KEGG ORTHOLOGY: K23488

ORTHOLOGY: K23488

Entry

K23488                      KO

Symbol

RAPH1

Name

Ras-associated and pleckstrin homology domains-containing protein 1

Pathway

map04361

Axon regeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K23488  RAPH1; Ras-associated and pleckstrin homology domains-containing protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K23488  RAPH1; Ras-associated and pleckstrin homology domains-containing protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
Pleckstrin homology (PH) domain-containing proteins
  Other PH domain-containing proteins
   K23488  RAPH1; Ras-associated and pleckstrin homology domains-containing protein 1

Genes

HSA:	65059(RAPH1)

PTR:	459893(RAPH1)

PPS:	100991393(RAPH1)

GGO:	101130331(RAPH1)

PON:	100448510(RAPH1)

PPYG:

129032126(RAPH1)

NLE:	100604918(RAPH1)

HMH:	116810409(RAPH1)

SSYN:

129488297(RAPH1)

MCC:	705065(RAPH1)

MCF:	102140899(RAPH1)

MTHB:

126932172

MNI:	105468063(RAPH1)

CSAB:

103217680(RAPH1)

CATY:

105580068(RAPH1)

PANU:

101025902(RAPH1)

TGE:	112636314(RAPH1)

MLEU:

105548460(RAPH1)

RRO:	104653587(RAPH1)

RBB:	108537209(RAPH1)

TFN:	117094624(RAPH1)

PTEH:

111547480(RAPH1)

CANG:

105517385(RAPH1)

CJC:	100401258(RAPH1)

SBQ:	101044587(RAPH1)

CIMI:

108310123(RAPH1)

ANAN:

105712869(RAPH1)

CSYR:

103276880(RAPH1)

MMUR:

105856927(RAPH1)

LCAT:

123643863(RAPH1)

OGA:	100942984(RAPH1)

MMU:	77300(Raph1)

MCAL:

110289975(Raph1)

MPAH:

110321841(Raph1)

RNO:	363239(Raph1)

MCOC:

116088490(Raph1)

ANU:	117705783(Raph1)

ASYL:

127692079(Raph1)

MUN:	110559993(Raph1)

CGE:	100769256(Raph1)

MAUA:

101842687(Raph1)

PROB:

127226358(Raph1)

PLEU:

114682492(Raph1)

MORG:

121452997(Raph1)

MFOT:

126508754

AAMP:

119820505(Raph1)

NGI:	103744473(Raph1)

HGL:	101700066(Raph1)

CPOC:

100714692(Raph1)

CCAN:

109688378(Raph1)

DORD:

105985390(Raph1)

DSP:	122096467(Raph1)

PLOP:

125350375(Raph1)

NCAR:

124979019

MMMA:

107138626(Raph1)

ITI:	101956204(Raph1)

OCU:

100351493

OPI:	101517524(RAPH1)

TUP:	102482393(RAPH1)

GVR:	103598272(RAPH1)

CFA:	488486(RAPH1)

CLUD:

112656770(RAPH1)

VVP:	112922848(RAPH1)

VLG:	121480670(RAPH1)

NPO:	129522827(RAPH1)

AML:

100478661

UMR:	103659766(RAPH1)

UAH:	113250561(RAPH1)

UAR:	123798225(RAPH1)

ELK:

111159924

LLV:

125095021

MPUF:

101688127(RAPH1)

MNP:	132013475(RAPH1)

MLK:	131827544(RAPH1)

NVS:	122902221(RAPH1)

ORO:	101378082(RAPH1)

EJU:	114215928(RAPH1)

ZCA:	113919884(RAPH1)

MLX:	118012120(RAPH1)

NSU:	110592036(RAPH1)

FCA:	101097999(RAPH1)

PYU:	121030937(RAPH1)

PCOO:

112872273(RAPH1)

PBG:	122481669(RAPH1)

PVIV:

125173518(RAPH1)

LRUF:

124515936

LGF:	123599339(RAPH1)

AJU:

106976713

PTG:	102956217(RAPH1)

PPAD:

109265195(RAPH1)

PUC:

125911285

PLEZ:

122226518(RAPH1)

HHV:	120224354(RAPH1) 120226155

BTA:	523153(RAPH1)

BOM:	102282489(RAPH1)

BIU:	109569750(RAPH1)

BBUB:

123465413(RAPH1)

BBIS:

105003676

CHX:	102173512(RAPH1)

OAS:	101104305(RAPH1)

BTAX:

128070833(RAPH1)

CSUM:

138076695(RAPH1)

ODA:	120854592(RAPH1)

CCAD:

122426282(RAPH1)

MREE:

136164977(RAPH1)

MBEZ:

129538230(RAPH1)

SSC:	100515060(RAPH1)

CFR:	102508106(RAPH1)

CBAI:

105082331(RAPH1)

CDK:	105098981(RAPH1)

VPC:	102526031(RAPH1)

BACU:

103016653(RAPH1)

BMUS:

118897895(RAPH1)

LVE:	103070911(RAPH1)

OOR:	101274299(RAPH1)

LALB:

132522152(RAPH1)

DLE:	111171753(RAPH1)

PCAD:

102995830(RAPH1)

PSIU:

116756655(RAPH1)

NASI:

112395257

ECB:	100067740(RAPH1)

EPZ:	103565098(RAPH1)

EAI:	106828141(RAPH1)

MYB:	102256315(RAPH1)

MYD:	102773330(RAPH1)

MMYO:

118662006(RAPH1)

MLF:	102420174(RAPH1)

MDT:	132238143(RAPH1)

MYUM:

139014944(RAPH1)

PKL:	118709772(RAPH1)

EFUS:

103290602(RAPH1)

MNA:

107533966

DRO:	112307689(RAPH1)

SHON:

118985207(RAPH1)

AJM:	119064311(RAPH1)

PDIC:

114494651(RAPH1)

PHAS:

123827091(RAPH1)

MMF:	118625319(RAPH1)

PPAM:

129080407(RAPH1)

HAI:	109379210(RAPH1)

RFQ:	117025702(RAPH1)

PALE:

102881152 112470270

PGIG:

120587553(RAPH1)

PVP:	105298424(RAPH1)

RAY:	107519364(RAPH1)

MJV:	108403788(RAPH1)

TOD:	119256128(RAPH1)

SARA:

101543709(RAPH1)

SFUM:

130020918(RAPH1)

SETR:

126008891(RAPH1)

LAV:	100655617(RAPH1)

TMU:

101342843

ETF:	101642749(RAPH1)

DNM:	101414605(RAPH1)

MDO:	100619680(RAPH1)

GAS:	123241904(RAPH1)

SHR:	100921861(RAPH1)

AFZ:

127553198

PCW:	110198520(RAPH1)

TVP:	118846161(RAPH1)

PBRV:

138151720(RAPH1)

OAA:	100078526(RAPH1)

TACU:

119930826(RAPH1)

GGA:	424107(RAPH1)

PCOC:

116234026(RAPH1)

MGP:	100543314(RAPH1)

CJO:	107316576(RAPH1)

TPAI:

128076707(RAPH1)

LMUT:

125696832(RAPH1)

NMEL:

110399205(RAPH1)

APLA:

101802548(RAPH1)

ACYG:

106030062(RAPH1)

CATA:

118261105(RAPH1)

AFUL:

116490471(RAPH1)

TGU:	100228481(RAPH1)

LSR:	110471091(RAPH1)

SCAN:

103814715(RAPH1)

PMOA:

120505783(RAPH1)

PRUF:

121356403(RAPH1)

ATRC:

139593619(RAPH1)

GFR:	102031867(RAPH1)

FAB:	101820940(RAPH1)

OMA:	130255844(RAPH1)

PHI:	102114041(RAPH1)

PMAJ:

107207229(RAPH1)

CCAE:

111932424(RAPH1)

CCW:	104694151(RAPH1)

CBRC:

103616615(RAPH1)

ACOE:

138113659(RAPH1)

ETL:	114055760(RAPH1)

ZLE:	135450054(RAPH1)

SVG:	106855533(RAPH1)

MMEA:

130577473(RAPH1)

HRT:	120754878(RAPH1)

SATI:

136363441(RAPH1)

CCIC:

134047416(RAPH1)

FPG:	101917286(RAPH1)

FCH:	102058444(RAPH1)

SHAB:

115608725(RAPH1)

ACUN:

113482550

TALA:

104363212(RAPH1)

ACHC:

115342404(RAPH1)

HLE:	104830480(RAPH1)

AGEN:

126038207

HHAR:

128143725(RAPH1)

GCL:

127018476

DPUB:

104298960(RAPH1)

PPUS:

135184994(RAPH1)

EGZ:	104125101(RAPH1)

NNI:	104010272(RAPH1)

PADL:

103923728(RAPH1)

AFOR:

103907295(RAPH1)

CBOY:

140657778(RAPH1)

CLV:	102088000(RAPH1)

CUCA:

104058305(RAPH1)

TEO:	104372574(RAPH1)

BREG:

104633892(RAPH1)

OHA:	104339678(RAPH1)

CPEA:

104387562(RAPH1)

CVF:	104291055(RAPH1)

RTD:	128913054(RAPH1)

CRID:

134518570(RAPH1)

AAM:	106492435(RAPH1)

AROW:

112977231(RAPH1)

NPD:	112955138(RAPH1)

TGT:	104573212(RAPH1)

DNE:	112992075(RAPH1)

SCAM:

104153004(RAPH1)

ASN:	102377397(RAPH1)

AMJ:	102576159(RAPH1)

CPOO:

109322622(RAPH1)

GGN:	109302024(RAPH1)

PSS:

102459817

CMY:	102947563(RAPH1)

CCAY:

125645224(RAPH1)

DCC:	119863757(RAPH1)

CPIC:

101945691(RAPH1)

TST:	117884639(RAPH1)

CABI:

116821869(RAPH1)

MRV:	120374673(RAPH1)

ACS:	100566376(raph1)

ASAO:

132779225(RAPH1)

PVT:

110090720

SUND:

121930680(RAPH1)

PBI:	103066531(RAPH1)

PMUR:

107290542(RAPH1)

CTIG:

120313221(RAPH1)

TSR:	106548367(RAPH1)

PGUT:

117673645(RAPH1)

APRI:

131200211(RAPH1)

PTEX:

113433925(RAPH1)

NSS:	113421063(RAPH1)

VKO:	123024315(RAPH1)

PMUA:

114581647(RAPH1)

PRAF:

128402118(RAPH1)

ZVI:	118096182(RAPH1)

HCG:	128338512(RAPH1)

GJA:	107107243(RAPH1)

STOW:

125425895(RAPH1)

EMC:	129323979(RAPH1)

XLA:	108703048 779189(raph1.L)

XTR:	100491727(raph1)

NPR:	108785045(RAPH1)

RTEM:

120943755(RAPH1)

BBUF:

121007854(RAPH1)

BGAR:

122944870(RAPH1)

PWL:	138285712(RAPH1)

MUO:	115474316(RAPH1)

GSH:	117361479(RAPH1)

DRE:	557435(raph1a) 560319(raph1b)

SRX:	107707841 107719733 107738113 107752894

SANH:

107654246 107668371 107688759 107705038

SGH:	107556694 107588825 107592998 107596534(raph1)

CCAR:

109067300 109088761(raph1b) 109096271(raph1a) 109096273

CAUA:

113043967 113053612 113105365 113108861

CGIB:

127948676 127965359 128015489 128019640

PTET:

122350044(raph1b) 122351622(raph1a)

LROH:

127162648(raph1b) 127170706(raph1a)

OMC:	131522727(raph1b) 131546969(raph1a)

PPRM:

120479489(raph1b) 120487077(raph1a)

RKG:	130085748(raph1a) 130087770(raph1b)

MAMB:

125270091(raph1a) 125272327(raph1b)

CIDE:

127509163 127518349

CERY:

137033113(raph1b) 137035889(raph1a)

MASI:

127443680 127447403 127447691

TROS:

130555570(raph1a)

TDW:	130427481(raph1a)

MANU:

129451432(raph1a)

PDAB:

135782516(raph1a)

IPU:	108258483(raph1b) 108266498(raph1a)

IFU:	128601760(raph1b) 128608968(raph1a)

PHYP:

113526110 113537722

SMEO:

124377894(raph1b) 124382627(raph1a)

TFD:	113648986(raph1b) 113654234(raph1a)

TVC:	132839790(raph1b) 132850293(raph1a)

CGAR:

128506313(raph1b) 128524026(raph1a)

NGRA:

132866253(raph1b) 132891971(raph1a)

TRN:	134323995(raph1a) 134328223(raph1b)

AMEX:

103040117(raph1b) 103043657(raph1a)

CMAO:

118804387(raph1b) 118806762(raph1a)

EEE:	113578549(raph1) 113585028

CHAR:

105892832(raph1a)

SPIL:

134071276(raph1b) 134078840(raph1a)

TRU:	101064095 101073885

TFS:	130522174(raph1b) 130531019

TNG:	GSTEN00021752G001 GSTEN00027148G001

LCO:	104926278 104934541

NCC:

104945519

TBEN:

117495306(raph1a) 117499231(raph1b)

CGOB:

115022018

PGEO:

117456202 117466993

GACU:

117546880(raph1b)

EMAC:

134861174(raph1b) 134867759(raph1a)

ELY:	117249748(raph1b) 117251269(raph1a)

EFO:	125884940(raph1b) 125899302(raph1a)

PLEP:

121949609 121962925(raph1b)

SLUC:

116044789(raph1b) 116053870(raph1a)

ECRA:

117939689(raph1b) 117952809(raph1a)

ESP:	116673909(raph1) 116689064

PFLV:

114551291 114564457(raph1)

GAT:	120820963(raph1b) 120834324

PPUG:

119218592(raph1b) 119228615

AFB:	129104407(raph1a) 129111605(raph1b)

CLUM:

117743264(raph1b) 117750204(raph1a)

PSWI:

130200581 130204800(raph1b)

CANA:

137783321(raph1a) 137793923(raph1b)

CVE:	137878829(raph1b) 137890019(raph1a)

MSAM:

119902719(raph1b) 119904542(raph1a)

SCHU:

122872169(raph1b) 122885034

CUD:	121506151(raph1b) 121522130(raph1a)

SPUL:

138592676 138603440(raph1b)

LMIX:

132959783(raph1b) 132986956(raph1a)

ALAT:

119015051(raph1b) 119025839

ASTR:

137591675(raph1b) 137604665(raph1a)

MZE:	101471660 101482814

ONL:	100699366 100710818

OAU:	116314047 116319216(raph1b)

OLA:	101161763 101163063

OML:	112137933 112160006(raph1b)

CSAI:

133425214(raph1b) 133446189(raph1a)

XMA:	102223180 102234542

XCO:	114138213 114148413

XHE:	116715784 116722824

PRET:

103475546

PFOR:

103147126 103149932 103149944

PLAI:

106950963 106965106

PMEI:

106905158 106933239

GAF:	122827448(raph1b) 122839464(raph1a)

PPRL:

129379096(raph1b) 129379155(raph1a)

CVG:	107093735 107097748

CTUL:

119779619(raph1b) 119794056

GMU:	124861742(raph1b) 124871056(raph1a)

NFU:	107381104 107389521

KMR:	108238867(raph1a) 108246708(raph1b)

ALIM:

106529636(raph1)

NWH:	119419441 119429029(raph1b)

AOCE:

111568744(raph1b) 111584947

EJA:	138201573(raph1a) 138208423(raph1b)

BFRE:

138620818(raph1b) 138636705(raph1a)

MCEP:

125000602(raph1b) 125018146(raph1a)

CSEM:

103389880 103391734

POV:	109640965 109643486 109644577

SSEN:

122758413(raph1b) 122760145

SSOE:

131447777 131455627(raph1b)

HHIP:

117754573 117777398(raph1b)

HSP:	118103146 118119756

PPLT:

128430821(raph1b) 128456125(raph1a)

SMAU:

118282655(raph1a) 118301331(raph1b)

LCF:	108872960(raph1b) 108897033

SDU:	111218060 111238733

SLAL:

111644467 111645838 111654078

XGL:	120798026(raph1b) 120801756(raph1a)

HCQ:	109520015 109520917

SSCV:

125973233(raph1a) 125988590(raph1b)

SBIA:

133492001(raph1b) 133511856(raph1a)

PEE:	133410352(raph1a) 133410729(raph1b)

PTAO:

133487098(raph1a) 133489789(raph1b)

BPEC:

110168982 110170608

ENY:	140359816(raph1a) 140362324(raph1b)

MALB:

109955723(raph1) 109972675

BSPL:

114847103(raph1a) 114870120(raph1b)

SJO:	128354106(raph1b) 128368407(raph1a)

SSCO:

133976476(raph1b) 133993343(raph1a)

GMH:	115542027 115561277

SASA:

106574363 106575142 106582537 106582538 106586946 106586965 106591902

STRU:

115161444 115179787 115195125

OTW:	112246890 112255195 112267737(raph1b)

OMY:	110496785 110502196 110520666 110527565

OGO:	124007721 124044307

ONE:	115129623 115144677

OKI:	109870778 109877725 109890450 109906664

OKE:	118363988 118369972 118380362 118382252(raph1a)

OMM:	135528936 135541666 135543605

OCLA:

139372281 139380994 139400131 139405540 139405561 139412569

SALP:

111953338 111971112 112076874

SNH:	120033176 120051227(raph1b) 120058160

CCLU:

121537106 121554390 121563788

ELS:	105009980(raph1) 105023746

OEP:	134017308(raph1a)

SFM:	108918342(raph1) 108920638

PKI:	111840730 111858346

AANG:

118222958(raph1a)

AROT:

135241241 135251743(raph1a)

CCOG:

133116677 133124054(raph1a)

LOC:	102687652(raph1)

PSPA:

121322122 121323054

ARUT:

117412909 117426827

PSEX:

120531946

LCM:	102352045(RAPH1)

CMK:	103176835(raph1a)

CPLA:

122551375(raph1a)

HOC:	132817228(raph1a)

LERI:

129698960(raph1a)

PMRN:

116943806 116945129

LRJ:	133344958 133355509(RAPH1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115918244 592651

LPIC:

AJJ:

APLC:

AAMU:

AFIL:

SKO:

DME:	Dmel_CG11940(pico)

DER:

6550457

DSE:

6615065

DSI:	Dsimw501_GD15562(Dsim_GD15562)

DYA:	Dyak_GE17351

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15244

DAZ:

108618194

DNV:

108656378

DHE:

111598282

DVI:	6636132(pico)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135956761(pico)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002888

CPII:

CBRI:

CNS:

BCOO:

AME:

ACER:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

DPA:	109538666 125503804

ESIM:

136412247(pico)

EFOR:

136341314(pico)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209666

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

BPHI:

137932942(pico)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110374223(picO)

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

LGLY:

CSTB:

CCRN:

API:

DNX:

RMD:

BTAB:

DCI:

NLU:

MQU:

PHU:	Phum_PHUM397090

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138712464(pico)

BROR:

134531738

IEL:

124164524

HAMR:

139696217(pico)

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128694180(pico)

PTRU:

123516193

MNZ:

135226382

MRJ:

136832072

PORN:

139759957(pico)

HAZT:

108668866

EAF:	111696679 111697772

LSM:	121127389 121129003 121129638

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

CSCU:

CVS:	136984438(pico)

PTEP:

107436524 107449707

ABRU:

129956695 129963026

UDV:

129216143

SDM:	118187817 118203258

CEL:	CELE_F10E9.6(mig-10)

CBR:	CBG_16642(Cbr-mig-10)

CRQ:	GCK72_009796

TSP:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

OSN:

LAK:

SMM:	Smp_150170 Smp_156390

NVE:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

Reference

PMID:11586298

Authors

Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE.

Title

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.

Journal

Nat Genet 29:166-73 (2001)
DOI:10.1038/ng1001-166

Sequence

[hsa:65059]

LinkDB

DBGET integrated database retrieval system