KEGG   ORTHOLOGY: K05093
Entry
K05093                      KO                                     

Name
FGFR2, CD332
Definition
fibroblast growth factor receptor 2 [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05215  Prostate cancer
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00458  Syndromic craniosynostoses
H00642  Lacrimo-auriculo-dento-digital syndrome
H01753  Antley-Bixler syndrome
H01754  Crouzon syndrome
H01755  Apert syndrome
H01756  Pfeiffer syndrome
H01988  Jackson-Weiss syndrome
H01989  Beare-Stevenson syndrome
H01991  Saethre-Chotzen syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04015 Rap1 signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04010 MAPK signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04151 PI3K-Akt signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05230 Central carbon metabolism in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09162 Cancer: specific types
   05226 Gastric cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05215 Prostate cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   00536 Glycosaminoglycan binding proteins
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
CD molecules [BR:ko04090]
 Proteins
  K05093  CD332, FGFR2; fibroblast growth factor receptor 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Growth factors/receptors
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Other DBs
GO: 0005007
Genes
HSA: 2263(FGFR2)
PTR: 466220(FGFR2)
PPS: 100981139(FGFR2)
GGO: 101153046(FGFR2)
PON: 100171540(FGFR2)
NLE: 100598157(FGFR2)
MCC: 715949(FGFR2)
MCF: 102143086(FGFR2)
CSAB: 103216628(FGFR2)
RRO: 104675847(FGFR2)
RBB: 108529768(FGFR2)
CJC: 100393573(FGFR2)
SBQ: 101033845(FGFR2)
MMU: 14183(Fgfr2)
MCAL: 110299396(Fgfr2)
MPAH: 110326449(Fgfr2)
RNO: 25022(Fgfr2)
MUN: 110554946(Fgfr2)
CGE: 100763455(Fgfr2)
NGI: 103729272(Fgfr2)
HGL: 101709077(Fgfr2)
CCAN: 109691649(Fgfr2)
OCU: 100009417(FGFR2)
TUP: 102484403(FGFR2)
CFA: 415125(FGFR2)
VVP: 112916723(FGFR2)
AML: 100468267(FGFR2)
UMR: 103657802(FGFR2)
UAH: 113252011(FGFR2)
ORO: 101381278(FGFR2)
FCA: 101095198(FGFR2)
PTG: 102964142(FGFR2)
PPAD: 109272992(FGFR2)
AJU: 106969379(FGFR2)
BTA: 404193(FGFR2)
BOM: 102270743(FGFR2)
BIU: 109553142(FGFR2)
BBUB: 102402932(FGFR2)
CHX: 102170938(FGFR2)
OAS: 443548(FGFR2)
SSC: 396762(FGFR2)
CFR: 102516073(FGFR2)
CDK: 105104060(FGFR2)
BACU: 103012184(FGFR2)
LVE: 103090812(FGFR2)
OOR: 101272068(FGFR2)
DLE: 111172240(FGFR2)
PCAD: 102982044(FGFR2)
ECB: 100033956(FGFR2)
EPZ: 103547114(FGFR2)
EAI: 106846935(FGFR2)
MYB: 102254053(FGFR2)
MYD: 102763283(FGFR2)
MNA: 107532684(FGFR2)
HAI: 109383003(FGFR2)
DRO: 112300272(FGFR2)
PALE: 102882899(FGFR2)
RAY: 107512997(FGFR2)
MJV: 108395520(FGFR2)
LAV: 100664128
TMU: 101357035
MDO: 100025727(FGFR2)
SHR: 100932215(FGFR2)
PCW: 110209582(FGFR2)
OAA: 100084641(FGFR2)
GGA: 396259(FGFR2)
MGP: 100540905(FGFR2)
CJO: 107316195(FGFR2)
NMEL: 110399304(FGFR2)
APLA: 101791540(FGFR2)
ACYG: 106038987(FGFR2)
TGU: 100223379(FGFR2)
LSR: 110469999(FGFR2)
SCAN: 103813785(FGFR2)
GFR: 102038840(FGFR2)
FAB: 101812169(FGFR2)
PHI: 102105117(FGFR2)
PMAJ: 107206911(FGFR2)
CCAE: 111931374(FGFR2)
CCW: 104694675(FGFR2)
ETL: 114065192(FGFR2)
FPG: 101913692(FGFR2)
FCH: 102056102(FGFR2)
CLV: 102091137(FGFR2)
EGZ: 104123669(FGFR2)
NNI: 104020574(FGFR2)
ACUN: 113481500(FGFR2)
PADL: 103918542(FGFR2)
AAM: 106499024(FGFR2)
ASN: 102382394(FGFR2)
AMJ: 102564591(FGFR2)
PSS: 102443772(FGFR2)
CMY: 102938554(FGFR2)
CPIC: 101933273(FGFR2)
ACS: 100562611(fgfr2)
PVT: 110075320(FGFR2)
PBI: 103057830(FGFR2)
PMUR: 107288600(FGFR2)
TSR: 106554429
PMUA: 114597424(FGFR2)
GJA: 107112647(FGFR2)
XLA: 108697372(fgfr2.S) 399325(fgfr2.L)
XTR: 100124910(fgfr2)
NPR: 108793050(FGFR2)
DRE: 352940(fgfr2)
SANH: 107655670 107679170(fgfr2)
SGH: 107585454 107597642(fgfr2)
CCAR: 109068396 109100701(fgfr2)
IPU: 108263349(fgfr2) 108276549
PHYP: 113542009(fgfr2)
AMEX: 103024961
EEE: 113588015(fgfr2)
TRU: 101073665(fgfr2) 105418712
LCO: 104925607(fgfr2)
NCC: 104962476
MZE: 101463957(fgfr2)
ONL: 100699731(fgfr2)
OLA: 100049483(fgfr2) 101174210
XMA: 102233809
XCO: 114138295
PRET: 103477293
CVG: 107081753(fgfr2)
NFU: 107375397(fgfr2)
KMR: 108240654(fgfr2)
ALIM: 106526530(fgfr2)
AOCE: 111571792(fgfr2)
CSEM: 103391367
LCF: 108885762(fgfr2) 108900295
SDU: 111220545(fgfr2)
SLAL: 111658940(fgfr2)
HCQ: 109523130(fgfr2)
BPEC: 110168143(fgfr2)
MALB: 109959332(fgfr2)
ELS: 105010630(fgfr2)
SFM: 108925828(fgfr2)
PKI: 111839944(fgfr2)
LCM: 102349925(FGFR2)
CMK: 103185425(fgfr2)
RTP: 109910693(fgfr2)
SPU: 115917872
DME: Dmel_CG32134(btl)
DER: 6545596
DSE: 6605643
DSI: Dsimw501_GD14480(Dsim_GD14480)
DSR: 110190281
DPE: 113565986
DMN: 108152297
DWI: 6639356
DAZ: 108612213
DNV: 108651226
DHE: 111600927
MDE: 101901067
LCQ: 111675215
AME: 413200
BIM: 100747636
BTER: 100643345
CCAL: 108632478
OBB: 114878227
SOC: 105196299
MPHA: 105830905
AEC: 105147047
ACEP: 105624923
VEM: 105565532
DQU: 106748031
CFO: 105249959
LHU: 105679827
OBO: 105278054
PCF: 106786979
MDL: 103569982
TCA: 659434(DFR1)
NVL: 108565311
PMAC: 106715481
RMD: 113554812
BTAB: 109038511
CLEC: 106661466
ZNE: 110826648
FCD: 110841674
TUT: 107364957
DPTE: 113797385
PTEP: 107438841
MYI: 110455387
OBI: 106868677
LAK: 106166604
SHX: MS3_01300
DGT: 114526313
AQU: 100633582
 » show all
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
DOI:10.1002/j.1460-2075.1990.tb07454.x
  Sequence
[hsa:2263]
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