KEGG ORTHOLOGY: K13708

ORTHOLOGY: K13708

Entry

K13708                      KO

Symbol

DOCK1

Name

dedicator of cytokinesis protein 1

Pathway

map04148

Efferocytosis

map04510

Focal adhesion

map04666

Fc gamma R-mediated phagocytosis

map04810

Regulation of actin cytoskeleton

map05100

Bacterial invasion of epithelial cells

map05131

Shigellosis

map05135

Yersinia infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K13708  DOCK1; dedicator of cytokinesis protein 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K13708  DOCK1; dedicator of cytokinesis protein 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K13708  DOCK1; dedicator of cytokinesis protein 1
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K13708  DOCK1; dedicator of cytokinesis protein 1
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K13708  DOCK1; dedicator of cytokinesis protein 1
   05135 Yersinia infection
    K13708  DOCK1; dedicator of cytokinesis protein 1
   05100 Bacterial invasion of epithelial cells
    K13708  DOCK1; dedicator of cytokinesis protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K13708  DOCK1; dedicator of cytokinesis protein 1
Membrane trafficking [BR:ko04131]
Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    K13708  DOCK1; dedicator of cytokinesis protein 1

Other DBs

GO:	0005085 0005096

Genes

HSA:	1793(DOCK1)

PTR:	104001055(DOCK1)

PPS:	100971564(DOCK1)

GGO:	101127665(DOCK1)

PON:	100462022(DOCK1)

PPYG:

129045209(DOCK1)

NLE:	100593551(DOCK1)

HMH:	116482053(DOCK1)

SSYN:

129464422(DOCK1)

MCC:	700788(DOCK1)

MCF:	102131974(DOCK1)

MTHB:

126962552

MNI:	105470532(DOCK1)

CSAB:

103216694(DOCK1)

CATY:

105578039(DOCK1)

PANU:

101003085(DOCK1)

TGE:	112631304(DOCK1)

MLEU:

105530187(DOCK1)

RRO:	104658119(DOCK1)

RBB:	108519578(DOCK1)

TFN:	117064910(DOCK1)

PTEH:

111550784(DOCK1)

CANG:

105503321(DOCK1)

CJC:	100411936(DOCK1)

SBQ:	101053057(DOCK1)

CIMI:

108310755(DOCK1)

ANAN:

105725212(DOCK1)

CSYR:

103254912(DOCK1)

MMUR:

105880385(DOCK1)

LCAT:

123650394(DOCK1)

PCOQ:

105819174(DOCK1)

OGA:	100963112(DOCK1)

MMU:	330662(Dock1)

MCAL:

110298899(Dock1)

MPAH:

110337335(Dock1)

RNO:	309081(Dock1)

MCOC:

116103130(Dock1)

ANU:	117703414(Dock1)

ASYL:

127694806(Dock1)

MUN:	110552822(Dock1)

CGE:

100773370

MAUA:

106020891(Dock1)

PROB:

127228469(Dock1)

PLEU:

114692902(Dock1)

MORG:

121457447(Dock1)

MFOT:

126498252

AAMP:

119814464(Dock1)

NGI:	103733379 103744273

HGL:	101718612(Dock1)

CPOC:

100734315(Dock1)

CCAN:

109688773 109688780(Dock1)

DORD:

105989761(Dock1)

DSP:	122126811(Dock1)

DMER:

138819830(Dock1)

PLOP:

125345944(Dock1)

NCAR:

124984428

MMMA:

107152920(Dock1)

ITI:	101961691(Dock1)

OCU:

100342405

OPI:	105941538(DOCK1)

TUP:	102475352(DOCK1)

CFA:	486934(DOCK1)

CLUD:

112672498(DOCK1)

VVP:	112928864(DOCK1)

VLG:	121484894(DOCK1)

NPO:	129523421(DOCK1)

AML:	100469133(DOCK1)

UMR:	103658181(DOCK1)

UAH:	113252052(DOCK1)

UAR:	123800053(DOCK1)

ELK:

111145075

LLV:

125085231

MPUF:

101681503(DOCK1)

MNP:	132016872(DOCK1)

MLK:	131830547(DOCK1)

NVS:	122901212(DOCK1)

ORO:	101364900(DOCK1)

EJU:	114221826(DOCK1)

ZCA:	113921179(DOCK1)

MLX:	117997741(DOCK1)

NSU:	110592745(DOCK1)

FCA:	101084320(DOCK1)

PYU:	121037487(DOCK1)

PCOO:

112854745(DOCK1)

PBG:	122493380(DOCK1)

PVIV:

125148210(DOCK1)

LRUF:

124507224

LGF:	123577207(DOCK1)

AJU:

106987534

PTG:	102973006(DOCK1)

PPAD:

109252245(DOCK1)

PUC:

125933173

PLEZ:

122202664(DOCK1)

HHV:	120244330(DOCK1)

BTA:	537203(DOCK1)

BOM:	102266570(DOCK1)

BIU:	109553009(DOCK1)

BBUB:

102412285(DOCK1)

BBIS:

105002752(DOCK1)

CHX:	102174457(DOCK1)

OAS:	101117205(DOCK1)

BTAX:

128067963(DOCK1)

CSUM:

138070153(DOCK1)

ODA:	120873637(DOCK1)

CCAD:

122445819(DOCK1)

MREE:

136160209(DOCK1)

OVR:	110132051(DOCK1)

MBEZ:

129555249(DOCK1)

SSC:	100524831(DOCK1)

CFR:	102514294(DOCK1)

CBAI:

105067562(DOCK1)

CDK:	105100301(DOCK1)

VPC:	102540401(DOCK1)

BACU:

103011505(DOCK1)

BMUS:

118882505(DOCK1)

LVE:	103079280(DOCK1)

OOR:	101282288(DOCK1)

LALB:

132507575(DOCK1)

GMF:	115839837(DOCK1)

DDP:	132439528(DOCK1)

DLE:	111172195(DOCK1)

PCAD:

102981826(DOCK1)

PSIU:

116741200(DOCK1)

PPHC:

136136199(DOCK1)

NASI:

112403852(DOCK1)

ECB:	100055697(DOCK1)

EPZ:	103554805(DOCK1)

EAI:	106823583(DOCK1)

MYB:	102248014(DOCK1)

MYD:	102766017(DOCK1)

MMYO:

118669639(DOCK1)

MLF:	102416933 102443158

MDT:	132214445(DOCK1)

MYUM:

139021657(DOCK1)

PKL:	118719583(DOCK1)

EFUS:

103299320(DOCK1)

MNA:	107535162(DOCK1)

DRO:	112300245(DOCK1)

SHON:

118990558(DOCK1)

AJM:	119059478(DOCK1)

PDIC:

114497235(DOCK1)

PHAS:

123828686(DOCK1)

MMF:	118632127(DOCK1)

PPAM:

129077259(DOCK1)

HAI:	109389001(DOCK1)

RFQ:	117036031(DOCK1)

PALE:

102889149(DOCK1)

PGIG:

120581257(DOCK1)

RAY:	107512566(DOCK1)

MJV:	108408449(DOCK1)

TOD:	119234129(DOCK1)

SARA:

101549316(DOCK1)

SFUM:

130015938(DOCK1)

SETR:

126033605(DOCK1)

LAV:	100663543(DOCK1)

TMU:

101356962

ETF:	101664536(DOCK1)

DNM:	101412224(DOCK1)

MDO:

100020753

GAS:	123234452(DOCK1)

SHR:	100915278(DOCK1)

AFZ:

127552198

PCW:	110198948(DOCK1)

TVP:	118828098(DOCK1)

PBRV:

138172127(DOCK1)

MLAO:

141520568(DOCK1)

OAA:	103169480(DOCK1)

TACU:

119925409(DOCK1)

GGA:	423960(DOCK1)

PCOC:

116231526(DOCK1)

MGP:

100544294

CJO:	107316266(DOCK1)

TPAI:

128077582(DOCK1)

LMUT:

125693800(DOCK1)

NMEL:

110400523(DOCK1)

APLA:

101804708(DOCK1)

ACYG:

106038955(DOCK1)

CATA:

118248567(DOCK1)

AFUL:

116491116(DOCK1)

TGU:	100232121(DOCK1)

LSR:	110468444(DOCK1)

SCAN:

103814094(DOCK1)

PMOA:

120512725(DOCK1)

OTC:	121341636(DOCK1)

PRUF:

121350046(DOCK1)

ATRC:

139599271(DOCK1)

GFR:	102031457(DOCK1)

FAB:	101813165(DOCK1)

OMA:	130254713(DOCK1)

PHI:	102102389(DOCK1)

PMAJ:

107206787(DOCK1)

CCAE:

111930975(DOCK1)

CCW:	104694938(DOCK1)

CBRC:

103615333(DOCK1)

ACOE:

138112728(DOCK1)

ETL:	114065397(DOCK1)

ZAB:	102062434(DOCK1)

ZLE:	135449750(DOCK1)

SVG:	106855167(DOCK1)

MMEA:

130580732

HRT:	120755744(DOCK1)

SATI:

136363948(DOCK1)

CCIC:

134046265(DOCK1)

FPG:	101923400(DOCK1)

FCH:	102045918(DOCK1)

CCRI:

104165536

NNT:

104412106

SHAB:

115608027(DOCK1)

ACUN:

113481723(DOCK1)

TALA:

104369008(DOCK1)

ACHC:

115347969(DOCK1)

HALD:

104323464

HLE:	104840763(DOCK1)

AGEN:

126042438

HHAR:

128147499(DOCK1)

GCL:

127018094

CSTI:

104555730

LDI:

104343052

DPUB:

104306192(DOCK1)

PPUS:

135176318(DOCK1)

AVIT:

104276217

EGZ:	104122710(DOCK1)

NNI:	104022104(DOCK1)

PCAO:

104046869

PADL:

103918635(DOCK1)

AFOR:

103897945(DOCK1)

FGA:

104081002

CBOY:

140656224(DOCK1)

CLV:	102083486(DOCK1)

CNIC:

135991171(DOCK1)

PLET:

104625661

CMAC:

104481673 104486990

CUCA:

104061545(DOCK1)

BREG:

104637486(DOCK2)

OHA:	104329476(DOCK1) 104337917

CPEA:

104392476(DOCK1)

CVF:	104293258(DOCK1)

RTD:	128911598(DOCK1)

CRID:

134517131(DOCK1)

AAM:

106486689

AROW:

112966038(DOCK1)

NPD:	112949973(DOCK1)

DNE:	112992655(DOCK1)

SCAM:

104141328(DOCK1)

ASN:	102372075 102377499

AMJ:	102571995(DOCK1)

CPOO:

109323984(DOCK1)

GGN:	109287709(DOCK1)

PSS:	102452082 102459389

CMY:	102933467(DOCK1)

CCAY:

125639584(DOCK1)

DCC:	119858299(DOCK1)

CPIC:

101930937(DOCK1)

TST:	117880556(DOCK1)

CABI:

116837298(DOCK1)

MRV:	120368568(DOCK1)

ACS:	100554287(dock1)

ASAO:

132771053(DOCK1)

PVT:	110077909(DOCK1)

SUND:

121927273(DOCK1)

PBI:	103049846 103050939 103052032

PMUR:

107285398 107288945 107288952

CTIG:

120308606(DOCK1)

TSR:	106544801(DOCK1)

PGUT:

117676726(DOCK1)

PCAE:

139318500(DOCK1)

APRI:

131201241(DOCK1)

PTEX:

113439188(DOCK1)

VKO:	123031150(DOCK1)

PMUA:

114597381(DOCK1)

PRAF:

128414120(DOCK1)

ZVI:	118096593(DOCK1)

HCG:	128349292(DOCK1)

GJA:	107106401 107106402

STOW:

125437648(DOCK1)

EMC:	129332948(DOCK1)

XLA:	108696117(dock1.L) 108697392(dock1.S)

XTR:	100497783(dock1)

NPR:	108790880(DOCK1)

RTEM:

120946747(DOCK1)

ACAT:

141105693(DOCK1)

BBUF:

121006014(DOCK1)

BGAR:

122939903(DOCK1)

DTC:	141049689(DOCK1)

PWL:	138300395(DOCK1)

MUO:	115470065(DOCK1)

GSH:	117358949(DOCK1)

DRE:	572187(dock1)

SRX:	107711371 107740868

SANH:

107666886 107667825(dock1)

SGH:	107549329(dock1) 107582198 107582199

CCAR:

109055849(dock1) 109092652

CAUA:

113055842(dock1) 113081086 113083532

CGIB:

127968800 128025507

PTET:

122355147(dock1) 122355354

LROH:

127173764(dock1)

OMC:	131550812(dock1)

PPRM:

120462783(dock1)

RKG:	130090636 130104177(dock1)

MAMB:

125255120(dock1)

CIDE:

127523250

CERY:

137007378(dock1)

MASI:

127423600 127427334

TROS:

130569437(dock1)

TDW:	130438781(dock1)

MANU:

129421490(dock1)

PDAB:

135743142(dock1)

IPU:

108273880

IFU:	128617541(dock1)

PHYP:

113527712(dock1)

SMEO:

124388370(dock1)

TFD:	113634075(dock1)

TVC:	132862944(dock1)

CGAR:

128540994(dock1)

NGRA:

132898573(dock1)

TRN:	134321264(dock1)

AMEX:

103040913(dock1)

CMAO:

118809100(dock1)

EEE:	113581978(dock1)

CHAR:

105903327(dock1)

SPIL:

134069794(dock1)

TRU:	101073725(dock1)

TFS:	130524791(dock1)

TNG:	GSTEN00019642G001 GSTEN00019645G001

LCO:	104924776(dock1)

NCC:	104941394(dock1)

TBEN:

117473616(dock1)

CGOB:

115024368(dock1)

PGEO:

117464556(dock1)

GACU:

117543936(dock1)

EMAC:

134870774(dock1)

ELY:	117246889(dock1) 117247534

EFO:	125881167(dock1)

PLEP:

121958875(dock1)

SLUC:

116061081(dock1)

ECRA:

117937023(dock1)

ESP:	116670996(dock1)

PFLV:

114547823(dock1)

GAT:	120819850(dock1)

PPUG:

119213290(dock1)

AFB:	129091129(dock1)

CLUM:

117748503(dock1)

PSWI:

130203154(dock1)

CANA:

137789219(dock1)

CVE:	137892032(dock1)

MSAM:

119916625(dock1)

SCHU:

122867401(dock1)

CUD:	121528183(dock1)

SPUL:

138594040(dock1)

LMIX:

132955693(dock1)

ALAT:

119009806(dock1)

ASTR:

137588629(dock1)

MZE:	101464532(dock1)

ONL:	100711819(dock1)

OAU:	116328787(dock1)

OLA:	101155391(dock1)

OML:	112154096(dock1)

CSAI:

133419675(dock1)

XMA:	102229035(dock1)

XCO:	114151906(dock1)

XHE:	116726931(dock1)

PRET:

103481563(dock1)

PFOR:

103145111(dock1)

PLAI:

106945008(dock1)

PMEI:

106915165(dock1)

GAF:	122823794(dock1)

PPRL:

129368041(dock1)

CVG:	107085538(dock1)

CTUL:

119781919(dock1)

GMU:	124874821(dock1)

NFU:	107387527(dock1)

KMR:	108248413(dock1)

ALIM:

106516610(dock1)

NWH:	119424041(dock1)

AOCE:

111569387(dock1)

EJA:	138204830(dock1)

BFRE:

138629424(dock1)

MCEP:

125022058(dock1)

CSEM:

103381644(dock1)

POV:	109626977(dock1)

SSEN:

122759646(dock1)

SSOE:

131448290(dock1)

HHIP:

117752559(dock1)

HSP:	118100204(dock1)

PPLT:

128426666(dock1)

SMAU:

118288095(dock1)

LCF:

108899027

SDU:	111219899(dock1)

SLAL:

111655245(dock1)

XGL:	120794104(dock1)

HCQ:	109513368(dock1)

SSCV:

125991257(dock1)

SBIA:

133495377(dock1)

PEE:	133395310(dock1)

PTAO:

133468907(dock1)

BPEC:

110169990 110174602

ENY:	140369010(dock1)

MALB:

109962987(dock1)

BSPL:

114846518(dock1)

SJO:	128380909(dock1)

SSCO:

134003465(dock1)

GMH:	115530828(dock1)

OTW:

112241065

OMY:	110513667 110514830

OGO:

124018336

OKI:	116359717 116371807

OMM:	135511833 135513383

OCLA:

139381119

CCLU:

121563319 121578917

ELS:	105009268(dock1)

OEP:	134031201(dock1)

SFM:	108939644(dock1)

PKI:	111853665(dock1)

AANG:

118220844(dock1)

AROT:

135247372(dock1)

CCOG:

133115417(dock1)

LOC:	102690670(dock1)

PSPA:

121321739 121326054

ARUT:

117415126 117418396

PSEX:

120542226(dock1)

LCM:	102349010(DOCK1)

CMK:	103180276(dock1)

CPLA:

122561388(dock1)

HOC:	132826251(dock1)

LERI:

129703960(dock1)

HAKA:

140715422(dock1)

PMRN:

116940448 116941304

LRJ:	133343304 133345551

BFO:

BBEL:

CIN:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:	100375196(DOCK1)

PFLL:

139119824

DME:	Dmel_CG10379(mbc)

DER:

6555377

DSE:

6607630

DSI:	Dsimw501_GD21040(Dsim_GD21040)

DYA:	Dyak_GE10396

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23072

DNV:

108654859

DHE:

111602637

DVI:	116651748 6630532(mbc)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119678072 119682368

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135948687(mbc)

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002759

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108731077(mbc)

CCOA:

108783067

PBAR:

105422161

VEM:

105569233

COBS:

139101346(Mbc)

TLN:	139813100(Mbc)

HST:

DQU:

CFO:

FEX:

PMEC:

138932858(Mbc)

LHU:	105676513(mbc)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

CTYP:

141528288(Mbc)

FAS:

DAM:

AGIF:

CINS:

CCIN:

DSM:

NPT:	124223623(mbc)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138126158(mbc)

DPA:

109539564

ESIM:

136410068(mbc)

EFOR:

136348714(mbc)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

VCD:

MCIX:

PMAC:

PXU:

BPHI:

137925861(mbc)

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFUM:

141442522(mbc)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM252200

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138708826(mbc)

SGRE:

126355928

BROR:

134536605

IEL:

124154723

HAMR:

139691414(mbc)

FCD:

110848360

DPX:	DAPPUDRAFT_313508

DMK:

116931664

DPZ:

124350525

AFRA:

136025148

PVM:	113813518(mbc)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123767933(mbc)

CQD:	128686408(mbc)

ESN:	126984723 126993018

MNZ:

135223840

MRJ:	136842904(mbc)

PORN:

139746542(mbc)

HAZT:

108670809

EAF:

111698005

LSM:	121125936(mbc)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:	107369248 107369583

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

BMY:	BM_BM1916(Bma-ced-5)

LOA:	LOAG_02027

TSP:

Tsp_02454

HRO:	HELRODRAFT_109536

LGI:	LOTGIDRAFT_232874

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:	125654289 125660039

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_029990

SHX:	MS3_00005680

OVI:	T265_03901

EGL:

EGR_02998

LLON:

135489824

NVE:	5507279 5520946

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_58664

AQU:

100636268

DDI:	DDB_G0284725(docD)

DPP:	DICPUDRAFT_27977

DFA:	DFA_01105(docD)

ACAN:

ACA1_067840

» show all

Reference

PMID:8657152

Authors

Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M

Title

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

Journal

Mol Cell Biol 16:1770-6 (1996)
DOI:10.1128/MCB.16.4.1770

Sequence

[hsa:1793]

LinkDB

DBGET integrated database retrieval system