KEGG ORTHOLOGY: K16790

ORTHOLOGY: K16790

Entry

K16790                      KO

Symbol

SMAD5

Name

mothers against decapentaplegic homolog 5

Pathway

map04081

Hormone signaling

map04350

TGF-beta signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K16790  SMAD5; mothers against decapentaplegic homolog 5
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K16790  SMAD5; mothers against decapentaplegic homolog 5
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K16790  SMAD5; mothers against decapentaplegic homolog 5

Other DBs

GO:

0070410

Genes

HSA:	4090(SMAD5)

PTR:	745633(SMAD5)

PPS:	100969842(SMAD5)

GGO:	101137217(SMAD5)

PON:	100173534(SMAD5)

PPYG:

129036681(SMAD5)

NLE:	100580616(SMAD5)

HMH:	116471534(SMAD5)

SSYN:

129486360(SMAD5)

MCC:	712645(SMAD5)

MCF:	102137772(SMAD5)

MTHB:

126955991

MNI:	105467109(SMAD5)

CSAB:

103244588(SMAD5)

CATY:

105599809(SMAD5)

PANU:

101006755(SMAD5)

TGE:	112626184(SMAD5)

MLEU:

105531296(SMAD5)

RRO:	104659781(SMAD5)

RBB:	108516611(SMAD5)

TFN:	117065831(SMAD5)

PTEH:

111528842(SMAD5)

CANG:

105506953(SMAD5)

CJC:	100415541(SMAD5)

SBQ:	101050360(SMAD5)

CIMI:

108284288(SMAD5)

ANAN:

105706082(SMAD5)

CSYR:

103259920(SMAD5)

MMUR:

105869422(SMAD5)

LCAT:

123637802(SMAD5)

ERUF:

138393050(SMAD5)

PCOQ:

105812042(SMAD5)

OGA:	100940341(SMAD5)

MMU:	17129(Smad5)

MCAL:

110307831(Smad5)

MPAH:

110333632(Smad5)

RNO:	59328(Smad5)

MCOC:

116081446(Smad5)

ANU:	117713586(Smad5)

ASYL:

127664502(Smad5)

MUN:	110556861(Smad5)

CGE:	100754116(Smad5)

MAUA:

101836123(Smad5)

PROB:

127229156(Smad5)

PLEU:

114688821(Smad5)

PMAV:

102923071(Smad5)

MORG:

121444920 121453312

MFOT:

126502648

AAMP:

119816689(Smad5)

CNL:	130885609(Smad5)

NGI:	103733056(Smad5)

HGL:	101702009(Smad5)

CPOC:

100717571(Smad5)

CCAN:

109697355(Smad5)

DORD:

105985512(Smad5)

DSP:	122100913(Smad5)

DMER:

138807800 138809371

PLOP:

125341882(Smad5) 125343989

NCAR:

124986874

SVUL:

306651290(ACX6B4_013722) 306664203(SMAD5)

MMMA:

107144751(Smad5)

ITI:	101974404(Smad5)

SCIL:

308655595(SMAD5)

MAVE:

308269738(SMAD5)

OCU:

100342616

OPI:	101531816(SMAD5)

OCZ:	121157766(SMAD5)

TUP:	102472483(SMAD5)

GVR:	103598517(SMAD5)

CFA:	481520(SMAD5)

CLUD:

112649653(SMAD5)

VVP:	112917028(SMAD5)

VLG:	121494878(SMAD5)

NPO:	129494921(SMAD5)

AML:	100467794(SMAD5)

UMR:	103663799(SMAD5)

UAH:	113261761(SMAD5)

UAR:	123790326(SMAD5)

ELK:

111141014

LLV:

125100084

MPUF:

101687381(SMAD5)

MNP:	132028540(SMAD5)

MLK:	131832073(SMAD5)

NVS:	122891407(SMAD5)

MMAQ:

308343043(SMAD5)

ORO:	101384630(SMAD5)

EJU:	114209501(SMAD5)

ZCA:	113928962(SMAD5)

MLX:	118016664(SMAD5)

MANO:

123856711(SMAD5)

NSU:	110590997(SMAD5)

LWW:	102744981(SMAD5) 102749080

FCA:	101081602(SMAD5)

PYU:	121010738(SMAD5)

PCOO:

112860287(SMAD5)

PBG:	122487663(SMAD5)

PVIV:

125168869(SMAD5)

LRUF:

124515911

LGF:	123604077(SMAD5)

AJU:

106989154

PTG:	102962791(SMAD5)

PPAD:

109250821(SMAD5)

PUC:

125935523

PLEZ:

122217990(SMAD5)

HHV:	120238505(SMAD5)

CCRU:

144235212(SMAD5)

BTA:	768050(SMAD5)

BOM:	102281606(SMAD5)

BIU:	109562044(SMAD5)

BJV:	133251305(SMAD5)

BBUB:

102391419(SMAD5)

BKE:	129632607(SMAD5)

BBIS:

104991839(SMAD5)

CHX:	102180667(SMAD5)

OAS:	443172(SMAD5)

OCAN:

138441315(SMAD5)

BTAX:

128050940(SMAD5)

CSUM:

138085337(SMAD5)

ODA:	120863629(SMAD5)

CCAD:

122439891(SMAD5)

MREE:

136156134(SMAD5)

OVR:	110126073(SMAD5)

MBEZ:

129558295(SMAD5)

SSC:	100624262(SMAD5)

CFR:	102518120(SMAD5)

CBAI:

105082148(SMAD5)

CDK:	105090469(SMAD5)

VPC:	102531003(SMAD5)

BACU:

103005779(SMAD5)

BMUS:

118892310(SMAD5)

LVE:	103082423(SMAD5)

OOR:	101270415(SMAD5)

LALB:

132517081(SMAD5)

GMF:	115860097(SMAD5)

DDP:	132423263(SMAD5)

SCOO:

307183336(SMAD5)

PCRS:

137221696(SMAD5)

DLE:	111182474(SMAD5)

PCAD:

102992588(SMAD5)

PSIU:

116751384(SMAD5)

PPHC:

136119909(SMAD5)

NASI:

112404366(SMAD5)

HAMP:

307052496(SMAD5)

ECB:	100033851(SMAD5)

EPZ:	103554377(SMAD5)

EAI:	106822999(SMAD5)

MYB:	102259395(SMAD5)

MYD:	102775179(SMAD5)

MMYO:

118657988(SMAD5)

MLF:	102421852(SMAD5)

MDT:	132235674(SMAD5)

MYUM:

139010466(SMAD5)

PKL:	118711697(SMAD5)

EFUS:

103286485(SMAD5)

POTS:

308252168(SMAD5)

MNA:	107525371(SMAD5)

DRO:	112318116(SMAD5)

SHON:

118996207(SMAD5)

AJM:	119044160(SMAD5)

PDIC:

114509825(SMAD5)

PHAS:

123807089(SMAD5)

MMF:	118615693(SMAD5)

PPAM:

129066668(SMAD5)

HAI:	109382613(SMAD5)

RFQ:	117016717(SMAD5)

RHII:

308491494(SMAD5)

PALE:

102878188(SMAD5)

PGIG:

120581325(SMAD5)

PVP:	105293596(SMAD5)

RAY:	107506827(SMAD5)

MJV:	108410128(SMAD5)

TOD:	119243445(SMAD5)

SARA:

101539682(SMAD5)

SFUM:

130032775(SMAD5)

SETR:

126027745(SMAD5)

LAV:	100667927(SMAD5)

TMU:

101344246

ETF:	101642296(SMAD5)

DNM:	101447477(SMAD5)

MDO:	100011974(SMAD5)

GAS:	123235744(SMAD5) 123245378

SHR:	100920078(SMAD5)

AFZ:

127549797

PCW:	110211743(SMAD5)

TVP:	118841894(SMAD5)

PBRV:

138164244(SMAD5)

MLAO:

141506596(SMAD5)

OAA:	100089852(SMAD5) 114808649

TACU:

119946651 119950203(SMAD5)

GGA:	395679(SMAD5)

PCOC:

116232200(SMAD5)

MGP:	100542490(SMAD5)

CJO:	107320188(SMAD5)

TPAI:

128083942(SMAD5)

LMUT:

125700135(SMAD5)

NMEL:

110405212(SMAD5)

APLA:

101795209(SMAD5)

AACU:

137864496(SMAD5)

OJA:	118173679(SMAD5)

BCLA:

308449445(SMAD5)

ACYG:

106032785(SMAD5)

ABRC:

308177723(SMAD5)

CATA:

118254896(SMAD5)

AFUL:

116494842(SMAD5)

TGU:	100221011(SMAD5)

LSR:	110481028(SMAD5)

VMC:	128814872(SMAD5)

VCHA:

128795659(SMAD5)

AIB:	137483033(SMAD5)

SCAN:

103817268(SMAD5)

PMOA:

120498466(SMAD5)

OTC:	121332258(SMAD5)

PRUF:

121361313(SMAD5)

ATRC:

139597685(SMAD5)

MATE:

118692273(SMAD5)

MAEN:

136562968(SMAD5)

GFR:	102040705(SMAD5)

FAB:	101818667(SMAD5)

OMA:	130258641(SMAD5)

PHI:	102103977(SMAD5)

PMAJ:

107210728(SMAD5)

CCAE:

111935587(SMAD5)

CCW:	104689616(SMAD5)

CBRC:

103614671(SMAD5)

ACOE:

138117918(SMAD5)

ETL:	114068593(SMAD5)

ZAB:	102065199(SMAD5)

ZLE:	135453640(SMAD5)

ACHL:

103809073(SMAD5)

SVG:	106857376(SMAD5)

MMEA:

130576551(SMAD5)

HRT:	120759122(SMAD5)

SATI:

136367449(SMAD5)

CFAI:

136297444(SMAD5)

CCIC:

134049873(SMAD5)

NNT:

104402064

SHAB:

115615817(SMAD5)

POCC:

134173723(SMAD5)

FPG:	101924362(SMAD5)

FCH:	102058899(SMAD5)

FRS:	119152306(SMAD5)

CCRI:

104163134(SMAD5)

ACUN:

113485197(SMAD5)

ANOC:

141964910(SMAD5)

SURA:

141949982(SMAD5)

TALA:

104360472(SMAD5)

ACHC:

115334203(SMAD5)

HALD:

104318272

HLE:	104838869(SMAD5)

AGEN:

126051138

HHAR:

128155059(SMAD5)

BBUT:

142044483(SMAD5)

GCL:

127021840

CSTI:

104557158

LDI:	104351053(SMAD5)

MNB:

103772252

DPUB:

104309696(SMAD5)

PPUS:

135185423(SMAD5)

IIN:	128973178(SMAD5)

AVIT:

104277284

BRHI:

104494014(SMAD5)

EGZ:	104128895(SMAD5)

NNI:	104012492(SMAD5)

PCRI:

104033944(SMAD5)

PCAO:

104051806(SMAD5)

PARX:

142061578(SMAD5)

PADL:

103915773(SMAD5)

AFOR:

103904423(SMAD5)

FGA:

104075280

CBOR:

142088852(SMAD5)

GSTE:

104259753(SMAD5)

CBOY:

140656361(SMAD5)

MAME:

142414098(SMAD5)

CLV:	102089923(SMAD5)

CNIC:

135993875(SMAD5)

NMAY:

308045954(SMAD5)

MUI:

104538881

PGUU:

104464164

PLET:

104621295(SMAD5)

EHS:

104513095

CMAC:

104486383

CUCA:

104059149(SMAD5)

PCUR:

138727337(SMAD5)

TEO:

104373362

BREG:

104630869

GAME:

129212733(SMAD5)

OHA:	104326871(SMAD5)

ACAR:

104521554(SMAD5)

CEUR:

306721454(SMAD5)

CPEA:

104386693(SMAD5)

CVF:	104291773(SMAD5)

RTD:	128916102(SMAD5)

CRID:

134521896(SMAD5)

LMIC:

141749735(SMAD5)

NARQ:

141470538(SMAD5)

AAM:	106487236(SMAD5)

AROW:

112964741(SMAD5)

NPD:	112954272(SMAD5)

TGT:	104581003(SMAD5)

DNE:	112994076(SMAD5)

SCAM:

104141068(SMAD5)

ASN:	102377001(SMAD5)

AMJ:	102564543(SMAD5)

CPOO:

109310113(SMAD5)

GGN:	109289934(SMAD5)

PSS:	102458588(SMAD5)

CIZ:	142021148(SMAD5)

CMY:	102939491(SMAD5)

CCAY:

125641297(SMAD5)

LKP:	140915600(SMAD5)

NDS:	141991942(SMAD5)

DCC:	119860480(SMAD5)

CPIC:

101938082(SMAD5)

TST:	117881659(SMAD5)

EOB:	135882264(SMAD5)

CABI:

116822306(SMAD5)

MRV:	120370570(SMAD5)

EMQ:	137165318(SMAD5)

ACS:	100564659(smad5)

ASAO:

132768905(SMAD5)

PVT:	110073456(SMAD5)

SUND:

121922252(SMAD5)

PBI:	103050787(SMAD5)

PMUR:

107295208

CTIG:

120304371(SMAD5)

TSR:

106546387

PGUT:

117655785(SMAD5)

PCAE:

139312466(SMAD5)

APRI:

131191484(SMAD5)

PTEX:

113433769(SMAD5)

NSS:	113424983(SMAD5)

VKO:	123035774(SMAD5)

PMUA:

114591291(SMAD5)

PRAF:

128407897(SMAD5)

ZVI:	118080376(SMAD5)

HCG:	128345451(SMAD5)

GJA:	107114480(SMAD5)

STOW:

125429300(SMAD5)

EMC:	129328340(SMAD5)

PWL:	138245545(SMAD5)

MUO:	115475419(SMAD5)

GSH:	117351903(SMAD5)

DRE:	30641(smad5)

DAES:

130240505(smad5)

SRX:	107717391 107741088

SANH:

107662000 107664766

SGH:	107563595 107598346

CCAR:

109069927 109109574

CAUA:

113057806 113058073 113114252

CGIB:

127971582 128027323

PTET:

122357654(smad5)

LROH:

127176509(smad5)

GRF:	141287981(smad5)

OMC:	131553464(smad5)

PPRM:

120460947(smad5)

RKG:	130084859(smad5)

SCEP:

307171334(smad5)

MAMB:

125258916(smad5)

CIDE:

127494262

CERY:

137020236(smad5)

MASI:

127413448 127417995

TROS:

130563995(smad5)

TDW:	130438036(smad5)

MANU:

129422413(smad5)

PDAB:

135753756(smad5)

IPU:

108269226

IFU:	128611449(smad5)

PHYP:

113529124(smad5)

SMEO:

124385770(smad5)

TFD:	113635807(smad5)

TVC:	132855671(smad5)

CGAR:

128531673(smad5)

NGRA:

132890778(smad5)

TRN:	134319442(smad5)

AMEX:

103032348(smad5)

CMAO:

118806878(smad5)

EEE:	113573390(smad5)

CHAR:

105912044(smad5)

SPIL:

134068694(smad5)

ASAD:

121694224(smad5)

TRU:	101064562(smad5)

TFS:	130531028(smad5)

TNG:	GSTEN00005726G001

NCC:

104945002

TBEN:

117475137(smad5)

CGOB:

115014807

PGEO:

117453820(smad5)

GACU:

117554707(smad5)

EMAC:

134859379(smad5)

ELY:	117261251(smad5)

EFO:	125894609(smad5)

PLEP:

121947881(smad5)

SLUC:

116036484(smad5)

SVIT:

144524698(smad5)

ECRA:

117951641(smad5)

ESP:

116685942

PFLV:

114562894

PFLT:

120566791(smad5)

GAT:	120817404(smad5)

PPUG:

119211144(smad5)

AFB:	129090069(smad5)

CLUM:

117737443(smad5)

PSWI:

130209608(smad5)

CANA:

137779384(smad5)

TBU:	306746198(smad5)

CVE:	137875220(smad5)

AMIR:

142962831(smad5)

MSAM:

119888841(smad5)

SCHU:

122879846(smad5)

EARM:

139291843(smad5)

CUD:	121516071(smad5)

SPUL:

138598032(smad5)

LMIX:

132982314(smad5)

HTC:	141793593(smad5)

ALAT:

119007654(smad5)

ASTR:

137602911(smad5)

PKLU:

139206972(smad5)

LCO:

104920560

AMMM:

307256398(smad5)

MZE:	101464356(smad5)

ONL:

100706145

OAU:	116328131(smad5)

OLA:

101160003

OML:	112153580(smad5)

CSAI:

133447257(smad5)

XMA:

102227900

XCO:

114139311

XHE:

116714533

PRET:

103471035(smad5)

PFOR:

103149303

PLAI:

106957970

PMEI:

106928919

GAF:	122837217(smad5)

PPRL:

129362600(smad5)

CVG:

107090159

CTUL:

119797268(smad5)

GMU:	124860378(smad5)

NFU:

107378051

KMR:	108250437(smad5)

ALIM:

106531705

NWH:	119408597(smad5)

LTU:	140318385(smad5)

MCEP:

125008154(smad5)

AOCE:

111565189(smad5)

EJA:	138211413(smad5)

BFRE:

138628860(smad5)

LCF:	108878855(smad5)

CSEM:

103391130

POV:

109626568

SSEN:

122778506(smad5)

SSOE:

131472621(smad5)

HHIP:

117769434(smad5)

HSP:	118112333(smad5)

PPLT:

128446045(smad5)

SMAU:

118319462(smad5)

SDU:

111226621

SLAL:

111646480

XGL:	120785224(smad5)

HCQ:

109515784

SSCV:

125967296(smad5)

SBIA:

133509138(smad5)

PEE:	133407711(smad5)

PTAO:

133485166(smad5)

BPEC:

110168343

ENY:	140370072(smad5)

MALB:

109957561

BSPL:

114864524(smad5)

SJO:	128363061(smad5)

SSCO:

133985873(smad5)

TTY:	137189012(smad5)

GMH:

115552280

SASA:

100195462(smad5) 106604135

STRU:

115167106 115205737

OTW:	112237239 112255860

OMY:	110489194(smad5) 110504484

OGO:	123993738(smad5) 124010921

ONE:	115115619 115118232

OKI:	109865020(smad5) 109878031

OKE:	118372838 118381759(smad5)

OMM:	135526760 135545467

OCLA:

139366571 139390923

SALP:

111966015 111967178

SNH:	120047877 120062512

SFON:

129827451 129858501

CCLU:

121530692 121538602

ELS:	105005996(smad5)

OEP:	134032316(smad5)

SFM:	108923083(smad5)

PKI:	111836416(smad5)

AANG:

118223514(smad5)

AROT:

135251087(smad5)

CCOG:

133124506(smad5)

LOC:

102682912

PSPA:

121297214 121324621

ARUT:

117412980 117431188

PSEX:

120542020(smad5)

LCM:	102362811(SMAD5)

CMK:	103183712(smad5)

RTP:	109923395 109923561(smad9)

CPLA:

122550807(smad9) 122556620

CPUN:

140481269(smad9) 140492059(smad5)

HOC:	132816493(smad9) 132823415(smad5)

SCAU:

119965277(smad5) 119977699(smad9)

STOZ:

140391955(smad9) 140426986

CMAM:

144682696(smad9) 144685889(smad5)

LERI:

129701764(smad5)

HAKA:

140739304

BFO:

118419549

BBEL:

109470611

CIN:	778754(smad1/5)

SPU:

LPIC:

APLC:

PMIN:

ARUN:

AFIL:

AJC:

TUT:

NAI:	NECAME_14425

LGI:	LOTGIDRAFT_104873

LSAX:

HCRA:

CRG:

CANU:

CVN:	111125017 111125137

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LAK:

SMM:	Smp_013060

SHX:	MS3_00005346(SMAD9_1) MS3_00009779(SMAD9_10)

OVI:	T265_01150

EGL:

LLON:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

XEN:

HMG:	100211577(LOC100211577)

RES:

135682351

TAD:	TRIADDRAFT_50301

» show all

Reference

PMID:10207140

Authors

Hild M, Dick A, Rauch GJ, Meier A, Bouwmeester T, Haffter P, Hammerschmidt M

Title

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo.

Journal

Development 126:2149-59 (1999)

Sequence

[dre:30641]

Reference

PMID:21615335

Authors

Santibanez JF, Quintanilla M, Bernabeu C

Title

TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions.

Journal

Clin Sci (Lond) 121:233-51 (2011)
DOI:10.1042/CS20110086

LinkDB

DBGET integrated database retrieval system