth factor C [KO:K05450]
100008912  PDGFD; platelet-derived growth factor D [KO:K05450]
100338576  insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
100008806  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100351861  fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100009417  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
127485863  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100355275  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100343006  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100342872  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100328589  FN1; fibronectin isoform X1 [KO:K05717]
100342711  integrin alpha-1 [KO:K06480]
100101621  integrin alpha-2 [KO:K06481]
100008734  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100348594  integrin alpha-3 [KO:K06482]
100346103  integrin alpha-4 isoform X1 [KO:K06483]
100009172  integrin alpha-5 [KO:K06484]
100008642  integrin alpha-6 isoform X1 [KO:K06485]
100346005  integrin alpha-7 isoform X6 [KO:K06583]
127487418  integrin alpha-7 isoform X1 [KO:K06583]
100351181  integrin alpha-8 [KO:K06584]
100339625  integrin alpha-9 [KO:K06585]
103350383  integrin alpha-9 [KO:K06585]
100340248  integrin alpha-10 isoform X1 [KO:K06586]
100344251  integrin alpha-11 [KO:K06587]
100008956  integrin alpha-V isoform X1 [KO:K06487]
100356927  integrin alpha-L isoform X1 [KO:K05718]
100351865  integrin alpha-M isoform X1 [KO:K06461]
100351616  integrin alpha-X isoform X1 [KO:K06462]
100351363  integrin alpha-D isoform X1 [KO:K06594]
100355227  integrin alpha-E isoform X1 [KO:K06524]
100008898  integrin beta-1 isoform X2 [KO:K05719]
100339049  integrin beta-2 [KO:K06464]
100008735  ITGB3; integrin beta-3 precursor [KO:K06493]
100101587  LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100353546  integrin beta-5 [KO:K06588]
100338232  integrin beta-6 isoform X1 [KO:K06589]
100350557  integrin beta-7 isoform X1 [KO:K06590]
100009141  ITGB8; integrin beta-8 precursor [KO:K06591]
100101602  kininogen-1 isoform X1 [KO:K03898]
100009198  BDKRB1; B1 bradykinin receptor [KO:K03915]
100338359  B2 bradykinin receptor isoform X1 [KO:K03916]
100346573  muscarinic acetylcholine receptor M1 [KO:K04129]
100342878  muscarinic acetylcholine receptor M2 [KO:K04130]
100355313  muscarinic acetylcholine receptor M3 [KO:K04131]
100008791  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
127486600  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M4-like [KO:K04132]
100342984  muscarinic acetylcholine receptor M5 [KO:K04133]
103352022  complement C5 isoform X1 [KO:K03994]
103352041  LOW QUALITY PROTEIN: complement C5 [KO:K03994]
100359210  complement component C6 [KO:K03995]
100358949  complement component C7 [KO:K03996]
100009076  C8A; complement component C8 alpha chain precursor [KO:K03997]
100009385  C8B; complement component C8 beta chain precursor [KO:K03998]
100009197  C9; complement component C9 precursor [KO:K04000]
100347293  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100352794  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
108176185  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
103350153  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100349862  FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
100358225  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
100347455  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100350323  breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
100342327  crk-like protein [KO:K04438]
100342405  dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
100341599  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100356615  son of sevenless homolog 1 isoform X1 [KO:K03099]
100346391  son of sevenless homolog 2 isoform X1 [KO:K03099]
127486605  GTPase HRas isoform X1 [KO:K02833]
100347487  GTPase KRas isoform X1 [KO:K07827]
127489236  GTPase KRas-like [KO:K07827]
100344241  GTPase NRas [KO:K07828]
127489362  ras-related protein R-Ras [KO:K07829]
100355920  ras-related protein R-Ras2 [KO:K07830]
100358182  ras-related protein M-Ras isoform X1 [KO:K07831]
100358647  rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
100348663  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100345181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100337822  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100357841  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100345250  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100341627  guanine nucleotide exchange factor VAV3 [KO:K05730]
100338333  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100340437  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100351964  serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100347407  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100356433  proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100342852  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100353706  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127486116  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100352761  regulator of cell cycle RGCC [KO:K26108]
103347573  rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100340118  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100356673  rho GTPase-activating protein 35 [KO:K05732]
100356250  transforming protein RhoA [KO:K04513]
100348967  transforming protein RhoA-like [KO:K04513]
100340661  transforming protein RhoA [KO:K04513]
100346856  LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
100343368  transforming protein RhoA-like [KO:K04513]
100343680  transforming protein RhoA-like [KO:K04513]
127489660  transforming protein RhoA-like [KO:K04513]
100339873  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100356520  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100008965  cell division control protein 42 homolog isoform X1 [KO:K04393]
100344482  cell division control protein 42 homolog [KO:K04393]
100352056  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100009535  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100347273  serine/threonine-protein kinase PAK 3 isoform X2 [KO:K05733] [EC:2.7.11.1]
100341934  serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
100340742  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100348921  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103346536  rho guanine nucleotide exchange factor 7 [KO:K13710]
103346864  rho guanine nucleotide exchange factor 7 [KO:K13710]
127486000  rho guanine nucleotide exchange factor 7-like [KO:K13710]
100347771  ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
100009220  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100346837  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100009051  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100353972  myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100348694  myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
127493971  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
100009587  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100009298  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100353054  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100350558  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100356902  protein phosphatase 1 regulatory subunit 12B isoform X8 [KO:K12329]
100353304  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
127492634  myosin regulatory light chain 2, atrial isoform [KO:K12754]
100343384  myosin regulatory light polypeptide 9 [KO:K12755]
100341579  myosin regulatory light chain 10 [KO:K12756]
100345591  myosin regulatory light chain 12B [KO:K12757]
100346112  LOW QUALITY PROTEIN: myosin regulatory light polypeptide 9 [KO:K12757]
100009542  MYL11; myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
100009001  myosin-9 [KO:K10352]
100009002  myosin-10 isoform X3 [KO:K10352]
100009145  MYH11; myosin-11 [KO:K10352]
100354169  protein diaphanous homolog 1 [KO:K05740]
100347936  protein diaphanous homolog 2 isoform X1 [KO:K05741]
100009586  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103350059  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
100356255  phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
127485993  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100344769  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
100340683  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
100352034  phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
100357384  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100344018  LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
100356835  LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
100344823  protein diaphanous homolog 3 isoform X1 [KO:K05745]
100351936  protein enabled homolog isoform X1 [KO:K05746]
100347053  actin nucleation-promoting factor WASL isoform X1 [KO:K23612]
100355636  actin-binding protein WASF2 [KO:K05748]
100339839  cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
100352485  cytoplasmic FMR1-interacting protein 2 isoform X2 [KO:K05749]
100340824  nck-associated protein 1-like isoform X1 [KO:K05750]
100337891  nck-associated protein 1 isoform X3 [KO:K05750]
100356964  abl interactor 2 isoform X15 [KO:K05751]
100357320  LOW QUALITY PROTEIN: abl interactor 2-like [KO:K05751]
100346065  protein BRICK1 [KO:K05752]
100348657  actin-binding protein WASF1 isoform X1 [KO:K05753]
100339213  actin-related protein 2 [KO:K17260]
100343474  actin-related protein 3B isoform X2 [KO:K18584]
100008790  actin-related protein 3 isoform X2 [KO:K18584]
100358336  actin-related protein 3 [KO:K18584]
100346759  actin-related protein 2/3 complex subunit 1B [KO:K05757]
100347020  actin-related protein 2/3 complex subunit 1A [KO:K05757]
100349913  actin-related protein 2/3 complex subunit 2 [KO:K05758]
100357607  actin-related protein 2/3 complex subunit 3 [KO:K05756]
103345506  actin-related protein 2/3 complex subunit 4 [KO:K05755]
127485982  actin-related protein 2/3 complex subunit 4 [KO:K05755]
100344359  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103346289  actin-related protein 2/3 complex subunit 5 [KO:K05754]
100008822  actin, cytoplasmic 1 [KO:K05692]
100009272  ACTB; actin, cytoplasmic 1 [KO:K05692]
100341037  LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [KO:K05692]
100356070  profilin-1 [KO:K05759]
100357380  profilin-3 [KO:K05759]
100340735  profilin-4 [KO:K05759]
100350198  profilin-1 [KO:K05759]
100358541  profilin-2 isoform X1 [KO:K05759]
100353305  paxillin isoform X5 [KO:K05760]
100008846  EZR; ezrin [KO:K08007]
100341234  radixin isoform X1 [KO:K05762]
100338273  moesin [KO:K05763]
103348079  LOW QUALITY PROTEIN: moesin-like [KO:K05763]
127485645  thymosin beta-4 [KO:K05764]
100359205  LOW QUALITY PROTEIN: cofilin-2 [KO:K05765]
100341589  cofilin-1 [KO:K05765]
108178303  cofilin-2 isoform X1 [KO:K05765]
100356755  protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100341119  protein phosphatase Slingshot homolog 2 isoform X5 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100353500  protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100357160  vinculin isoform X1 [KO:K05700]
100344867  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100008918  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
100338069  ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
100337841  gelsolin isoform X1 [KO:K05768]
100355795  scinderin isoform X1 [KO:K05768]
100351066  alpha-actinin-4 isoform X1 [KO:K05699]
100341378  alpha-actinin-1 isoform X1 [KO:K05699]
100353976  adenomatous polyposis coli protein isoform X1 [KO:K02085]
103346018  LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
127485674  adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100338395  rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
100354861  spermatogenesis-associated protein 13 isoform X2 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ocu04010  MAPK signaling pathway
ocu04510  Focal adhesion
ocu04520  Adherens junction
KO pathway
ko04810   
LinkDB

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