KEGG ORTHOLOGY: K05474

ORTHOLOGY: K05474

Entry

K05474                      KO

Symbol

TNFSF12, TWEAK

Name

tumor necrosis factor ligand superfamily member 12

Pathway

map04060

Cytokine-cytokine receptor interaction

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05474  TNFSF12, TWEAK; tumor necrosis factor ligand superfamily member 12
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05474  TNFSF12, TWEAK; tumor necrosis factor ligand superfamily member 12
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Tumor necrosis fators
   K05474  TNFSF12, TWEAK; tumor necrosis factor ligand superfamily member 12

Other DBs

GO:

0005164

Genes

HSA:	8742(TNFSF12)

PTR:	100551503(TNFSF12)

PPS:	100978213(TNFSF12)

GGO:	101127495(TNFSF12)

PON:	103892770(TNFSF12)

PPYG:

129018186(TNFSF12)

NLE:	100607748(TNFSF12)

HMH:	116459037(TNFSF12)

SSYN:

129470373(TNFSF12)

MCC:	100551506(TNFSF12)

MCF:	102128998(TNFSF12)

MTHB:

126939796

MNI:

105473576

CSAB:

103242306(TNFSF12)

PANU:

101003015

TGE:

112609558

MLEU:

105549881(TNFSF12)

RRO:

104661648

RBB:

108514315

TFN:	117067767(TNFSF12)

PTEH:

111527042

CANG:

105523687(TNFSF12)

CJC:	100551509(TNFSF12)

SBQ:	101040464(TNFSF12)

CIMI:

108306569

ANAN:

105720797(TNFSF12)

CSYR:

103264657

MMUR:

105877544(TNFSF12)

LCAT:

123650885

ERUF:

138391894(TNFSF12)

PCOQ:

105819481(TNFSF12)

OGA:	100966364(TNFSF12)

MMU:	21944(Tnfsf12)

MCAL:

110304632(Tnfsf12)

MPAH:

110332031

RNO:	360548(Tnfsf12)

MCOC:

116079091(Tnfsf12)

ANU:	117711663(Tnfsf12)

ASYL:

127694096(Tnfsf12)

MMIU:

308425330(LOC308425330)

MUN:	110555131(Tnfsf12)

CGE:

100758527

MAUA:

101830940(Tnfsf12)

PLEU:

114693180

PMAV:

102918226(Tnfsf12)

MORG:

121457040(Tnfsf12)

MFOT:

126513935

AAMP:

119811344

CNL:	130878016(Tnfsf12)

NGI:	103752128(Tnfsf12)

HGL:	101726318(Tnfsf12)

CPOC:

106026847

CCAN:

109674287(Tnfsf12)

DORD:

105983520(Tnfsf12)

DSP:	122100374(Tnfsf12)

DMER:

138813232(Tnfsf12)

PLOP:

125365459(Tnfsf12)

NCAR:

124979912

SVUL:

306657343(ACX6B4_019775)

MMMA:

107157998(Tnfsf12)

ITI:

101977665

SCIL:

308636735(TNFSF12)

MAVE:

308275101(LOC308275101)

OCU:	100356651(TNFSF12)

OPI:

101530401

OCZ:	121170161(TNFSF12)

TUP:	106733111(TNFSF12)

GVR:	103591412(TNFSF12)

CFA:	100568280(TNFSF12)

CLUD:

112647450(TNFSF12)

VVP:	112924843(TNFSF12)

VLG:

121500710

NPO:	129496800(TNFSF12)

AML:

117796995

UMR:

121102615

UAH:	113271162(TNFSF12)

UAR:	123792142(TNFSF12)

ELK:

111161128

LLV:

125087674

MPUF:

101683696(TNFSF12)

MNP:	132004444(TNFSF12)

MLK:	131816160(TNFSF12)

NVS:

122906711

MMAQ:

308356593(LOC308356593)

ORO:	105757318(TNFSF12)

EJU:

114225391

ZCA:

113908273

MLX:

118000025

MANO:

123854623(TNFSF12)

NSU:

110584488

LWW:	102742986(TNFSF12)

FCA:

101098755

PYU:	121015752(TNFSF12)

PBG:

122484896

PVIV:

125152061(TNFSF12)

LRUF:

124519725

LGF:

123604335

AJU:

106972496

PPAD:

109246087(TNFSF12)

PUC:

125926173

PLEZ:

122206815(TNFSF12)

HHV:	120231371(TNFSF12)

CCRU:

144217211(TNFSF12)

BTA:	100551513(TNFSF12) 100568284

BOM:	102267096(TNFSF12)

BJV:	133231396 133231399 133231401

BBUB:

102394692 102405747

BKE:

129649342

BBIS:

104990771(TNFSF12)

CHX:	102191371(TNFSF12)

OAS:	101122801(TNFSF12)

OCAN:

138447462(TNFSF12)

CSUM:

138082945(TNFSF12)

ODA:	120859445(TNFSF12)

CCAD:

122445899(TNFSF12)

MREE:

136149636(TNFSF12)

OVR:	110121793(TNFSF12)

MBEZ:

129542964 129543098

SSC:	100127163(TNFSF12)

CFR:

102507653

CBAI:

105077578(TNFSF12)

CDK:

105103023

VPC:	102541703(TNFSF12)

BACU:

103017468(TNFSF12)

LVE:	103085343(TNFSF12)

OOR:	101288715(TNFSF12)

LALB:

132510659(TNFSF12)

GMF:	115855888(TNFSF12)

DDP:	132415254(TNFSF12)

SCOO:

307177488(TNFSF12)

DLE:	111185779(TNFSF12)

PCAD:

102989225 114487561(TNFSF12)

PSIU:

116745999

PPHC:

136137976(TNFSF12)

NASI:

112401877(TNFSF12)

HAMP:

307068524(TNFSF12)

ECB:	100061872(TNFSF12)

EPZ:	103557715(TNFSF12)

EAI:	106844213(TNFSF12)

MYB:	102242309(TNFSF12)

MYD:	102755642(TNFSF12)

MMYO:

118672072(TNFSF12)

MLF:	102424993(TNFSF12)

MDT:	132218067(TNFSF12)

MYUM:

138995148(TNFSF12)

PKL:	118726808(TNFSF12)

EFUS:

103296909(TNFSF12)

POTS:

308255091(AC0HY7_021924)

MNA:	107544616(TNFSF12)

DRO:	112308580(TNFSF12)

SHON:

118974724(TNFSF12)

AJM:	119053545(TNFSF12)

PDIC:

114515069(TNFSF12)

PHAS:

123809355

MMF:	118634674(TNFSF12)

PPAM:

129072297(TNFSF12)

HAI:	109394633(TNFSF12)

RFQ:	117013812(TNFSF12)

RHII:

308495693(TNFSF12)

PALE:

102886275

PGIG:

120589667

PVP:

105291216

RAY:	107506404(TNFSF12)

MJV:	108404277(TNFSF12)

TOD:	119232789(TNFSF12)

SARA:

101537535

SFUM:

130024229(TNFSF12)

SETR:

125997983(TNFSF12)

LAV:

100662597

TMU:

101356121

ETF:	101652439(TNFSF12)

DNM:	101445402(TNFSF12)

MDO:	100551511(TNFSF12)

GAS:	123244702(TNFSF12)

SHR:

111720637

AFZ:

127560879

PBRV:

138173972(TNFSF12)

TACU:

119947340(TNFSF12)

CCAY:

125628543

CPIC:

101937482

TST:	117869970(TNFSF12)

CABI:

116839654(TNFSF12)

MRV:	120381505(TNFSF12)

EMQ:

137162183

ASAO:

132779173(TNFSF12)

SUND:

121933940

PMUR:

107297237(TNFSF12)

TSR:

106546072

PMUA:

114582321(TNFSF12)

PRAF:

128400086(TNFSF12)

ZVI:	118095121(TNFSF12)

HCG:	128329517(TNFSF12)

GJA:	107119814(TNFSF12)

STOW:

125444433(TNFSF12)

EMC:

129340003

XLA:	108703544 108711778

XTR:	105945543(tnfsf12)

NPR:	108801785(TNFSF12)

RTEM:

ACAT:

PADS:

BBUF:

BGAR:

122925598(TNFSF12)

DTC:

141049907

PWL:	138268736(TNFSF12)

DRE:	567542(tnfsf12)

DAES:

130231799(tnfsf12)

SRX:	107707060 107738012

SANH:

107683554 107702061

SGH:	107595327 107597050

CCAR:

109066054 109091496

CAUA:

113052195 113105637

CGIB:

127962110 128017204

PTET:

122349255(tnfsf12)

LROH:

127167638(tnfsf12)

GRF:	141332163(tnfsf12)

OMC:	131544077(tnfsf12)

PPRM:

120469998(tnfsf12)

RKG:	130077575(tnfsf12)

SCEP:

307155296(tnfsf12)

PPHX:

306984356(tnfsf12)

MAMB:

125265553(tnfsf12)

CIDE:

127516822

CERY:

137031112(tnfsf12)

MASI:

127446872 127456629

TROS:

130554557(tnfsf12)

TDW:	130418282(tnfsf12)

MANU:

129439239(tnfsf12)

PDAB:

135730707(tnfsf12)

IPU:

108267687

IFU:	128610088(tnfsf12)

PHYP:

113540240(tnfsf12)

SMEO:

124387441(tnfsf12)

TFD:	113635228(tnfsf12)

TVC:	132848659(tnfsf12)

CGAR:

128526605(tnfsf12)

NGRA:

132864300(tnfsf12)

TRN:	134311592(tnfsf12)

AMEX:

103042685(tnfsf12)

CMAO:

118825764(tnfsf12)

EEE:	113579788(tnfsf12)

CHAR:

105907162(tnfsf12)

SPIL:

134059753(sat2a.1)

ASAD:

121690482(tnfsf12)

TRU:	101074119(tnfsf12)

TFS:	130523299(tnfsf12)

TNG:	GSTEN00024352G001

NCC:	104965168(tnfsf12)

TBEN:

117488070(tnfsf12)

CGOB:

115023923(tnfsf12)

PGEO:

117464037(tnfsf12)

GACU:

117539194(tnfsf12)

EMAC:

134876330(tnfsf12)

ELY:	117246086(tnfsf12)

EFO:	125883452(tnfsf12)

PLEP:

121962523(tnfsf12)

SLUC:

116043259(tnfsf12)

SVIT:

144534169(tnfsf12)

ECRA:

117934966(tnfsf12)

ESP:	116706967(tnfsf12)

PFLV:

114546235(tnfsf12)

PFLT:

120573609(tnfsf12)

GAT:	120821955(tnfsf12)

PPUG:

119223220(tnfsf12)

AFB:	129093742(tnfsf12)

CLUM:

117747404(tnfsf12)

PSWI:

130211693(tnfsf12)

CANA:

137791962(tnfsf12)

TBU:	306733431(tnfsf12)

AMIR:

142950969(tnfsf12)

MSAM:

119911735(tnfsf12)

SCHU:

122870642(tnfsf12)

EARM:

139306017(tnfsf12)

CUD:	121504844(tnfsf12)

SPUL:

138600864(tnfsf12)

LMIX:

132958295(tnfsf12)

HTC:	141784571(tnfsf12)

ALAT:

119027819(tnfsf12)

ASTR:

137590931(tnfsf12)

PKLU:

139222943(tnfsf12)

LCO:	104927602(tnfsf12)

AMMM:

307269557(tnfsf12)

MZE:	101477782(tnfsf12)

ONL:	100698596(tnfsf12)

OAU:	116327728(tnfsf12)

OLA:	101167575(tnfsf12)

OML:	112156479(tnfsf12)

CSAI:

133420730(tnfsf12)

XMA:	102221513(tnfsf12)

XCO:	114157708(tnfsf12)

XHE:	116733003(tnfsf12)

PRET:

103480523(tnfsf12)

PFOR:

103137562(tnfsf12)

PLAI:

106954570(tnfsf12)

PMEI:

106923998(tnfsf12)

GAF:	122820102(tnfsf12)

PPRL:

129379412(tnfsf12)

CVG:	107095620(tnfsf12)

CTUL:

119773403(tnfsf12)

GMU:	124881152(tnfsf12)

NFU:	107377311(tnfsf12)

KMR:	108247793(tnfsf12)

ALIM:

106522938

NWH:	119416475(tnfsf12)

LTU:	140281887(tnfsf12)

TBT:	306768900(tnfsf12)

MCEP:

124998746(tnfsf12)

AOCE:

111573218(tnfsf12)

EJA:	138210633(tnfsf12)

BFRE:

138633003(tnfsf12)

LCF:	108902465(tnfsf12)

CSEM:

103388027

POV:	109641238(tnfsf12)

SSEN:

122766944(tnfsf12)

SSOE:

131457105(tnfsf12)

HHIP:

117779398(tnfsf12)

HSP:	118102700(tnfsf12)

PPLT:

128430188(tnfsf12)

SMAU:

118291351(tnfsf12)

SDU:	111235686(tnfsf12)

SLAL:

111647218(tnfsf12)

XGL:	120797649(tnfsf12)

HCQ:

109508440

SSCV:

125990656(tnfsf12)

SBIA:

133494362(tnfsf12)

PEE:	133397584(tnfsf12)

PTAO:

133472362(tnfsf12)

BPEC:

110172045(tnfsf12)

ENY:	140371698(tnfsf12)

MALB:

109966519(tnfsf12)

BSPL:

114847235(tnfsf12)

SJO:	128383831(tnfsf12)

SSCO:

134005790(tnfsf12)

TTY:	137174274(tnfsf12)

GMH:	115529109(tnfsf12)

ZFA:	307246896(tnfsf12)

SASA:

106577651 106608761

STRU:

115194295 115198297

OTW:	112233852 112259946

OMY:	110500573 110531703

OGO:	124008724 124013938

ONE:	115133522 115138051

OKI:	109897008 109906839

OKE:	118368797 118392010

OMM:	135510588 135516306

OCLA:

139378963 139416077

SALP:

111953797 111960055

SNH:	120030612 120049240

SFON:

129835286 129865701

CCLU:

121554345 121572986

ELS:	105031482(tnfsf12)

OEP:	134009982(tnfsf12)

SFM:	108922898(tnfsf12)

PKI:	111854490(tnfsf12)

AANG:

118224143(tnfsf12)

AROT:

135251425(tnfsf12)

CCOG:

133124378(tnfsf12)

LOC:	102693200(tnfsf12)

PSPA:

121305586(tnfsf12) 121306572

ARUT:

117404569 117967977(tnfsf12)

LCM:	102358968(TNFSF12)

CPLA:

122544309(tnfsf12)

CPUN:

140492603(tnfsf12)

HOC:	132835177(tnfsf12)

SCAU:

119958397(tnfsf12)

LERI:

129694255(tnfsf12)

BFO:

BBEL:

SLIU:

CRG:

LAK:

Reference

PMID:14555214

Authors

Gaur U, Aggarwal BB

Title

Regulation of proliferation, survival and apoptosis by members of the TNF superfamily.

Journal

Biochem Pharmacol 66:1403-8 (2003)
DOI:10.1016/S0006-2952(03)00490-8

Reference

PMID:11796220

Authors

Bodmer JL, Schneider P, Tschopp J.

Title

The molecular architecture of the TNF superfamily.

Journal

Trends Biochem Sci 27:19-26 (2002)
DOI:10.1016/S0968-0004(01)01995-8

Reference

PMID:9405449

Authors

Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL

Title

TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.

Journal

J Biol Chem 272:32401-10 (1997)
DOI:10.1074/jbc.272.51.32401

Sequence

[hsa:8742]

LinkDB

DBGET integrated database retrieval system