KEGG   PATHWAY: alca00760
Entry
alca00760                   Pathway                                
Name
Nicotinate and nicotinamide metabolism - Alcanivorax sp. ALC70
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
alca00760  Nicotinate and nicotinamide metabolism
alca00760

Module
alca_M00115  NAD biosynthesis, aspartate => quinolinate => NAD [PATH:alca00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Alcanivorax sp. ALC70 [GN:alca]
Gene
ASALC70_00046  [KO:K01081] [EC:3.1.3.5]
ASALC70_00118  nicB_1; Nicotinate dehydrogenase subunit B [KO:K18030] [EC:1.17.2.1]
ASALC70_00119  nicA; Nicotinate dehydrogenase subunit A [KO:K18029] [EC:1.17.2.1]
ASALC70_00120  nicB_2; Nicotinate dehydrogenase subunit B [KO:K18030] [EC:1.17.2.1]
ASALC70_00125  nicC; 6-hydroxynicotinate 3-monooxygenase [KO:K14974] [EC:1.14.13.114]
ASALC70_00126  nicD_1; N-formylmaleamate deformylase [KO:K15357] [EC:3.5.1.106]
ASALC70_00127  maiA_1; Maleate isomerase [KO:K01799] [EC:5.2.1.1]
ASALC70_00128  nicF_1; Maleamate amidohydrolase [KO:K13995] [EC:3.5.1.107]
ASALC70_00168  pntAA; NAD(P) transhydrogenase subunit alpha part 1 [KO:K00324] [EC:7.1.1.1]
ASALC70_00169  pntA; NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]
ASALC70_00170  pntB; NAD(P) transhydrogenase subunit beta [KO:K00325] [EC:7.1.1.1]
ASALC70_00193  nudC_2; NADH pyrophosphatase [KO:K03426] [EC:3.6.1.22]
ASALC70_00301  cobB; NAD-dependent protein deacylase [KO:K12410] [EC:2.3.1.286 2.3.1.313]
ASALC70_00440  sthA; Soluble pyridine nucleotide transhydrogenase [KO:K00322] [EC:1.6.1.1]
ASALC70_00711  pncC; Nicotinamide-nucleotide amidohydrolase PncC [KO:K03743] [EC:3.5.1.42]
ASALC70_00841  nadA; Quinolinate synthase A [KO:K03517] [EC:2.5.1.72]
ASALC70_00914  yfkN; Trifunctional nucleotide phosphoesterase protein YfkN [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ASALC70_00934  gabD; Succinate-semialdehyde dehydrogenase [NADP(+)] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
ASALC70_01119  nadC_1; Nicotinate-nucleotide pyrophosphorylase [carboxylating] [KO:K00767] [EC:2.4.2.19]
ASALC70_01294  davD; Glutarate-semialdehyde dehydrogenase DavD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
ASALC70_01391  nadE; Glutamine-dependent NAD(+) synthetase [KO:K01950] [EC:6.3.5.1]
ASALC70_03044  [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ASALC70_03084  nicF_2; Maleamate amidohydrolase [KO:K13995] [EC:3.5.1.107]
ASALC70_03085  maiA_2; Maleate isomerase [KO:K01799] [EC:5.2.1.1]
ASALC70_03087  nicD_2; N-formylmaleamate deformylase [KO:K15357] [EC:3.5.1.106]
ASALC70_03156  pncB2; Nicotinate phosphoribosyltransferase pncB2 [KO:K00763] [EC:6.3.4.21]
ASALC70_03362  nadD; Nicotinate-nucleotide adenylyltransferase [KO:K00969] [EC:2.7.7.18]
ASALC70_03810  nadB; L-aspartate oxidase [KO:K00278] [EC:1.4.3.16]
ASALC70_03833  mazG_2; Nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
ASALC70_03936  ald_1; 3-succinoylsemialdehyde-pyridine dehydrogenase [KO:K19700] [EC:1.2.1.83]
ASALC70_03973  surE; 5'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ASALC70_04044  nadK; NAD kinase [KO:K00858] [EC:2.7.1.23]
ASALC70_04410  nicF_3; Maleamate amidohydrolase [KO:K13995] [EC:3.5.1.107]
ASALC70_04411  nicD_3; N-formylmaleamate deformylase [KO:K15357] [EC:3.5.1.106]
ASALC70_04412  maiA_4; Maleate isomerase [KO:K01799] [EC:5.2.1.1]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
alca00020  Citrate cycle (TCA cycle)
alca00250  Alanine, aspartate and glutamate metabolism
alca00380  Tryptophan metabolism
alca00620  Pyruvate metabolism
alca00660  C5-Branched dibasic acid metabolism
KO pathway
ko00760   

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