KEGG   PATHWAY: apla04914
Entry
apla04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Anas platyrhynchos (mallard)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
apla04914  Progesterone-mediated oocyte maturation
apla04914

Other DBs
GO: 0001556
Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101797573  PGR; progesterone receptor isoform X1 [KO:K08556]
101803461  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101799717  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101795759  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101796183  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101800900  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101802796  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101799011  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
101793594  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106014314  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101802116  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101805023  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
101792057  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101793591  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101797591  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
101803759  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
101798529  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101804073  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101803512  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101791112  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101794067  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
119715289  ADCY6; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101794076  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101794043  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101800617  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
101791856  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
101795813  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
101792042  CPEB1; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 1 [KO:K02602]
101797288  CPEB3; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
101802778  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
101801772  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
101798426  SPDYA; speedy protein A [KO:K08694]
101803686  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101803433  CCNA1; cyclin-A1 [KO:K06627]
101792368  CCNA2; cyclin-A2 [KO:K06627]
101804433  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
101800442  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101791037  MAP2K1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101800319  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101792994  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
101798660  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
101797651  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
101800942  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101792974  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101804825  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
101797452  STK10; LOW QUALITY PROTEIN: serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
101800116  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
101800901  CDC25A; LOW QUALITY PROTEIN: M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
101794427  INS; insulin [KO:K04526]
101793597  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101802018  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101804556  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101800458  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101798259  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
101793538  KRAS; GTPase KRas isoform X1 [KO:K07827]
101794380  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101795633  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101803695  BUB1; LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
101798731  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
101803773  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
101789847  FZR1; fizzy-related protein homolog [KO:K03364]
101800170  ANAPC1; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1 [KO:K03348]
101795680  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
101799574  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
101805070  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
101801474  ANAPC5; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5 [KO:K03352]
101796312  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
101805452  ANAPC7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
101799308  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101793820  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
119713137  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
113845436  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
101792825  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
101790372  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
apla04010  MAPK signaling pathway
apla04110  Cell cycle
KO pathway
ko04914   
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