KEGG   PATHWAY: asd00260
Entry
asd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Hoyosella subflava
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
asd00260  Glycine, serine and threonine metabolism
asd00260

Module
asd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:asd00260]
asd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:asd00260]
asd_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:asd00260]
asd_M00555  Betaine biosynthesis, choline => betaine [PATH:asd00260]
asd_M00621  Glycine cleavage system [PATH:asd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Hoyosella subflava [GN:asd]
Gene
AS9A_0234  Aspartokinase [KO:K00928] [EC:2.7.2.4]
AS9A_0235  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AS9A_3271  thrA; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AS9A_3269  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
AS9A_3270  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
AS9A_1001  glyA1; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AS9A_3260  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AS9A_3407  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AS9A_1358  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
AS9A_0627  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AS9A_3192  serA2; Phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AS9A_2883  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AS9A_0851  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AS9A_3636  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AS9A_3682  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AS9A_2292  Amine oxidase [KO:K00274] [EC:1.4.3.4]
AS9A_3135  gcvP; Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AS9A_1265  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
AS9A_0593  dldH1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AS9A_4223  dldH2; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AS9A_3140  gcvH; Glycine cleavage system H protein [KO:K02437]
AS9A_0996  Glycine cleavage system H protein [KO:K02437]
AS9A_0564  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AS9A_2469  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AS9A_2470  Aldehyde dehydrogenase (Acceptor) [KO:K00130] [EC:1.2.1.8]
AS9A_2718  Aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AS9A_1005  Dimethylglycine oxidase [KO:K00309] [EC:1.5.3.10]
AS9A_0968  Putative dehydrogenase [KO:K00309] [EC:1.5.3.10]
AS9A_3013  Putative sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
AS9A_2250  Putative sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
AS9A_0998  soxA; Sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AS9A_1000  soxB; Sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AS9A_0997  soxG; Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AS9A_0999  soxD; Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AS9A_3444  Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AS9A_0995  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
AS9A_1379  ilvA; Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AS9A_1457  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
AS9A_1456  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
AS9A_1132  ectB; Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
AS9A_1133  ectA; putative L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
AS9A_1131  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
AS9A_2077  ectD; Ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
asd00010  Glycolysis / Gluconeogenesis
asd00020  Citrate cycle (TCA cycle)
asd00230  Purine metabolism
asd00250  Alanine, aspartate and glutamate metabolism
asd00270  Cysteine and methionine metabolism
asd00290  Valine, leucine and isoleucine biosynthesis
asd00300  Lysine biosynthesis
asd00330  Arginine and proline metabolism
asd00460  Cyanoamino acid metabolism
asd00470  D-Amino acid metabolism
asd00564  Glycerophospholipid metabolism
asd00600  Sphingolipid metabolism
asd00620  Pyruvate metabolism
asd00630  Glyoxylate and dicarboxylate metabolism
asd00640  Propanoate metabolism
asd00680  Methane metabolism
asd00860  Porphyrin metabolism
asd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system