KEGG   ORTHOLOGY: K07211
Entry
K07211                      KO                                     
Symbol
IKBKE, IKKE
Name
inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
Pathway
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04936  Alcoholic liver disease
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05207  Chemical carcinogenesis - receptor activation
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   04621 NOD-like receptor signaling pathway
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   04622 RIG-I-like receptor signaling pathway
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   04623 Cytosolic DNA-sensing pathway
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   04625 C-type lectin receptor signaling pathway
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   04657 IL-17 signaling pathway
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
  09172 Infectious disease: viral
   05161 Hepatitis B
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05160 Hepatitis C
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05171 Coronavirus disease - COVID-19
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05164 Influenza A
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05162 Measles
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05168 Herpes simplex virus 1 infection
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05169 Epstein-Barr virus infection
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
   05165 Human papillomavirus infection
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon
Other DBs
GO: 0008384
Genes
HSA: 9641(IKBKE)
PTR: 742813(IKBKE)
PPS: 100992569(IKBKE)
GGO: 101125384(IKBKE)
PON: 100448480(IKBKE)
NLE: 100605137(IKBKE)
MCC: 695607(IKBKE)
MCF: 102126428(IKBKE)
CSAB: 103230198(IKBKE)
CATY: 105576636(IKBKE)
PANU: 101001355(IKBKE)
TGE: 112606745(IKBKE)
RRO: 104661734(IKBKE)
RBB: 108535149(IKBKE)
TFN: 117074249(IKBKE)
PTEH: 111522719(IKBKE)
CJC: 100392518(IKBKE)
SBQ: 101027871(IKBKE)
CSYR: 103257998(IKBKE)
MMUR: 105868963(IKBKE)
OGA: 100941040(IKBKE)
MMU: 56489(Ikbke)
MCAL: 110301565(Ikbke)
MPAH: 110321718(Ikbke)
RNO: 363984(Ikbke)
MCOC: 116098877(Ikbke)
MUN: 110550327(Ikbke)
CGE: 100761646(Ikbke)
PLEU: 114698057(Ikbke)
NGI: 103725939(Ikbke)
HGL: 101697947(Ikbke)
CPOC: 100716187(Ikbke)
CCAN: 109697216(Ikbke)
DORD: 105986544(Ikbke)
DSP: 122109675(Ikbke)
NCAR: 124962122
OCU: 100354455(IKBKE)
OPI: 101529588(IKBKE)
TUP: 102481203(IKBKE)
CFA: 478950(IKBKE)
VVP: 112914364(IKBKE)
VLG: 121501599(IKBKE)
AML: 100465112(IKBKE)
UMR: 103671004(IKBKE)
UAH: 113242466(IKBKE)
UAR: 123785662(IKBKE)
ELK: 111151174
LLV: 125085960
MPUF: 101689805(IKBKE)
ORO: 101366827(IKBKE)
EJU: 114221921(IKBKE)
ZCA: 113932728(IKBKE)
MLX: 118014127(IKBKE)
FCA: 101086282(IKBKE)
PYU: 121021584(IKBKE)
PBG: 122476520(IKBKE)
PTG: 102963614(IKBKE)
PPAD: 109257640(IKBKE)
AJU: 106972924(IKBKE)
HHV: 120228866(IKBKE)
BTA: 533216(IKBKE)
BOM: 102271506(IKBKE)
BIU: 109570721(IKBKE)
BBUB: 102398659(IKBKE)
CHX: 102183809(IKBKE)
OAS: 101116923(IKBKE)
ODA: 120879941(IKBKE)
CCAD: 122451810(IKBKE)
SSC: 100519508(IKBKE)
CFR: 102519234(IKBKE)
CBAI: 105075432(IKBKE)
CDK: 105098613(IKBKE)
VPC: 102539212(IKBKE)
BACU: 103013616(IKBKE)
LVE: 103080924(IKBKE)
OOR: 101273673(IKBKE)
DLE: 111184753(IKBKE)
PCAD: 102994478(IKBKE)
PSIU: 116743242(IKBKE)
ECB: 100055384(IKBKE)
EPZ: 103553835(IKBKE)
EAI: 106823378(IKBKE)
MYB: 102248515(IKBKE)
MYD: 102760291(IKBKE)
MMYO: 118672786(IKBKE)
MLF: 102441851(IKBKE)
MNA: 107538891(IKBKE)
PKL: 118721500(IKBKE)
HAI: 109386512(IKBKE)
DRO: 112318201(IKBKE)
SHON: 119001656(IKBKE)
AJM: 119056820(IKBKE)
PDIC: 114512155(IKBKE)
PHAS: 123820660(IKBKE)
MMF: 118637482(IKBKE)
RFQ: 117014466(IKBKE)
PALE: 102889768(IKBKE)
PGIG: 120617936(IKBKE)
PVP: 105300734(IKBKE)
RAY: 107502229(IKBKE)
MJV: 108390202(IKBKE)
TOD: 119234149(IKBKE)
SARA: 101552901(IKBKE)
LAV: 100663886(IKBKE)
TMU: 101344779
DNM: 101413159(IKBKE)
MDO: 100019578(IKBKE)
GAS: 123244187(IKBKE)
SHR: 100934784(IKBKE)
PCW: 110219596(IKBKE)
OAA: 100077063(IKBKE)
GGA: 430480(IKBKE)
PCOC: 116236999(IKBKE)
MGP: 100548215(IKBKE)
CJO: 107324928(IKBKE)
NMEL: 110388051(IKBKE)
APLA: 101800153(IKBKE)
ACYG: 106041301(IKBKE)
AFUL: 116498781(IKBKE)
TGU: 100228860(IKBKE)
LSR: 110473091(IKBKE)
SCAN: 103822391(IKBKE)
PMOA: 120497659(IKBKE)
OTC: 121345534(IKBKE)
PRUF: 121349785(IKBKE)
GFR: 102043917(IKBKE)
FAB: 101814828(IKBKE)
PHI: 102105384(IKBKE)
PMAJ: 107214767(IKBKE)
CCAE: 111939780(IKBKE)
CCW: 104692514(IKBKE)
ETL: 114063148(IKBKE)
FPG: 101911668(IKBKE)
FCH: 102050482(IKBKE)
CLV: 102088357(IKBKE)
EGZ: 104134342(IKBKE)
NNI: 104013118(IKBKE)
ACUN: 113488792(IKBKE)
TALA: 116965580(IKBKE)
PADL: 103919787(IKBKE)
ACHC: 115335388(IKBKE)
AAM: 106482786(IKBKE)
AROW: 112971687(IKBKE)
NPD: 112944634(IKBKE)
DNE: 112990380(IKBKE)
ASN: 102372815(IKBKE)
AMJ: 102560016(IKBKE)
CPOO: 109317718(IKBKE)
GGN: 109295258(IKBKE)
PSS: 102464043(IKBKE)
CMY: 102930512(IKBKE)
CPIC: 101934458(IKBKE)
TST: 117875769(IKBKE)
CABI: 116832079(IKBKE)
MRV: 120403394(IKBKE)
ACS: 100562496(ikbke)
PVT: 110088412(IKBKE)
SUND: 121928472(IKBKE)
PBI: 103055936(IKBKE)
VKO: 123031375(IKBKE)
PMUA: 114599921(IKBKE)
ZVI: 118088913(IKBKE)
GJA: 107115324(IKBKE)
STOW: 125433953(IKBKE)
XLA: 108709484(ikbke.S) 734896(ikbke.L)
XTR: 100487744(ikbke)
BBUF: 120995009(IKBKE)
BGAR: 122933455(IKBKE)
DRE: 437024(ikbke)
SANH: 107655948 107675825(ikbke)
CCAR: 109087965
CAUA: 113111232(ikbke)
PPRM: 120480249(ikbke)
MAMB: 125256115(ikbke)
IPU: 108255225(ikbke)
PHYP: 113539673(ikbke)
SMEO: 124402582(ikbke)
TFD: 113641565(ikbke)
AMEX: 103047687(ikbke)
EEE: 113579176
TRU: 101074146(ikbke)
LCO: 104925246(ikbke)
NCC: 104959970(ikbke)
CGOB: 115008674(ikbke)
ELY: 117256447(ikbke)
PLEP: 121953671(ikbke)
SLUC: 116066925(ikbke)
ECRA: 117943776(ikbke)
PFLV: 114554004(ikbke)
GAT: 120834558(ikbke)
PPUG: 119229939(ikbke)
MSAM: 119886536(ikbke)
CUD: 121507196(ikbke)
MZE: 101472997(ikbke)
ONL: 100695544(ikbke)
OAU: 116326446(ikbke)
OLA: 101168283(ikbke)
OML: 112145751(ikbke)
XMA: 102228722
XCO: 114135317
XHE: 116710100
PRET: 103464875(ikbke)
PFOR: 103144323(ikbke)
PLAI: 106958353(ikbke)
PMEI: 106933981(ikbke)
GAF: 122834259(ikbke)
CVG: 107083313(ikbke)
CTUL: 119791731(ikbke)
GMU: 124857427(ikbke)
NFU: 107385596(ikbke)
KMR: 108235567(ikbke)
ALIM: 106513309(ikbke)
NWH: 119411945(ikbke)
AOCE: 111566565(ikbke)
CSEM: 103386082(ikbke)
POV: 109643466
SSEN: 122768639(ikbke)
HHIP: 117762055(ikbke)
LCF: 108890009(ikbke)
SDU: 111221468(ikbke)
SLAL: 111667666(ikbke)
XGL: 120783001(ikbke)
HCQ: 109522194
BPEC: 110156014
MALB: 109956286
SASA: 106565715
OTW: 112244673(ikbke)
OMY: 110493262(ikbke)
OGO: 124003990
ONE: 115121927(ikbke)
SNH: 120042517(ikbke)
ELS: 105017402
SFM: 108938249(ikbke)
PKI: 111854439(ikbke)
AANG: 118211103(ikbke)
LOC: 102692331(ikbke)
LCM: 102364129(IKBKE)
CMK: 103182410(ikbke)
OSN: 115209342
 » show all
Reference
  Authors
Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S
  Title
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
  Journal
Int Immunol 11:1357-62 (1999)
DOI:10.1093/intimm/11.8.1357
  Sequence
[hsa:9641]
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