KEGG   DRUG: トピラマート
エントリ  
D00537                      Drug                                   

一般名   
トピラマート (JAN);
Topiramate (JAN/USP/INN)
商品名   
  後発品
米国の商品 
  後発品
TOPIRAMATE (A-S Medication Solutions), TOPIRAMATE (A-S Medication Solutions), TOPIRAMATE (A-S Medication Solutions), TOPIRAMATE (A-S Medication Solutions), TOPIRAMATE (A-S Medication Solutions), TOPIRAMATE (A-S Medication Solutions), TOPIRAMATE (A-S Medication Solutions), TOPIRAMATE (American Health Packaging), TOPIRAMATE (Aphena Pharma Solutions - Tennessee), TOPIRAMATE (Aphena Pharma Solutions - Tennessee), TOPIRAMATE (Aphena Pharma Solutions - Tennessee), TOPIRAMATE (Aphena Pharma Solutions - Tennessee), TOPIRAMATE (Aphena Pharma Solutions - Tennessee), TOPIRAMATE (Aurobindo Pharma Limited), TOPIRAMATE (Bryant Ranch Prepack), TOPIRAMATE (Bryant Ranch Prepack), TOPIRAMATE (Bryant Ranch Prepack), TOPIRAMATE (Bryant Ranch Prepack), TOPIRAMATE (Bryant Ranch Prepack), TOPIRAMATE (Bryant Ranch Prepack), TOPIRAMATE (Bryant Ranch Prepack), TOPIRAMATE (Cadila Healthcare Limited), TOPIRAMATE (Cadila Healthcare Limited), TOPIRAMATE (Cadila Healthcare Limited), TOPIRAMATE (Cardinal Health), TOPIRAMATE (Cipla USA), TOPIRAMATE (Cipla USA), TOPIRAMATE (DIRECT RX), TOPIRAMATE (DIRECT RX), TOPIRAMATE (DIRECT RX), TOPIRAMATE (DIRECT RX), TOPIRAMATE (DOH CENTRAL PHARMACY), TOPIRAMATE (DOH CENTRAL PHARMACY), TOPIRAMATE (Denton Pharma), TOPIRAMATE (Denton Pharma), TOPIRAMATE (Denton Pharma), TOPIRAMATE (Denton Pharma), TOPIRAMATE (Denton Pharma), TOPIRAMATE (Denton Pharma), TOPIRAMATE (DirectRX), TOPIRAMATE (Direct_Rx), TOPIRAMATE (Direct_Rx), TOPIRAMATE (Direct_Rx), TOPIRAMATE (Direct_Rx), TOPIRAMATE (Direct_Rx), TOPIRAMATE (EXELAN PHARMACEUTICALS), TOPIRAMATE (Glenmark Pharmaceuticals), TOPIRAMATE (Golden State Medical Supply), TOPIRAMATE (Lake Erie Medical DBA Quality Care Products LLC), TOPIRAMATE (Lake Erie Medical DBA Quality Care Products LLC), TOPIRAMATE (Lake Erie Medical DBA Quality Care Products LLC), TOPIRAMATE (Lake Erie Medical DBA Quality Care Products LLC), TOPIRAMATE (Medsource Pharmaceuticals), TOPIRAMATE (NCS HealthCare of KY), TOPIRAMATE (Northwind Pharmaceuticals), TOPIRAMATE (NuCare Pharmaceuticals), TOPIRAMATE (NuCare Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (PD-Rx Pharmaceuticals), TOPIRAMATE (Preferred Pharmaceuticals), TOPIRAMATE (Preferred Pharmaceuticals), TOPIRAMATE (Preferred Pharmaceuticals), TOPIRAMATE (Preferred Pharmaceuticals), TOPIRAMATE (Preferred Pharmaceuticals), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Proficient Rx LP), TOPIRAMATE (Quality Care Products), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (REMEDYREPACK), TOPIRAMATE (St. Mary's Medical Park Pharmacy), TOPIRAMATE (St. Mary's Medical Park Pharmacy), TOPIRAMATE (St. Mary's Medical Park Pharmacy), TOPIRAMATE (St. Mary's Medical Park Pharmacy), TOPIRAMATE (Sun Pharmaceutical Industries), TOPIRAMATE (Sun Pharmaceutical Industries), TOPIRAMATE (Teva Pharmaceuticals USA), TOPIRAMATE (Unichem Pharmaceuticals (USA)), TOPIRAMATE (Upsher-Smith Laboratories), TOPIRAMATE (Zydus Pharmaceuticals (USA)), TOPIRAMATE (Zydus Pharmaceuticals (USA)), TOPIRAMATE (Zydus Pharmaceuticals (USA)), TOPIRAMATE (medsource pharmaceuticals), TOPIRAMATE (medsource pharmaceuticals), TOPAMAX (Advanced Rx Pharmacy of Tennessee)
組成式   
C12H21NO8S
質量    
339.0988
分子量   
339.362
構造式   
Simcomp   
クラス   
精神神経系用薬
 DG01569  AMPA受容体拮抗薬
その他
 DG01575  カルシウムチャネル遮断薬
  DG01496  カルシウムチャネルL型遮断薬
代謝酵素基質薬
 DG02913  CYP3A4基質薬
コード   
同一コード: C07502
薬効分類: 1139
ATCコード: N03AX11
商品: D00537<JP/US>
商品 (mixture): D11710<US>
効能    
抗けいれん薬, 抗てんかん薬, AMPA受容体拮抗薬
コメント  
GABA存在下におけるGABAA受容体機能増強作用 (クロライドイオン流入促進)
ターゲット 
GRIA [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200]
GRIK [HSA:2897 2898 2899 2900 2901] [KO:K05201 K05202 K05203 K05204 K05205]
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
CA2 [HSA:760] [KO:K18245]
CA4 [HSA:762] [KO:K18246]
  パスウェイ
hsa04020  カルシウムシグナル伝達経路
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04724  グルタミン酸作動性シナプス
hsa04727  GABA作動性シナプス
代謝    
Enzyme: CYP3A4 [HSA:1576]
相互作用  

構造マップ 
map07033  抗痙攣薬
map07231  ナトリウムチャネル遮断薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   113  抗てんかん剤
    1139  その他の抗てんかん剤
     D00537  トピラマート (JAN)
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N03 抗てんかん薬
   N03A 抗てんかん薬
    N03AX その他の抗てんかん薬
     N03AX11 トピラマート
      D00537  トピラマート (JAN) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 抗けいれん薬
  抗けいれん薬, その他
   マルチプルMOA
    トピラマート
     D00537  トピラマート (JAN)
 抗片頭痛薬
  予防薬
   トピラマート
    D00537  トピラマート (JAN)
ターゲットに基づく医薬品分類 [BR:jp08310]
 イオンチャネル
  リガンド依存性イオンチャネル
   GABA (イオンチャネル型)
    GABR
     D00537  トピラマート (JAN) <JP/US>
   グルタミン酸 (イオンチャネル型), non-NMDA
    GRIA
     D00537  トピラマート (JAN) <JP/US>
    GRIK
     D00537  トピラマート (JAN) <JP/US>
  電位依存性イオンチャネル
   ナトリウムチャネル
    SCN1A
     D00537  トピラマート (JAN) <JP/US>
    SCN2A
     D00537  トピラマート (JAN) <JP/US>
    SCN3A
     D00537  トピラマート (JAN) <JP/US>
    SCN4A
     D00537  トピラマート (JAN) <JP/US>
    SCN5A
     D00537  トピラマート (JAN) <JP/US>
    SCN8A
     D00537  トピラマート (JAN) <JP/US>
    SCN9A
     D00537  トピラマート (JAN) <JP/US>
    SCN10A
     D00537  トピラマート (JAN) <JP/US>
    SCN11A
     D00537  トピラマート (JAN) <JP/US>
   カルシウムチャネル
    CACNA1-L
     D00537  トピラマート (JAN) <JP/US>
 酵素
  リアーゼ (EC4)
   アルデヒドリアーゼ
    CA2
     D00537  トピラマート (JAN) <JP/US>
    CA4
     D00537  トピラマート (JAN) <JP/US>
日本の新薬 [jp08318.html]
 新有効成分含有医薬品
  D00537
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00537
リンク   
CAS: 97240-79-4
PubChem: 7847603
ChEBI: 63631
ChEMBL: CHEMBL220492
DrugBank: DB00273
PDB-CCD: TOR[PDBj]
LigandBox: D00537
日化辞: J345.989F
LinkDB    

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