KEGG   ORTHOLOGY: K05119
Entry
K05119                      KO                                     
Symbol
ALK, CD246
Name
anaplastic lymphoma kinase [EC:2.7.10.1]
Pathway
map05200  Pathways in cancer
map05223  Non-small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00014  Non-small cell lung cancer
H00043  Neuroblastoma
H01601  Anaplastic large-cell lymphoma
H01892  Peripheral T cell lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05119  ALK, CD246; anaplastic lymphoma kinase
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05119  ALK, CD246; anaplastic lymphoma kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05119  ALK, CD246; anaplastic lymphoma kinase
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  ALK family
   K05119  ALK, CD246; anaplastic lymphoma kinase
CD molecules [BR:ko04090]
 Proteins
  K05119  CD246, ALK; anaplastic lymphoma kinase (Ki-1)
Genes
HSA: 238(ALK)
PTR: 459127(ALK)
PPS: 100981152(ALK)
GGO: 101141580(ALK)
PON: 100458012(ALK)
NLE: 100593886(ALK)
MCC: 704823(ALK)
MCF: 102128455(ALK)
MTHB: 126933845
CSAB: 103220559(ALK)
CATY: 105578422(ALK)
PANU: 101020267(ALK)
TGE: 112604482(ALK)
RRO: 104663931(ALK)
RBB: 108532772(ALK)
TFN: 117062859(ALK)
PTEH: 111546025(ALK)
CJC: 100399252(ALK)
SBQ: 101044905(ALK)
CSYR: 103258328(ALK)
MMUR: 105884443(ALK)
LCAT: 123636762(ALK)
OGA: 100962152(ALK)
MMU: 11682(Alk)
MCAL: 110312131(Alk)
MPAH: 110335467(Alk)
RNO: 266802(Alk)
MCOC: 116080916(Alk)
MUN: 110554521(Alk)
CGE: 100760366(Alk)
MAUA: 101826367(Alk)
PLEU: 114696211
MORG: 121432787(Alk)
MFOT: 126514228
AAMP: 119807820(Alk)
NGI: 103744649(Alk)
HGL: 101703312(Alk)
CCAN: 109679287(Alk)
DORD: 105983615(Alk)
DSP: 122122452(Alk)
OCU: 100347722(ALK)
OPI: 101523838(ALK)
TUP: 102492665(ALK)
CFA: 483021(ALK)
CLUD: 112664584(ALK)
VVP: 112932997(ALK)
VLG: 121491291(ALK)
AML: 100473389(ALK)
UMR: 103671905(ALK)
UAH: 113268019(ALK)
UAR: 123799871(ALK)
ELK: 111139287
LLV: 125108900
MPUF: 101675512(ALK)
ORO: 101373502(ALK)
EJU: 114205969(ALK)
ZCA: 113937534(ALK)
MLX: 118007728(ALK)
NSU: 110587472(ALK)
FCA: 101091689(ALK)
PYU: 121044299(ALK)
LRUF: 124503580
PTG: 102970257(ALK)
PPAD: 109266408(ALK)
AJU: 106967924(ALK)
HHV: 120235917(ALK)
BTA: 536642(ALK)
BOM: 106701242(ALK)
BIU: 109565582(ALK)
BBUB: 102394478(ALK)
CHX: 106502631(ALK)
OAS: 101114094(ALK)
ODA: 120852278(ALK)
CCAD: 122441873(ALK)
SSC: 100518423(ALK)
CFR: 102504436(ALK)
CBAI: 105063892(ALK)
CDK: 105098577(ALK)
VPC: 102530047(ALK)
BACU: 103020848(ALK)
LVE: 103082654(ALK)
OOR: 101281727(ALK)
DLE: 111174732(ALK)
PCAD: 102988118(ALK)
PSIU: 116764566(ALK)
ECB: 100070891
EPZ: 103549200(ALK)
EAI: 106837084(ALK)
MYB: 102242645(ALK) 102263072
MYD: 102759675(ALK)
MMYO: 118669138
MLF: 102423499(ALK)
MNA: 107534860(ALK)
PKL: 118717153(ALK)
HAI: 109390951(ALK)
DRO: 112298036(ALK)
SHON: 119001399
AJM: 119050428(ALK)
PDIC: 114498728(ALK)
PHAS: 123822548(ALK)
MMF: 118630477(ALK)
PALE: 102884662(ALK)
PGIG: 120621811(ALK)
PVP: 105299153(ALK)
RAY: 107511136(ALK)
MJV: 108408692(ALK)
TOD: 119259431(ALK)
SARA: 101552411(ALK)
LAV: 100661350(ALK)
TMU: 101346489
DNM: 101436525(ALK)
MDO: 100031373(ALK)
SHR: 100931895(ALK)
PCW: 110206438(ALK)
OAA: 100078902(ALK)
GGA: 421297(ALK) 423216(LTK)
PCOC: 116228995(LTK) 116232882(ALK)
MGP: 100542012(LTK) 100543352(ALK)
CJO: 107310876(ALK) 107314725(LTK)
NMEL: 110396255(ALK) 110402026(LTK)
APLA: 101789875(LTK) 101797885(ALK)
ACYG: 106043115(LTK) 106043136(ALK)
AFUL: 116487399(ALK) 116489565(LTK)
TGU: 100221054(LTK) 100221929(ALK)
LSR: 110472103(LTK) 110472832(ALK)
SCAN: 103821381(ALK) 103826985(LTK)
PMOA: 120500240(LTK) 120501437(ALK)
OTC: 121335218(LTK) 121346359(ALK)
PRUF: 121349544(LTK) 121365305(ALK)
GFR: 102034482(ALK) 102036797(LTK)
FAB: 101817862(LTK) 101819549(ALK)
PHI: 102108510(LTK) 102112738(ALK)
PMAJ: 107202471(ALK) 107205794(LTK)
CCAE: 111926304(ALK) 111930075(LTK)
CCW: 104685582(ALK) 104698444(LTK)
CBRC: 103612847(ALK) 103620942(LTK)
ETL: 114059427(LTK) 114060910(ALK)
ZAB: 102062928(LTK) 102067281(ALK)
ACHL: 103797047 103809189(ALK)
FPG: 101923162(LTK) 101924804(ALK)
FCH: 102055199(LTK) 102059446(ALK)
CLV: 102096456 102097986(LTK)
EGZ: 104127545(LTK) 104134596(ALK)
NNI: 104018112(ALK) 104020450(LTK)
PLET: 104621176(LTK) 104626083(ALK)
PCRI: 104028199
ACUN: 113478473(ALK) 113480533(LTK)
TALA: 104367156(ALK) 104367766(LTK)
PADL: 103912815(LTK) 103925041(ALK)
AFOR: 103897557(LTK) 103904197(ALK)
ACHC: 115350029(ALK) 115351322(LTK)
HALD: 104319193(ALK) 104325267
CCRI: 104161131(ALK) 104162458
CSTI: 104560888(ALK)
EHS: 104514521(LTK) 104514751(ALK)
CMAC: 104481273(LTK)
MUI: 104536379 104542420(ALK)
FGA: 104074297(ALK) 104078139
LDI: 104345034(ALK) 104352590(LTK)
MNB: 103780963(ALK) 103781719
OHA: 104328172(LTK) 104331983(ALK)
NNT: 104405106(ALK) 104412431(LTK)
DPUB: 104305202(ALK) 104309447(LTK)
PGUU: 104460144
ACAR: 104526896 104531762(ALK)
AVIT: 104272140
CVF: 104283760(ALK) 104295909(LTK)
AAM: 106490437(ALK) 106498243(LTK)
AROW: 112974942(ALK) 112978010(LTK)
NPD: 112942509(LTK) 112954843(ALK)
TGT: 104565033(ALK) 104571753(LTK)
DNE: 112980009(ALK) 112980731(LTK)
SCAM: 104150395(LTK) 104153978(ALK)
ASN: 102383997(ALK) 102386513(LTK)
AMJ: 102572248(LTK) 102573864(ALK)
CPOO: 109321559(LTK)
GGN: 109298771(LTK) 109304773(ALK)
PSS: 102449858(LTK) 102462403(ALK)
CMY: 102930622(LTK) 102944568(ALK)
CPIC: 101947911(ALK) 101951471(LTK)
TST: 117876764(LTK)
CABI: 116821530(ALK) 116832818(LTK)
MRV: 120400908(ALK) 120403374(LTK)
ACS: 100553426(alk) 100563969(ltk)
PVT: 110078686(ALK) 110079037(LTK)
SUND: 121919119(LTK) 121919379
PBI: 103054608 103060733(ALK)
PMUR: 107295457 107296234(ALK)
CTIG: 120299263(LTK) 120305339(ALK)
TSR: 106538234(ALK) 106547951 106548203(LTK)
PGUT: 117665657(LTK)
VKO: 123026657(LTK) 123027693(ALK)
PMUA: 114594117(LTK) 114594587(ALK)
ZVI: 118082689(ALK) 118083387(LTK)
GJA: 107113542(ALK) 107126012(LTK)
STOW: 125426066(LTK) 125440925(ALK)
XTR: 100495071(alk) 100498306(ltk)
NPR: 108789911(LTK) 108796594(ALK)
RTEM: 120920055(LTK) 120938125(ALK)
BBUF: 120982257(LTK) 120999363(ALK)
BGAR: 122921818(LTK) 122935549
DRE: 563509(alk) 564470(ltk)
PPRM: 120475338(alk) 120477143(ltk)
MAMB: 125268925(ltk) 125268932(alk)
IPU: 108270425(alk) 108270462(ltk)
PHYP: 113539006(ltk) 113545033(alk)
SMEO: 124389853(ltk) 124389977(alk)
TFD: 113659736(alk) 113659825(ltk)
TRU: 101062160(ltk) 101068218(alk)
LCO: 104922171 104924780(alk)
NCC: 104960379
CGOB: 115027095(alk) 115027869(ltk)
ELY: 117267139(ltk) 117267295(alk)
EFO: 125900619(ltk) 125901256(alk)
PLEP: 121953617(alk) 121953763(ltk)
SLUC: 116035460(ltk) 116065689(alk)
ECRA: 117935307(alk) 117936016(ltk)
ESP: 116669879(alk) 116670035(ltk)
PFLV: 114546395 114547086(alk)
GAT: 120832647 120832824(ltk)
PPUG: 119227483 119227937(ltk)
MSAM: 119910352(ltk) 119910649(alk)
CUD: 121526218(ltk) 121526306(alk)
ALAT: 119004505(ltk) 119005175(alk)
MZE: 101473442(alk) 101473463
ONL: 100690943 100710577(alk)
OAU: 116333990(alk) 116334846(ltk)
OLA: 101156784 105357017(alk)
OML: 112143491(alk) 112149758(ltk)
XMA: 102218265(alk) 102223978
XCO: 114133996 114134142(alk)
PRET: 103458724(alk) 103458875
PFOR: 103144246(ltk) 103154376(alk)
GAF: 122846664(alk) 122846721(ltk)
CTUL: 119784277(ltk) 119794697(alk)
GMU: 124855392(ltk) 124855709(alk)
NFU: 107392283 107395952(alk)
KMR: 108237218(ltk) 108241771(alk)
ALIM: 106518492(alk) 106521584(ltk)
NWH: 119427309(ltk) 119427756(alk)
MCEP: 125023446(ltk) 125023860(alk)
CSEM: 103377486(ltk) 103383830(alk)
POV: 109627931(alk) 109628229
SSEN: 122782753(ltk) 122783121(alk)
HHIP: 117755931(alk) 117755943(ltk)
HSP: 118116568(ltk) 118117066(alk)
SDU: 111225567 111226063(alk)
SLAL: 111644763 111656299(alk)
XGL: 120794944(alk) 120795419(ltk)
BPEC: 110155417
MALB: 109955116(ltk) 109972827
BSPL: 114848431(ltk) 114848881(alk)
ELS: 105015742 105029147(alk)
SFM: 108919440 108940341(alk)
PKI: 111833981(alk) 111852371(ltk)
AANG: 118227667(ltk) 118236559(alk)
LOC: 102695241(ltk) 107078048
ARUT: 117403388 117411110(alk) 117422561(ltk)
LCM: 102363060 102363661(ALK)
CMK: 103176144(ltk) 103180837
RTP: 109937153
BFO: 118415382
BBEL: 109463173
APLC: 110975206
SKO: 100368524
DME: Dmel_CG8250(Alk)
DER: 6548537
DSE: 6609473
DSI: Dsimw501_GD25528(Dsim_GD25528)
DAN: 6496298
DSR: 110185803
DPO: 4805689
DPE: 6601606
DWI: 6637928
DGR: 6569115
DAZ: 108617073
DNV: 108653643
DHE: 111593842
DVI: 6625724
CCAT: 101459072
BOD: 106621438
RZE: 108359254
MDE: 101891328
LCQ: 111680623
LSQ: 119605698
HIS: 119655141
ACOZ: 120956517
AARA: 120900257
ASTE: 118503916
AAG: 5579652
AALB: 109422212
CPII: 120424431
CNS: 116340034
BCOO: 119083163
AME: 408718
ACER: 107995378
ALAB: 122711582
BIM: 100744065
BBIF: 117210364
BVK: 117237854
BVAN: 117157948
BTER: 100646372
BPYO: 122577319
CCAL: 108625215
OBB: 114870959
MGEN: 117222768
NMEA: 116428498
CGIG: 122402693
SOC: 105197862
MPHA: 105828354
AEC: 105145518
ACEP: 105626376
PBAR: 105422090
VEM: 105567635
HST: 105191722
DQU: 106752358
CFO: 105251192
LHU: 105679911
PGC: 109854323
OBO: 105276946
PCF: 106791608
PFUC: 122515836
VPS: 122635043
NVI: 100119087
CSOL: 105359312
TPRE: 106653181
MDL: 103571904
CGLO: 123268258
FAS: 105267562
DAM: 107040140
AGIF: 122860932
LHT: 122512316
CCIN: 107267482
TCA: 657445
DPA: 109534510
SOY: 115887692
ATD: 109607999
CSET: 123312831
AGB: 108917448
LDC: 111515845
NVL: 108557067
APLN: 108742590
PPYR: 116182289
OTU: 111427362
BMOR: 101735728
BMAN: 114241134
MSEX: 115453040
BANY: 112046074
NIQ: 126778415
PMAC: 106707912
PPOT: 106108690
PXU: 106125669
PRAP: 110999387
ZCE: 119835963
HZE: 124642932
TNL: 113505045
SLIU: 111357899
OFU: 114360706
PXY: 105393450
API: 100169221
AGS: 114126210
RMD: 113559828
DCI: 103509252
CLEC: 106665745
HHAL: 106682777
NLU: 111048980
FOC: 113204654
TPAL: 117639571
ZNE: 110837757
CSEC: 111875018
FCD: 110843553
DMK: 116928732
PJA: 122251639
PCLA: 123757986
PTRU: 123507264
HAZT: 108669068
LSM: 121117905
DSV: 119458092
RSAN: 119375405
VDE: 111252721
TUT: 107365132
DPTE: 113791595
DFR: 124499345
PTEP: 107456001
SDM: 118188535
CEL: CELE_T10H9.2(scd-2)
CBR: CBG_18982(Cbr-scd-2)
BMY: BM_BM5720(Bma-scd-2)
TSP: Tsp_02986
BGT: 106060200
GAE: 121371581
HRF: 124140988
MMER: 123538088
OBI: 106883653
OSN: 115209853
 » show all
Reference
PMID:9174053
  Authors
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP
  Title
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
  Journal
Oncogene 14:2175-88 (1997)
DOI:10.1038/sj.onc.1201062
  Sequence
[hsa:238]
Reference
  Authors
Palmer RH, Vernersson E, Grabbe C, Hallberg B
  Title
Anaplastic lymphoma kinase: signalling in development and disease.
  Journal
Biochem J 420:345-61 (2009)
DOI:10.1042/BJ20090387
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