KEGG   DRUG: Sunitinib malate
Entry
D06402                      Drug                                   

Name
Sunitinib malate (JAN/USAN);
Sutent (TN)
Product
  Generic
Formula
C22H27FN4O2. C4H6O5
Exact mass
532.2333
Mol weight
532.5612
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 4291
ATC code: L01EX01
Chemical structure group: DG00712
Product (DG00712): D06402<JP/US>
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
  Disease
Gastrotintestinal stromal tumor [DS:H01591]
Renal cell carcinoma [DS:H00021]
Pancreatic neuroendocrine tumor [DS:H00045]
Target
CSF1 [HSA:1435] [KO:K05453]
FLT3 (CD135) [HSA:2322] [KO:K05092]
PDGFR [HSA:5156 5159] [KO:K04363 K05089]
RET [HSA:5979] [KO:K05126]
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07045  Antineoplastics - protein kinase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX01 Sunitinib
      D06402  Sunitinib malate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Sunitinib
    D06402  Sunitinib malate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06402  Sunitinib malate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFR
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    KIT (CD117)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    FLT3 (CD135)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
   VEGFR family
    VEGFR1 (FLT1)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    VEGFR2 (KDR)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    VEGFR3 (FLT4)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
   RET family
    RET
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
 Cytokines and receptors
  Cytokines
   CSF and other factors
    CSF1
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06402
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06402
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06402
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06402
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D06402
Other DBs
CAS: 341031-54-7
PubChem: 47208059
ChEMBL: CHEMBL1567
DrugBank: DB01268
LigandBox: D06402
NIKKAJI: J2.374.908D
LinkDB
KCF data

ATOM        38
            1   C8x C    41.1025  -27.7475
            2   C8x C    39.9075  -28.4505
            3   C8y C    39.9075  -29.8564
            4   C8x C    41.1025  -30.5593
            5   C8y C    42.2975  -29.8564
            6   C8y C    42.2975  -28.4505
            7   C2y C    43.7033  -30.2781
            8   C5x C    44.4766  -29.1535
            9   N1x N    43.7033  -28.0288
            10  X   F    38.7126  -30.5593
            11  O5x O    45.8824  -29.1535
            12  C2b C    43.7033  -31.6839
            13  C8y C    44.8983  -32.3869
            14  C8y C    44.8983  -33.7928
            15  C8y C    46.2339  -34.2145
            16  C8y C    47.0071  -33.0899
            17  N4x N    46.2339  -31.9652
            18  C1a C    43.7033  -34.6362
            19  C1a C    48.4130  -33.0899
            20  C5a C    46.2339  -35.6203
            21  O5a O    45.0165  -36.3233
            22  N1b N    47.4514  -36.3233
            23  C1b C    48.6519  -35.6301
            24  C1b C    49.8443  -36.3184
            25  N1c N    51.0404  -35.6276
            26  C1b C    52.2349  -36.3171
            27  C1a C    53.4300  -35.6270
            28  C1b C    51.0404  -34.2148
            29  C1a C    52.2379  -33.5231
            30  C1c C    51.9013  -29.3983
            31  C1b C    53.1022  -30.0910
            32  C6a C    50.7070  -30.0910
            33  O1a O    51.9013  -28.0135
            34  C6a C    54.2965  -29.3983
            35  O6a O    49.5126  -29.3921
            36  O6a O    50.7132  -31.6079
            37  O6a O    55.4909  -30.0910
            38  O6a O    54.2902  -28.0135
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12    8  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   14  18 1
            21   16  19 1
            22   15  20 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   25  28 1
            31   28  29 1
            32   30  31 1
            33   30  32 1
            34   30  33 1 #Up
            35   31  34 1
            36   32  35 1
            37   32  36 2
            38   34  37 1
            39   34  38 2

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