KEGG   PATHWAY: aang00480
Entry
aang00480                   Pathway                                
Name
Glutathione metabolism - Anguilla anguilla (European eel)
Class
Metabolism; Metabolism of other amino acids
Pathway map
aang00480  Glutathione metabolism
aang00480

Module
aang_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:aang00480]
Other DBs
GO: 0006749
Organism
Anguilla anguilla (European eel) [GN:aang]
Gene
118224589  glutathione hydrolase-like YwrD proenzyme isoform X1 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
118206325  si:ch73-337l15.2; glutathione hydrolase 6 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
118207276  glutathione hydrolase 7 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
118206561  ggt1a; gamma-glutamyltransferase 1a isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118213101  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118213102  ggt5b; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118212318  ggctb; gamma-glutamylcyclotransferase b [KO:K00682] [EC:4.3.2.9]
118234751  ggcta; gamma-glutamylcyclotransferase a [KO:K00682] [EC:4.3.2.9]
118229633  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
118223262  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
118221160  chac2; putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
118218194  gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
118225395  gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]
118216157  glutathione synthetase-like isoform X1 [KO:K21456] [EC:6.3.2.3]
118207913  gss; glutathione synthetase isoform X1 [KO:K21456] [EC:6.3.2.3]
118226919  lap3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
118206469  zgc:152830; putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
118215612  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
118215613  anpepb; alanyl (membrane) aminopeptidase b [KO:K11140] [EC:3.4.11.2]
118227838  aminopeptidase Ey-like [KO:K11140] [EC:3.4.11.2]
118227839  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
118217612  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
118218686  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118231768  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118206843  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
118212792  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
118207796  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
118207797  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118233362  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118233364  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118213628  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
118237188  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
118228221  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
118229068  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
118224049  lancl1; glutathione S-transferase LANCL1 [KO:K25210] [EC:2.5.1.18]
118210912  probable N-acetyltransferase CML5 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
118231241  N-acetyltransferase 8-like [KO:K20838] [EC:2.3.1.80 2.3.1.-]
118227525  N-acetyltransferase family 8 member 3-like [KO:K20838] [EC:2.3.1.80 2.3.1.-]
118231736  gsr; glutathione reductase, mitochondrial isoform X1 [KO:K00383] [EC:1.8.1.7]
118222787  idh1; isocitrate dehydrogenase [NADP] cytoplasmic isoform X1 [KO:K00031] [EC:1.1.1.42]
118214316  isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
118208681  pgd; 6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
118211240  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
118207828  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
118228783  txndc12; thioredoxin domain-containing protein 12 [KO:K05360] [EC:1.8.4.2]
118230010  gpx4b; phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K05361] [EC:1.11.1.12]
118224614  gpx4a; glutathione peroxidase 4a [KO:K05361] [EC:1.11.1.12]
118211156  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
118225497  gpx7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
118207559  gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
118208198  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
118221531  gpx9; glutathione peroxidase 9 [KO:K00432] [EC:1.11.1.9]
118237218  gpx8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
118225679  prdx6; peroxiredoxin-6 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
118212076  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
118231992  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
118225739  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
118234221  ornithine decarboxylase-like isoform X1 [KO:K01581] [EC:4.1.1.17]
118208166  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
118235458  sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
118236069  rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
118230138  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
118234113  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
118221731  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
aang00220  Arginine biosynthesis
aang00250  Alanine, aspartate and glutamate metabolism
aang00270  Cysteine and methionine metabolism
aang00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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