KEGG   DRUG: Sorafenib tosylate
Entry
D06272                      Drug                                   
Name
Sorafenib tosylate (USAN);
Sorafenib tosilate (JAN);
Nexavar (TN)
Product
NEXAVAR (Bayer HealthCare Pharmaceuticals)
  Generic
SORAFENIB (Dr.Reddys Laboratories), SORAFENIB (Golden State Medical Supply), SORAFENIB (TWi Pharmaceuticals USA), SORAFENIB (Teva Pharmaceuticals), SORAFENIB (Torrent Pharmaceuticals Limited), SORAFENIB (Yabao Pharmaceutical), SORAFENIB TOSYLATE (Mylan Pharmaceuticals)
Formula
C21H16ClF3N4O3. C7H8O3S
Exact mass
636.1057
Mol weight
637.0266
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
Remark
Therapeutic category: 4291
ATC code: L01EX02
Chemical structure group: DG00713
Product (DG00713): D06272<JP/US>
Efficacy
Antineoplastic, Tyrosine kinase inhibitor
  Disease
Hepatocellular carcinoma [DS:H00048]
Renal cell carcinoma [DS:H00021]
Thyroid carcinoma [DS:H00032]
Target
RAF1 [HSA:5894] [KO:K04366]
BRAF [HSA:673] [KO:K04365]
FLT3 (CD135) [HSA:2322] [KO:K05092]
PDGFRB [HSA:5159] [KO:K05089]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
RET [HSA:5979] [KO:K05126]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
hsa05211  Renal cell carcinoma
hsa05216  Thyroid cancer
hsa05225  Hepatocellular carcinoma
Interaction
Structure map
map07045  Antineoplastics - protein kinase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX02 Sorafenib
      D06272  Sorafenib tosylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Sorafenib
    D06272  Sorafenib tosylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06272  Sorafenib tosylate (USAN); Sorafenib tosilate (JAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG00713  Sorafenib
    D06272  Sorafenib tosylate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   TKL group
    BRAF
     D06272  Sorafenib tosylate (USAN) <JP/US>
    RAF1
     D06272  Sorafenib tosylate (USAN) <JP/US>
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFRB
     D06272  Sorafenib tosylate (USAN) <JP/US>
    KIT (CD117)
     D06272  Sorafenib tosylate (USAN) <JP/US>
    FLT3 (CD135)
     D06272  Sorafenib tosylate (USAN) <JP/US>
   VEGFR family
    VEGFR2 (KDR)
     D06272  Sorafenib tosylate (USAN) <JP/US>
    VEGFR3 (FLT4)
     D06272  Sorafenib tosylate (USAN) <JP/US>
   RET family
    RET
     D06272  Sorafenib tosylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06272
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06272
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06272
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06272
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG00713  Sorafenib
Other DBs
CAS: 475207-59-1
PubChem: 47207930
LigandBox: D06272
LinkDB
KCF data

ATOM        43
            1   C8y C    41.3134  -16.2561
            2   C8x C    40.1203  -16.9579
            3   C8x C    42.5767  -16.9579
            4   S4a S    41.3134  -14.8525
            5   C8x C    40.1203  -18.3616
            6   C8x C    42.5767  -18.3616
            7   O1d O    39.9098  -14.8525
            8   O1d O    42.7170  -14.8525
            9   O1d O    41.3134  -13.5191
            10  C8y C    41.3134  -19.0634
            11  C1a C    41.2961  -20.4669
            12  C8x C    34.7102  -17.2381
            13  C8y C    34.7102  -18.6418
            14  C8x C    35.9257  -19.3436
            15  C8x C    37.1414  -18.6418
            16  C8y C    37.1414  -17.2381
            17  C8y C    35.9257  -16.5363
            18  X   Cl   38.3757  -16.5253
            19  C1d C    35.9257  -15.1329
            20  X   F    35.9383  -13.7295
            21  N1b N    33.4946  -19.3436
            22  C5a C    32.2961  -18.6514
            23  N1b N    31.1056  -19.3387
            24  O5a O    32.2960  -17.2384
            25  C8y C    29.9113  -18.6489
            26  C8x C    29.9113  -17.2383
            27  C8x C    28.6958  -16.5365
            28  C8y C    27.4802  -17.2383
            29  C8x C    27.4801  -18.6488
            30  C8x C    28.6957  -19.3507
            31  O2a O    26.2656  -16.5369
            32  C8y C    25.0675  -17.2288
            33  C8x C    23.8769  -16.5413
            34  C8y C    22.6613  -17.2431
            35  N5x N    22.6613  -18.6468
            36  C8x C    23.8519  -19.3342
            37  C8x C    25.0675  -18.6324
            38  C5a C    21.4269  -16.5303
            39  N1b N    20.2231  -17.2254
            40  O5a O    21.4271  -15.1328
            41  C1a C    19.0354  -16.5396
            42  X   F    34.5100  -15.1267
            43  X   F    37.3099  -15.1389
BOND        45
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    6  10 2
            11   10  11 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   15  16 1
            16   16  17 2
            17   12  17 1
            18   16  18 1
            19   17  19 1
            20   19  20 1
            21   13  21 1
            22   21  22 1
            23   22  23 1
            24   22  24 2
            25   23  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   25  30 1
            32   28  31 1
            33   31  32 1
            34   32  33 2
            35   33  34 1
            36   34  35 2
            37   35  36 1
            38   36  37 2
            39   32  37 1
            40   34  38 1
            41   38  39 1
            42   38  40 2
            43   39  41 1
            44   19  42 1
            45   19  43 1

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