KEGG   PATHWAY: vga00260
Entry
vga00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Vibrio gazogenes
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vga00260  Glycine, serine and threonine metabolism
vga00260

Module
vga_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vga00260]
vga_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vga00260]
vga_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:vga00260]
vga_M00555  Betaine biosynthesis, choline => betaine [PATH:vga00260]
vga_M00621  Glycine cleavage system [PATH:vga00260]
vga_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:vga00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Vibrio gazogenes [GN:vga]
Gene
BSQ33_05540  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSQ33_20860  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSQ33_06795  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BSQ33_05150  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BSQ33_10105  metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BSQ33_03990  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSQ33_14150  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSQ33_05145  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BSQ33_05140  threonine synthase [KO:K01733] [EC:4.2.3.1]
BSQ33_01920  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSQ33_13570  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSQ33_06800  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BSQ33_11045  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BSQ33_18060  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BSQ33_07215  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BSQ33_11235  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSQ33_20185  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSQ33_17290  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSQ33_15680  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BSQ33_00605  hypothetical protein [KO:K01079] [EC:3.1.3.3]
BSQ33_05075  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BSQ33_16925  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BSQ33_16930  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BSQ33_16515  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BSQ33_16530  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BSQ33_11580  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSQ33_16520  glycine cleavage system protein H [KO:K02437]
BSQ33_07335  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
BSQ33_08615  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BSQ33_08610  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSQ33_01560  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
BSQ33_01555  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
BSQ33_01865  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
BSQ33_01860  (Fe-S)-binding protein [KO:K21834]
BSQ33_01855  electron transfer flavoprotein subunit alpha [KO:K25960]
BSQ33_01850  electron transfer flavoprotein subunit beta [KO:K25961]
BSQ33_01905  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BSQ33_01915  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BSQ33_01900  hypothetical protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BSQ33_01910  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BSQ33_01545  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BSQ33_01890  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BSQ33_09055  threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BSQ33_03750  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BSQ33_20190  aspartate racemase [KO:K25316] [EC:5.1.1.10]
BSQ33_15755  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BSQ33_15760  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BSQ33_00495  aminotransferase class III [KO:K00836] [EC:2.6.1.76]
BSQ33_20850  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BSQ33_20845  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
BSQ33_20855  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vga00010  Glycolysis / Gluconeogenesis
vga00020  Citrate cycle (TCA cycle)
vga00230  Purine metabolism
vga00250  Alanine, aspartate and glutamate metabolism
vga00270  Cysteine and methionine metabolism
vga00290  Valine, leucine and isoleucine biosynthesis
vga00300  Lysine biosynthesis
vga00330  Arginine and proline metabolism
vga00460  Cyanoamino acid metabolism
vga00470  D-Amino acid metabolism
vga00564  Glycerophospholipid metabolism
vga00600  Sphingolipid metabolism
vga00620  Pyruvate metabolism
vga00630  Glyoxylate and dicarboxylate metabolism
vga00640  Propanoate metabolism
vga00680  Methane metabolism
vga00860  Porphyrin metabolism
vga00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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