KEGG   PATHWAY: ko04914
Entry
ko04914                     Pathway                                
Name
Progesterone-mediated oocyte maturation
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
ko04914  Progesterone-mediated oocyte maturation
ko04914

Drug
D02840  Altrenogest (USAN/INN)
Other DBs
GO: 0001556
Orthology
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02087  CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K02178  BUB1; checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K02537  MAD2; mitotic spindle assembly checkpoint protein MAD2
K02602  CPEB, ORB; cytoplasmic polyadenylation element-binding protein
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K03348  APC1, ANAPC1; anaphase-promoting complex subunit 1
K03349  APC2, ANAPC2; anaphase-promoting complex subunit 2
K03350  APC3, CDC27; anaphase-promoting complex subunit 3
K03351  APC4, ANAPC4; anaphase-promoting complex subunit 4
K03352  APC5, ANAPC5; anaphase-promoting complex subunit 5
K03353  APC6, CDC16; anaphase-promoting complex subunit 6
K03354  APC7, ANAPC7; anaphase-promoting complex subunit 7
K03355  APC8, CDC23; anaphase-promoting complex subunit 8
K03357  APC10, ANAPC10, DOC1; anaphase-promoting complex subunit 10
K03358  APC11, ANAPC11; anaphase-promoting complex subunit 11
K03359  APC12, CDC26; anaphase-promoting complex subunit 12
K03364  CDH1, FZR1; cell division cycle 20-like protein 1, cofactor of APC complex
K04079  HSP90A, htpG; molecular chaperone HtpG
K04345  PKA; protein kinase A [EC:2.7.11.11]
K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04367  MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04373  RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04441  P38; p38 MAP kinase [EC:2.7.11.24]
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04526  INS; insulin
K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05459  IGF1; insulin-like growth factor 1
K05866  CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
K05867  CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
K05868  CCNB1; G2/mitotic-specific cyclin-B1
K06627  CCNA; cyclin-A
K06631  PLK1; polo-like kinase 1 [EC:2.7.11.21]
K06633  PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
K06645  CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
K06679  MAD1; mitotic spindle assembly checkpoint protein MAD1
K07827  KRAS, KRAS2; GTPase KRas
K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K08556  PGR, NR3C3; progesterone receptor
K08694  SPDY, RINGO; speedy
K08837  STK10, LOK; serine/threonine kinase 10 [EC:2.7.11.1]
K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K10403  KIF22; kinesin family member 22
K11481  AURKA; aurora kinase A [EC:2.7.11.1]
K12456  APC13, ANAPC13; anaphase-promoting complex subunit 13
K13296  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17]
K13728  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B
K21770  CCNB2; G2/mitotic-specific cyclin-B2
K21771  CCNB3; G2/mitotic-specific cyclin-B3
K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
K25229  APC16, ANAPC16; anaphase-promoting complex subunit 16
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
ko04010  MAPK signaling pathway
ko04110  Cell cycle

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