KEGG   MODULE: M00774
Entry
M00774            Pathway   Module                                 
Name
Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Definition
K10817+K24563+K24564 K14366 K14367 K14368+K15997 K14370 K14369
Diagram
M00774

Orthology
eryA; 6-deoxyerythronolide-B synthase [EC:2.3.1.94] [RN:R00918]
K14366  
eryF; 6-deoxyerythronolide B hydroxylase [EC:1.14.15.35] [RN:R05270]
K14367  
eryBV; erythronolide mycarosyltransferase [EC:2.4.1.328] [RN:R05530]
K14368  
eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278] [RN:R05531]
K15997  
eryCII; 3-alpha-mycarosylerythronolide B desosaminyl transferase auxiliary protein [RN:R05531]
K14370  
eryK; erythromycin 12 hydroxylase [EC:1.14.13.154] [RN:R05522]
K14369  
eryG; erythromycin 3''-O-methyltransferase [EC:2.1.1.254] [RN:R05520 R05532]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Macrolide biosynthesis
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00100  Propanoyl-CoA
C00683  (S)-Methylmalonyl-CoA
C03240  6-Deoxyerythronolide B
C06635  Erythronolide B
C06630  3-O-alpha-Mycarosylerythronolide B
C06633  Erythromycin D
C06616  Erythromycin C
C01912  Erythromycin
C06653  Erythromycin B
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