KEGG   DRUG: Sunitinib malate
Entry
D06402                      Drug                                   
Name
Sunitinib malate (JAN/USAN);
Sutent (TN)
Product
SUTENT (Pfizer Laboratories Div Pfizer), SUTENT (U.S. Pharmaceuticals)
  Generic
SUNITINIB MALATE (Aurobindo Pharma Limited), SUNITINIB MALATE (AvKARE), SUNITINIB MALATE (Dr.Reddys Laboratories), SUNITINIB MALATE (Mylan Pharmaceuticals), SUNITINIB MALATE (NorthStar RxLLC), SUNITINIB MALATE (Novugen Pharma (USA) LLC.), SUNITINIB MALATE (Sun Pharmaceutical Industries), SUNITINIB MALATE (Teva Pharmaceuticals USA)
Formula
C22H27FN4O2. C4H6O5
Exact mass
532.2333
Mol weight
532.56
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 4291
ATC code: L01EX01
Chemical structure group: DG00712
Product (DG00712): D06402<JP/US>
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
  Disease
Gastrotintestinal stromal tumor [DS:H01591]
Renal cell carcinoma [DS:H00021]
Pancreatic neuroendocrine tumor [DS:H00045]
Target
CSF1R (FMS, CD115) [HSA:1436] [KO:K05090]
FLT3 (CD135) [HSA:2322] [KO:K05092]
PDGFR [HSA:5156 5159] [KO:K04363 K05089]
RET [HSA:5979] [KO:K05126]
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07045  Antineoplastics - protein kinase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX01 Sunitinib
      D06402  Sunitinib malate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Multitargeted Kinase Inhibitors
    Sunitinib
     D06402  Sunitinib malate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06402  Sunitinib malate (JAN/USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG00712  Sunitinib
     D06402  Sunitinib malate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00712  Sunitinib
     D06402  Sunitinib malate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFR
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    KIT (CD117)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    FLT3 (CD135)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
   VEGFR family
    VEGFR1 (FLT1)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    VEGFR2 (KDR)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
    VEGFR3 (FLT4)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
   RET family
    RET
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF1R (FMS, CD115)
     D06402  Sunitinib malate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06402
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06402
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06402
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06402
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D06402
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG00712  Sunitinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00712  Sunitinib
Other DBs
CAS: 341031-54-7
PubChem: 47208059
ChEBI: 232546
LigandBox: D06402
NIKKAJI: J2.374.908D
LinkDB
KCF data

ATOM        38
            1   C8x C    41.1025  -27.7475
            2   C8x C    39.9075  -28.4505
            3   C8y C    39.9075  -29.8564
            4   C8x C    41.1025  -30.5593
            5   C8y C    42.2975  -29.8564
            6   C8y C    42.2975  -28.4505
            7   C2y C    43.7033  -30.2781
            8   C5x C    44.4766  -29.1535
            9   N1x N    43.7033  -28.0288
            10  X   F    38.7126  -30.5593
            11  O5x O    45.8824  -29.1535
            12  C2b C    43.7033  -31.6839
            13  C8y C    44.8983  -32.3869
            14  C8y C    44.8983  -33.7928
            15  C8y C    46.2339  -34.2145
            16  C8y C    47.0071  -33.0899
            17  N4x N    46.2339  -31.9652
            18  C1a C    43.7033  -34.6362
            19  C1a C    48.4130  -33.0899
            20  C5a C    46.2339  -35.6203
            21  O5a O    45.0165  -36.3233
            22  N1b N    47.4514  -36.3233
            23  C1b C    48.6519  -35.6301
            24  C1b C    49.8443  -36.3184
            25  N1c N    51.0404  -35.6276
            26  C1b C    52.2349  -36.3171
            27  C1a C    53.4300  -35.6270
            28  C1b C    51.0404  -34.2148
            29  C1a C    52.2379  -33.5231
            30  C1c C    51.9013  -29.3983
            31  C1b C    53.1022  -30.0910
            32  C6a C    50.7070  -30.0910
            33  O1a O    51.9013  -28.0135
            34  C6a C    54.2965  -29.3983
            35  O6a O    49.5126  -29.3921
            36  O6a O    50.7132  -31.6079
            37  O6a O    55.4909  -30.0910
            38  O6a O    54.2902  -28.0135
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12    8  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   14  18 1
            21   16  19 1
            22   15  20 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   25  28 1
            31   28  29 1
            32   30  31 1
            33   30  32 1
            34   30  33 1 #Up
            35   31  34 1
            36   32  35 1
            37   32  36 2
            38   34  37 1
            39   34  38 2

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