KEGG   PATHWAY: axx00260
Entry
axx00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Achromobacter xylosoxidans NCTC10807
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
axx00260  Glycine, serine and threonine metabolism
axx00260

Module
axx_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:axx00260]
axx_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:axx00260]
axx_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:axx00260]
axx_M00621  Glycine cleavage system [PATH:axx00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Achromobacter xylosoxidans NCTC10807 [GN:axx]
Gene
ERS451415_00018  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
ERS451415_00031  ghrA_1; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ERS451415_00412  ltaE_1; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
ERS451415_00488  serA_2; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ERS451415_00682  glyA2; Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
ERS451415_00770  ghrA_2; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ERS451415_00872  glxK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
ERS451415_01161  cbs; Putative cystathionine beta-synthase Rv1077 [KO:K01697] [EC:4.2.1.22]
ERS451415_01281  [KO:K17103] [EC:2.7.8.8]
ERS451415_01286  tdcB_2; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
ERS451415_01388  serB_2; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ERS451415_01435  trpB_1; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
ERS451415_01436  trpA_1; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ERS451415_01466  thrC_1; Threonine synthase [KO:K01733] [EC:4.2.3.1]
ERS451415_01487  ltaE_2; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
ERS451415_01546  lpd_1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ERS451415_01605  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
ERS451415_01694  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
ERS451415_01776  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ERS451415_01777  thrC_2; Threonine synthase [KO:K01733] [EC:4.2.3.1]
ERS451415_01954  ectA; L-2%2C4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
ERS451415_01955  ectB; Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
ERS451415_01956  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
ERS451415_01957  [KO:K10674] [EC:1.14.11.55]
ERS451415_02008  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
ERS451415_02031  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ERS451415_02209  ghrB_1; Glyoxylate/hydroxypyruvate reductase B [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ERS451415_02355  lpdV; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ERS451415_02402  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ERS451415_02635  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ERS451415_02646  serB_3; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ERS451415_02960  ilvA_1; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
ERS451415_03641  trpA_2; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ERS451415_03642  trpB_2; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
ERS451415_04005  serA_3; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ERS451415_04430  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
ERS451415_04839  [KO:K15634] [EC:5.4.2.11]
ERS451415_05088  thrC_3; Threonine synthase [KO:K01733] [EC:4.2.3.1]
ERS451415_05240  hprA_2; Glycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ERS451415_05418  gcvP; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
ERS451415_05419  gcvH; Glycine cleavage system H protein [KO:K02437]
ERS451415_05420  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ERS451415_05627  lpd_2; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ERS451415_05840  gpmA; 2%2C3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
ERS451415_05877  ilvA_3; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
axx00010  Glycolysis / Gluconeogenesis
axx00020  Citrate cycle (TCA cycle)
axx00230  Purine metabolism
axx00250  Alanine, aspartate and glutamate metabolism
axx00270  Cysteine and methionine metabolism
axx00290  Valine, leucine and isoleucine biosynthesis
axx00300  Lysine biosynthesis
axx00330  Arginine and proline metabolism
axx00460  Cyanoamino acid metabolism
axx00470  D-Amino acid metabolism
axx00564  Glycerophospholipid metabolism
axx00620  Pyruvate metabolism
axx00630  Glyoxylate and dicarboxylate metabolism
axx00640  Propanoate metabolism
axx00680  Methane metabolism
axx00860  Porphyrin metabolism
axx00920  Sulfur metabolism
KO pathway
ko00260   

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