KEGG   PATHWAY: bbub00564
Entry
bbub00564                   Pathway                                
Name
Glycerophospholipid metabolism - Bubalus bubalis (water buffalo)
Class
Metabolism; Lipid metabolism
Pathway map
bbub00564  Glycerophospholipid metabolism
bbub00564

Module
bbub_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:bbub00564]
bbub_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:bbub00564]
bbub_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:bbub00564]
Other DBs
GO: 0006650
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102389230  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
102389697  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
102389740  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102389799  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
102389829  [KO:K01047] [EC:3.1.1.4]
102390273  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102391966  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102392030  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
102392536  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102392762  DGKD; diacylglycerol kinase delta isoform X3 [KO:K00901] [EC:2.7.1.107]
102392834  DGKB; diacylglycerol kinase beta isoform X6 [KO:K00901] [EC:2.7.1.107]
102392844  SAMD8; sphingomyelin synthase-related protein 1 isoform X3 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
102392874  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
102393874  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
102393976  MBOAT1; lysophospholipid acyltransferase 1 isoform X3 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
102394128  DGKH; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
102394165  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
102394253  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
102394576  LCAT; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
102394798  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
102394935  ACHE; acetylcholinesterase isoform X6 [KO:K01049] [EC:3.1.1.7]
102395827  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
102395955  LYPLA2; acyl-protein thioesterase 2 isoform X2 [KO:K06130] [EC:3.1.1.5]
102396041  PLA2G1B; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
102396275  LPIN3; phosphatidate phosphatase LPIN3 isoform X2 [KO:K15728] [EC:3.1.3.4]
102396534  [KO:K00006] [EC:1.1.1.8]
102396601  PLD4; 5'-3' exonuclease PLD4 isoform X1 [KO:K16860] [EC:3.1.4.4]
102396804  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
102397023  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
102397173  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
102397181  LPCAT4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
102397236  CHKB; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
102397314  PLB1; phospholipase B1, membrane-associated isoform X2 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
102397348  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
102397889  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102398203  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
102398511  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
102398595  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
102398810  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X2 [KO:K00629] [EC:2.3.1.15]
102398827  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
102398843  [KO:K16342] [EC:3.1.1.4]
102398973  PCYT1B; choline-phosphate cytidylyltransferase B isoform X2 [KO:K00968] [EC:2.7.7.15]
102399428  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
102399488  TAFAZZIN; tafazzin isoform X6 [KO:K13511] [EC:2.3.1.-]
102399738  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
102400071  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
102400403  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102400416  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102400714  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102400731  [KO:K01047] [EC:3.1.1.4]
102400941  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
102401066  PLA2G5; phospholipase A2 group V isoform X1 [KO:K01047] [EC:3.1.1.4]
102401164  MBOAT7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
102401375  MBOAT2; lysophospholipid acyltransferase 2 isoform X2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
102401383  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
102401542  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
102401814  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
102401857  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
102402038  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
102402212  [KO:K01047] [EC:3.1.1.4]
102402444  [KO:K01047] [EC:3.1.1.4]
102402530  [KO:K01047] [EC:3.1.1.4]
102402859  PLA2G2E; LOW QUALITY PROTEIN: group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102402999  [KO:K01047] [EC:3.1.1.4]
102403166  CHKA; choline kinase alpha isoform X3 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
102403270  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X4 [KO:K00967] [EC:2.7.7.14]
102403304  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X4 [KO:K01613] [EC:4.1.1.65]
102403424  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
102403763  PLA1A; phospholipase A1 member A isoform X2 [KO:K13618] [EC:3.1.1.111]
102404075  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
102404499  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
102404689  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X2 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
102404879  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
102404907  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
102406386  DGKZ; diacylglycerol kinase zeta isoform X9 [KO:K00901] [EC:2.7.1.107]
102406534  CRLS1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
102406782  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
102407495  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102407501  LPIN1; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
102407527  [KO:K00993] [EC:2.7.8.1]
102407729  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
102408133  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
102408396  [KO:K13510] [EC:2.3.1.23 2.3.1.67]
102408701  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
102409556  [KO:K01080] [EC:3.1.3.4]
102409796  PLPP3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
102409892  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
102410149  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
102410417  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X3 [KO:K06124] [EC:3.1.3.75]
102410554  PLPP5; phospholipid phosphatase 5 isoform X4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
102411091  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X4 [KO:K14676] [EC:3.1.1.5]
102411131  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
102411175  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
102411282  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
102411630  DGKI; diacylglycerol kinase iota isoform X7 [KO:K00901] [EC:2.7.1.107]
102411882  DGKQ; diacylglycerol kinase theta isoform X3 [KO:K00901] [EC:2.7.1.107]
102413487  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
102413504  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X3 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
102414164  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X15 [KO:K14676] [EC:3.1.1.5]
102414958  PLD1; phospholipase D1 isoform X5 [KO:K01115] [EC:3.1.4.4]
102415155  PEMT; phosphatidylethanolamine N-methyltransferase isoform X2 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
102415191  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [KO:K13514] [EC:2.3.1.-]
102415571  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
102415591  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
102416409  PLA2G12A; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
102416465  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
112585204  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123332249  [KO:K01047] [EC:3.1.1.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
bbub00010  Glycolysis / Gluconeogenesis
bbub00260  Glycine, serine and threonine metabolism
bbub00561  Glycerolipid metabolism
bbub00562  Inositol phosphate metabolism
bbub00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
bbub00565  Ether lipid metabolism
bbub00620  Pyruvate metabolism
KO pathway
ko00564   

DBGET integrated database retrieval system