KEGG   ORTHOLOGY: K04467Help
Entry
K04467                      KO                                     

Name
IKBKA, IKKA, CHUK
Definition
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04068  FoxO signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04920  Adipocytokine signaling pathway
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05135  Yersinia infection
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05212  Pancreatic cancer
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00882  Cocoon syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04010 MAPK signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04064 NF-kappa B signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04668 TNF signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04068 FoxO signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04151 PI3K-Akt signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04150 mTOR signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04621 NOD-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04622 RIG-I-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04623 Cytosolic DNA-sensing pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04625 C-type lectin receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04660 T cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04658 Th1 and Th2 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04659 Th17 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04657 IL-17 signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04662 B cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04062 Chemokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05221 Acute myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05220 Chronic myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05215 Prostate cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05222 Small cell lung cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05130 Pathogenic Escherichia coli infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05131 Shigellosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05135 Yersinia infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05170 Human immunodeficiency virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05162 Measles
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05164 Influenza A
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05161 Hepatitis B
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05160 Hepatitis C
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05168 Herpes simplex virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05163 Human cytomegalovirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05169 Epstein-Barr virus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05165 Human papillomavirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
BRITE hierarchy
Other DBs
GO: 0008384
Genes
HSA: 1147(CHUK)
PTR: 450673(CHUK)
PPS: 100995228(CHUK)
GGO: 101137405(CHUK) 109025098 109025411
PON: 100174735(CHUK)
NLE: 100596225(CHUK)
MCC: 709511(CHUK)
MCF: 102115964(CHUK)
CSAB: 103216382(CHUK)
RRO: 104656469(CHUK)
RBB: 108535077(CHUK)
SBQ: 101044006(CHUK)
MMU: 12675(Chuk)
MCAL: 110285285(Chuk)
MPAH: 110334538(Chuk)
RNO: 309361(Chuk)
MUN: 110552966(Chuk)
CGE: 100754432(Chuk)
NGI: 103743976(Chuk)
HGL: 101719306(Chuk)
CCAN: 109681514(Chuk)
OCU: 100355888(CHUK)
TUP: 102501308(CHUK)
CFA: 477796(CHUK)
VVP: 112914804(CHUK)
AML: 100464675(CHUK)
UMR: 103658916(CHUK)
UAH: 113251823(CHUK)
ORO: 101364103(CHUK)
FCA: 101095617(CHUK)
PTG: 102949289(CHUK)
AJU: 106966935(CHUK)
BTA: 281073(CHUK)
BOM: 102281886(CHUK)
BIU: 109553086(CHUK)
BBUB: 102399613(CHUK)
PHD: 102332461(CHUK)
CHX: 102181262(CHUK)
OAS: 101111143(CHUK)
SSC: 100135662(CHUK)
CFR: 102503497(CHUK)
CDK: 105084316(CHUK)
BACU: 103015414(CHUK)
LVE: 103085220(CHUK)
OOR: 101281072(CHUK)
DLE: 111172396(CHUK)
PCAD: 102977668(CHUK)
ECB: 100070393(CHUK)
EPZ: 103567228(CHUK)
EAI: 106846705(CHUK)
MYB: 102261467(CHUK)
MYD: 102760888(CHUK)
MNA: 107542599(CHUK)
HAI: 109379632(CHUK)
RSS: 109443941(CHUK)
DRO: 112300474(CHUK)
PALE: 102879469(CHUK)
RAY: 107499756(CHUK)
LAV: 100664361(CHUK)
TMU: 101341290
MDO: 100027952(CHUK)
SHR: 100913624(CHUK)
PCW: 110213919(CHUK)
OAA: 100082351(CHUK)
GGA: 423669(CHUK)
MGP: 100542478(CHUK)
CJO: 107315625(CHUK)
NMEL: 110390496(CHUK)
ACYG: 106030064(CHUK)
TGU: 100221281(CHUK) 100224042
LSR: 110474031(CHUK)
SCAN: 103814234(CHUK)
GFR: 102042264(CHUK)
FAB: 101812706(CHUK)
PHI: 102107801(CHUK)
PMAJ: 107206726(CHUK)
CCAE: 111931619
CCW: 104695067(CHUK)
ETL: 114067570(CHUK)
FPG: 101914413(CHUK)
FCH: 102053491(CHUK)
CLV: 102084658(CHUK)
EGZ: 104125140(CHUK)
NNI: 104013582
ACUN: 113481883(CHUK)
PADL: 103924297(CHUK)
AAM: 106495295(CHUK)
ASN: 102374729(CHUK)
AMJ: 106736873(CHUK)
PSS: 102454064(CHUK)
CMY: 102932800(CHUK)
CPIC: 101931080(CHUK)
ACS: 100565922(chuk)
PVT: 110087236(CHUK)
PBI: 103061898(CHUK)
PMUR: 107291445(CHUK) 114923654
GJA: 107117758(CHUK)
XLA: 444556(chuk.S)
XTR: 101732839 549654(chuk)
NPR: 108797654(CHUK)
DRE: 393287(chuk)
CCAR: 109092137 109100658(chuk)
IPU: 108263650(chuk)
PHYP: 113542836(chuk)
AMEX: 103033415(chuk)
EEE: 113582078(chuk)
MALB: 109961044 109962729(kctd2)
SFM: 108933554(chuk)
PKI: 111836749(chuk)
LCM: 102361819(CHUK)
CMK: 103181859(chuk)
SKO: 102806810
ZNE: 110838212
FCD: 110852083
PCAN: 112557750
MYI: 110456994
EPA: 110254140
HMG: 100207607
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9244310
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell 90:373-83 (1997)
DOI:10.1016/S0092-8674(00)80344-X
  Sequence
[hsa:1147]
Reference
  Authors
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G
  Title
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
  Journal
Sci Signal 3:ra41 (2010)
DOI:10.1126/scisignal.2000778
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