KEGG   PATHWAY: amye00260
Entry
amye00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Amycolatopsis sp. EV170708-02-1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
amye00260  Glycine, serine and threonine metabolism
amye00260

Module
amye_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:amye00260]
amye_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:amye00260]
amye_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:amye00260]
amye_M00555  Betaine biosynthesis, choline => betaine [PATH:amye00260]
amye_M00621  Glycine cleavage system [PATH:amye00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Amycolatopsis sp. EV170708-02-1 [GN:amye]
Gene
MJQ72_00155  [KO:K00274] [EC:1.4.3.4]
MJQ72_00490  [KO:K01697] [EC:4.2.1.22]
MJQ72_03460  [KO:K00273] [EC:1.4.3.3]
MJQ72_03745  [KO:K00130] [EC:1.2.1.8]
MJQ72_03770  [KO:K00130] [EC:1.2.1.8]
MJQ72_03780  [KO:K17755] [EC:1.1.3.17]
MJQ72_08010  [KO:K00928] [EC:2.7.2.4]
MJQ72_08020  [KO:K00836] [EC:2.6.1.76]
MJQ72_08195  [KO:K01754] [EC:4.3.1.19]
MJQ72_09650  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MJQ72_09680  gcvH; glycine cleavage system protein GcvH [KO:K02437]
MJQ72_10360  [KO:K00276] [EC:1.4.3.21]
MJQ72_11265  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
MJQ72_11855  [KO:K00600] [EC:2.1.2.1]
MJQ72_12210  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MJQ72_12695  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
MJQ72_12700  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
MJQ72_12705  [KO:K06720] [EC:4.2.1.108]
MJQ72_12710  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
MJQ72_12775  [KO:K01754] [EC:4.3.1.19]
MJQ72_12890  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MJQ72_13420  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
MJQ72_14975  [KO:K01697] [EC:4.2.1.22]
MJQ72_15580  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
MJQ72_15585  [KO:K00309]
MJQ72_16730  [KO:K00003] [EC:1.1.1.3]
MJQ72_16735  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MJQ72_16740  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
MJQ72_17100  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
MJQ72_17190  [KO:K25316]
MJQ72_18100  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
MJQ72_18400  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MJQ72_19615  [KO:K13745] [EC:4.1.1.86]
MJQ72_22990  [KO:K00639] [EC:2.3.1.29]
MJQ72_22995  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
MJQ72_25520  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
MJQ72_27425  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
MJQ72_27430  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
MJQ72_28060  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MJQ72_29375  [KO:K01754] [EC:4.3.1.19]
MJQ72_29490  [KO:K00865] [EC:2.7.1.165]
MJQ72_29635  [KO:K01752] [EC:4.3.1.17]
MJQ72_29645  [KO:K00600] [EC:2.1.2.1]
MJQ72_29650  gcvH; glycine cleavage system protein GcvH [KO:K02437]
MJQ72_29655  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
MJQ72_29660  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MJQ72_30970  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MJQ72_31645  [KO:K13745] [EC:4.1.1.86]
MJQ72_31975  [KO:K16066] [EC:1.1.1.381 1.1.1.-]
MJQ72_32140  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MJQ72_32410  [KO:K06001] [EC:4.2.1.20]
MJQ72_32730  [KO:K00865] [EC:2.7.1.165]
MJQ72_35450  [KO:K00130] [EC:1.2.1.8]
MJQ72_36745  [KO:K01834] [EC:5.4.2.11]
MJQ72_39350  [KO:K01834] [EC:5.4.2.11]
MJQ72_43410  [KO:K01620] [EC:4.1.2.48]
MJQ72_44030  [KO:K01754] [EC:4.3.1.19]
MJQ72_44230  [KO:K00928] [EC:2.7.2.4]
MJQ72_44235  [KO:K00133] [EC:1.2.1.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
amye00010  Glycolysis / Gluconeogenesis
amye00020  Citrate cycle (TCA cycle)
amye00230  Purine metabolism
amye00250  Alanine, aspartate and glutamate metabolism
amye00270  Cysteine and methionine metabolism
amye00290  Valine, leucine and isoleucine biosynthesis
amye00300  Lysine biosynthesis
amye00330  Arginine and proline metabolism
amye00460  Cyanoamino acid metabolism
amye00470  D-Amino acid metabolism
amye00564  Glycerophospholipid metabolism
amye00600  Sphingolipid metabolism
amye00620  Pyruvate metabolism
amye00630  Glyoxylate and dicarboxylate metabolism
amye00640  Propanoate metabolism
amye00680  Methane metabolism
amye00860  Porphyrin metabolism
amye00920  Sulfur metabolism
KO pathway
ko00260   

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