KEGG ORTHOLOGY: K20423

ORTHOLOGY: K20423

Entry

K20423                      KO

Symbol

ncsB2

Name

2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase [EC:6.2.1.43]

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00830

Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA

Reaction

R10771

2-hydroxy-7-methoxy-5-methyl-1-naphthoate:CoA ligase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
Enzymes [BR:ko01000]
6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.43  2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
     K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Others
   K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase

Other DBs

COG:

COG1021

Genes

PROD:

PCO85_04745

BSAV:

WS86_20930

BHG:	I6G56_26270

CBRE:

QP027_12190

MTS:

MTES_3604

ARTP:

E5206_14865

APN:	Asphe3_39850

PSUL:

AU252_00410

AOI:	AORI_6598(dhbE)

AORI:

AROO:

SAQ:

MICH:

ACTN:

AG:	AAM77987(ncsB2)

» show all

Reference

PMID:17539640

Authors

Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD

Title

Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Journal

J Am Chem Soc 129:7728-9 (2007)
DOI:10.1021/ja071886a

Sequence

[ag:AAM77987]

LinkDB

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