KEGG   PATHWAY: amd00230
Entry
amd00230                    Pathway                                
Name
Purine metabolism - Amycolatopsis mediterranei U32
Class
Metabolism; Nucleotide metabolism
Pathway map
amd00230  Purine metabolism
amd00230

Module
amd_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:amd00230]
amd_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:amd00230]
amd_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:amd00230]
amd_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:amd00230]
amd_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:amd00230]
amd_M00546  Purine degradation, xanthine => urea [PATH:amd00230]
amd_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:amd00230]
amd_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:amd00230]
Other DBs
GO: 0006163 0042278
Organism
Amycolatopsis mediterranei U32 [GN:amd]
Gene
AMED_0082  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
AMED_0267  [KO:K01768] [EC:4.6.1.1]
AMED_0461  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
AMED_0700  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
AMED_0771  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
AMED_0773  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
AMED_0782  guaA; GMP synthase (glutamine-hydrolysing) [KO:K01951] [EC:6.3.5.2]
AMED_0806  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
AMED_0807  purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
AMED_0862  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
AMED_0908  punA; purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
AMED_0992  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
AMED_0993  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
AMED_1571  [KO:K01768] [EC:4.6.1.1]
AMED_1926  [KO:K00365] [EC:1.7.3.3]
AMED_1927  [KO:K07127] [EC:3.5.2.17]
AMED_1928  [KO:K16840] [EC:4.1.1.97]
AMED_1930  allB; L-hydantoinase/allantoinase [KO:K01466] [EC:3.5.2.5]
AMED_1931  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
AMED_2147  [KO:K03651] [EC:3.1.4.53]
AMED_2184  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
AMED_2190  [KO:K00856] [EC:2.7.1.20]
AMED_2394  nrdA; ribonucleoside-diphosphate reductase alpha chain [KO:K00525] [EC:1.17.4.1]
AMED_2755  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
AMED_2845  cysC; adenylylsulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
AMED_2846  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
AMED_2858  dgt; dGTPase [KO:K01129] [EC:3.1.5.1]
AMED_2878  nrdB; ribonucleoside-diphosphate reductase beta chain [KO:K00526] [EC:1.17.4.1]
AMED_2879  nrdA; ribonucleoside-diphosphate reductase alpha chain [KO:K00525] [EC:1.17.4.1]
AMED_2956  yfiH; multi-copper oxidoreductase [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
AMED_2977  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
AMED_3002  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
AMED_3039  [KO:K11177] [EC:1.17.1.4]
AMED_3040  [KO:K11178] [EC:1.17.1.4]
AMED_3353  [KO:K07816] [EC:2.7.6.5]
AMED_3446  surE; stationary phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
AMED_3641  [KO:K11177] [EC:1.17.1.4]
AMED_3642  [KO:K11178] [EC:1.17.1.4]
AMED_3643  [KO:K13483]
AMED_3719  [KO:K11177] [EC:1.17.1.4]
AMED_3722  [KO:K13483]
AMED_4586  guaD; deaminase [KO:K01487] [EC:3.5.4.3]
AMED_4670  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
AMED_4748  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
AMED_5294  relA; GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
AMED_5295  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
AMED_5326  [KO:K19710] [EC:2.7.7.53]
AMED_5757  [KO:K11178] [EC:1.17.1.4]
AMED_6018  [KO:K16841] [EC:5.1.99.3]
AMED_6598  dgt; dGTPase [KO:K01129] [EC:3.1.5.1]
AMED_6659  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
AMED_6660  cysN; sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
AMED_6714  ndk; nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
AMED_7357  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
AMED_7703  [KO:K01519] [EC:3.6.1.66]
AMED_7816  surE; stationary phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
AMED_8071  guaB; IMP dehydrogenase [KO:K26110]
AMED_8196  ppx; Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
AMED_8235  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
AMED_8448  ureC; urease alpha subunit [KO:K01428] [EC:3.5.1.5]
AMED_8449  ureB; urease beta subunit [KO:K01429] [EC:3.5.1.5]
AMED_8450  ureA; urease gamma subunit [KO:K01430] [EC:3.5.1.5]
AMED_8493  nrdB; ribonucleoside-diphosphate reductase beta chain [KO:K00526] [EC:1.17.4.1]
AMED_8509  nagD; NagD protein [KO:K02566] [EC:3.1.3.5]
AMED_8753  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
AMED_9034  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
AMED_9035  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
AMED_9047  purL; phosphoribosylformylglycinamidine synthase [KO:K23269]
AMED_9050  purL; phosphoribosylformylglycinamidine synthase [KO:K23265]
AMED_9051  purL; phosphoribosylformylglycinamidine synthase [KO:K23264]
AMED_9060  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
AMED_9067  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
AMED_9086  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
AMED_9098  purA; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
AMED_9190  [KO:K01081] [EC:3.1.3.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
amd00030  Pentose phosphate pathway
amd00220  Arginine biosynthesis
amd00250  Alanine, aspartate and glutamate metabolism
amd00260  Glycine, serine and threonine metabolism
amd00340  Histidine metabolism
amd00630  Glyoxylate and dicarboxylate metabolism
amd00730  Thiamine metabolism
amd00740  Riboflavin metabolism
amd00790  Folate biosynthesis
KO pathway
ko00230   

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