KEGG   PATHWAY: bhz00260
Entry
bhz00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bordetella hinzii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bhz00260  Glycine, serine and threonine metabolism
bhz00260

Module
bhz_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bhz00260]
bhz_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bhz00260]
bhz_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:bhz00260]
bhz_M00621  Glycine cleavage system [PATH:bhz00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bordetella hinzii [GN:bhz]
Gene
ACR54_01226  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
ACR54_01808  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ACR54_02918  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ACR54_01792  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
ACR54_02917  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
ACR54_03271  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
ACR54_00474  glyA2_1; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
ACR54_04068  glyA2_2; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
ACR54_00894  Soluble hydrogenase 42 kDa subunit [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
ACR54_01166  ghrA_2; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ACR54_00659  ghrA_1; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ACR54_02962  ghrA_3; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ACR54_03852  glxK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
ACR54_00297  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
ACR54_01581  pspA; Phosphoserine phosphatase 1 [KO:K15634] [EC:5.4.2.11]
ACR54_01474  slcC_2; (S)-sulfolactate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ACR54_02478  hprA; Glycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ACR54_04229  serA_1; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ACR54_03087  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
ACR54_00454  serB_1; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ACR54_03366  serB_2; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ACR54_00698  gcvP; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
ACR54_00696  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ACR54_03708  lpd_2; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ACR54_02184  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ACR54_03216  lpd_1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ACR54_02709  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ACR54_00697  gcvH; Glycine cleavage system H protein [KO:K02437]
ACR54_01085  CDP-alcohol phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
ACR54_01612  phdK_1; 2-formylbenzoate dehydrogenase [KO:K00130] [EC:1.2.1.8]
ACR54_02253  phdK_2; 2-formylbenzoate dehydrogenase [KO:K00130] [EC:1.2.1.8]
ACR54_03486  tdcG; L-serine dehydratase TdcG [KO:K01752] [EC:4.3.1.17]
ACR54_01095  tdcB_1; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
ACR54_04238  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
ACR54_01049  D-threonine aldolase [KO:K01753] [EC:4.3.1.18]
ACR54_03315  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ACR54_03316  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
ACR54_03470  ectB; Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
ACR54_03471  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
ACR54_03469  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
ACR54_03468  Phytanoyl-CoA dioxygenase (PhyH) [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bhz00010  Glycolysis / Gluconeogenesis
bhz00020  Citrate cycle (TCA cycle)
bhz00230  Purine metabolism
bhz00250  Alanine, aspartate and glutamate metabolism
bhz00270  Cysteine and methionine metabolism
bhz00290  Valine, leucine and isoleucine biosynthesis
bhz00300  Lysine biosynthesis
bhz00330  Arginine and proline metabolism
bhz00460  Cyanoamino acid metabolism
bhz00470  D-Amino acid metabolism
bhz00564  Glycerophospholipid metabolism
bhz00620  Pyruvate metabolism
bhz00630  Glyoxylate and dicarboxylate metabolism
bhz00640  Propanoate metabolism
bhz00680  Methane metabolism
bhz00860  Porphyrin metabolism
bhz00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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