KEGG   PATHWAY: bmb00230
Entry
bmb00230                    Pathway                                
Name
Purine metabolism - Brucella abortus bv. 1 9-941
Class
Metabolism; Nucleotide metabolism
Pathway map
bmb00230  Purine metabolism
bmb00230

Module
bmb_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bmb00230]
bmb_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:bmb00230]
bmb_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:bmb00230]
bmb_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:bmb00230]
bmb_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:bmb00230]
bmb_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:bmb00230]
bmb_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:bmb00230]
Other DBs
GO: 0006163 0042278
Organism
Brucella abortus bv. 1 9-941 [GN:bmb]
Gene
BruAb1_0058  pgm; Pgm, phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
BruAb1_1522  prsA; PrsA, ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
BruAb1_0468  purF; PurF, amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
BruAb1_0437  purD; PurD, phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
BruAb1_0728  purN; PurN, phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
BruAb1_0850  purL; PurL, phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
BruAb1_0854  conserved hypothetical protein TIGR00302 [KO:K23264] [EC:6.3.5.3]
BruAb1_0853  purQ; PurQ, phosphoribosylformylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
BruAb1_0729  purM; PurM, phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
BruAb1_1730  purK; PurK, phosphoribosylaminoimidazole carboxylase, ATPase subunit [KO:K01589] [EC:6.3.4.18]
BruAb1_1729  purE; PurE, phosphoribosylaminoimidazole carboxylase, catalytic subunit [KO:K01588] [EC:5.4.99.18]
BruAb1_0855  purC; PurC, phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
BruAb1_0861  purB; PurB, adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
BruAb1_1796  purH; PurH, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
BruAb1_1529  apt; Apt, adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
BruAb1_0898  surE; SurE, stationary-phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
BruAb1_1519  conserved hypothetical protein TIGR00726 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
BruAb1_1961  hpt; Hpt, hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
BruAb2_0830  guaB; inosine-5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
BruAb1_0713  ndk; Ndk, nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
BruAb1_0171  ham1 protein [KO:K01519] [EC:3.6.1.66]
BruAb1_0375  xanthine dehydrogenase, hypothetical [KO:K13481] [EC:1.17.1.4]
BruAb1_0376  xanthine dehydrogenase [KO:K13482] [EC:1.17.1.4]
BruAb2_0821  guaA; GuaA, GMP synthase [KO:K01951] [EC:6.3.5.2]
BruAb1_0380  chlorohydrolase family protein [KO:K01487] [EC:3.5.4.3]
BruAb1_0486  gmk; Gmk, guanylate kinase [KO:K00942] [EC:2.7.4.8]
BruAb1_1048  ribonucleotide reductase domain protein [KO:K00525] [EC:1.17.4.1]
BruAb2_0865  nrdE; NrdE, ribonucleoside-diphosphate reductase, alpha subunit [KO:K00525] [EC:1.17.4.1]
BruAb2_0864  nrdF; NrdF, ribonucleoside-diphosphate reductase, beta subunit [KO:K00526] [EC:1.17.4.1]
BruAb1_0888  dgt; Dgt, deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
BruAb1_0683  conserved hypothetical protein [KO:K06952] [EC:3.1.3.89]
BruAb1_0669  RelA/SpoT family protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
BruAb1_0766  phosphatase, Ppx/GppA family [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BruAb2_0544  phosphatase, Ppx/GppA family [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BruAb1_1668  purA; PurA, adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
BruAb1_0642  amn; Amn, AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
BruAb2_0573  ade; Ade, adenine deaminase [KO:K01486] [EC:3.5.4.2]
BruAb1_1707  conserved hypothetical protein TIGR00282 [KO:K09769] [EC:3.1.4.16]
BruAb1_1217  adk; Adk, adenylate kinase [KO:K00939] [EC:2.7.4.3]
BruAb1_0741  adenylate kinase, hypothetical [KO:K00939] [EC:2.7.4.3]
BruAb1_1072  mazG family protein [KO:K04765] [EC:3.6.1.9]
BruAb1_0189  cysNC; CysNC, sulfate adenylate transferase, subunit 1/adenylylsulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
BruAb1_0188  cysD; CysD, sulfate adenylate transferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
BruAb1_0530  conserved hypothetical protein [KO:K07127] [EC:3.5.2.17]
BruAb1_0373  conserved hypothetical protein [KO:K16842] [EC:3.5.2.5]
BruAb1_0372  conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
BruAb1_0529  ureidoglycolate hydrolase, hypothetical [KO:K01483] [EC:4.3.2.3]
BruAb1_0296  ureC-1; UreC-1, urease, alpha subunit [KO:K01428] [EC:3.5.1.5]
BruAb1_1355  ureC-2; UreC-2, urease, alpha subunit [KO:K01428] [EC:3.5.1.5]
BruAb1_0295  ureB-1; UreB-1, urease, beta subunit [KO:K01429] [EC:3.5.1.5]
BruAb1_1354  ureB-2; UreB-2, urease, beta subunit [KO:K01429] [EC:3.5.1.5]
BruAb1_0294  ureA-1; UreA-1, urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
BruAb1_1353  ureA-2; UreA-2, urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
bmb00030  Pentose phosphate pathway
bmb00220  Arginine biosynthesis
bmb00250  Alanine, aspartate and glutamate metabolism
bmb00260  Glycine, serine and threonine metabolism
bmb00340  Histidine metabolism
bmb00630  Glyoxylate and dicarboxylate metabolism
bmb00730  Thiamine metabolism
bmb00740  Riboflavin metabolism
bmb00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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