KEGG   PATHWAY: bmec00260
Entry
bmec00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia metallica
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bmec00260  Glycine, serine and threonine metabolism
bmec00260

Module
bmec_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bmec00260]
bmec_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bmec00260]
bmec_M00555  Betaine biosynthesis, choline => betaine [PATH:bmec00260]
bmec_M00621  Glycine cleavage system [PATH:bmec00260]
bmec_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bmec00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia metallica [GN:bmec]
Gene
WJ16_10690  aspartate kinase [KO:K00928] [EC:2.7.2.4]
WJ16_23870  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
WJ16_09500  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
WJ16_23455  homoserine kinase [KO:K02204] [EC:2.7.1.39]
WJ16_09495  threonine synthase [KO:K01733] [EC:4.2.3.1]
WJ16_31710  threonine aldolase [KO:K01620] [EC:4.1.2.48]
WJ16_03655  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
WJ16_17640  hypothetical protein [KO:K00600] [EC:2.1.2.1]
WJ16_29965  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
WJ16_08510  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
WJ16_15020  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
WJ16_26355  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
WJ16_08820  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
WJ16_05170  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
WJ16_09865  glycerate kinase [KO:K00865] [EC:2.7.1.165]
WJ16_14550  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
WJ16_03040  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
WJ16_18615  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
WJ16_27330  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
WJ16_15885  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
WJ16_04855  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
WJ16_09125  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
WJ16_03650  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
WJ16_19850  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
WJ16_19855  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
WJ16_28370  amine oxidase [KO:K00274] [EC:1.4.3.4]
WJ16_28380  amine oxidase [KO:K00274] [EC:1.4.3.4]
WJ16_00715  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
WJ16_00725  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
WJ16_05855  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
WJ16_07305  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
WJ16_11010  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
WJ16_00720  glycine cleavage system protein H [KO:K02437]
WJ16_11755  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
WJ16_30050  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
WJ16_30045  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
WJ16_21165  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
WJ16_29930  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
WJ16_29925  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
WJ16_29950  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
WJ16_29945  (Fe-S)-binding protein [KO:K21834]
WJ16_29940  electron transfer flavoprotein subunit alpha [KO:K25960]
WJ16_29935  drug:proton antiporter [KO:K25961]
WJ16_30405  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
WJ16_30415  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
WJ16_30400  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
WJ16_30410  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
WJ16_00705  serine dehydratase [KO:K01752] [EC:4.3.1.17]
WJ16_30420  serine dehydratase [KO:K01752] [EC:4.3.1.17]
WJ16_09975  pyridoxal-5'-phosphate-dependent protein subunit beta [KO:K01754] [EC:4.3.1.19]
WJ16_14035  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
WJ16_05950  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
WJ16_14060  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
WJ16_11050  aspartate racemase [KO:K25316] [EC:5.1.1.10]
WJ16_23910  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
WJ16_23900  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
WJ16_27485  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
WJ16_19685  hypothetical protein [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bmec00010  Glycolysis / Gluconeogenesis
bmec00020  Citrate cycle (TCA cycle)
bmec00230  Purine metabolism
bmec00250  Alanine, aspartate and glutamate metabolism
bmec00270  Cysteine and methionine metabolism
bmec00290  Valine, leucine and isoleucine biosynthesis
bmec00300  Lysine biosynthesis
bmec00330  Arginine and proline metabolism
bmec00460  Cyanoamino acid metabolism
bmec00470  D-Amino acid metabolism
bmec00564  Glycerophospholipid metabolism
bmec00600  Sphingolipid metabolism
bmec00620  Pyruvate metabolism
bmec00630  Glyoxylate and dicarboxylate metabolism
bmec00640  Propanoate metabolism
bmec00680  Methane metabolism
bmec00860  Porphyrin metabolism
bmec00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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