KEGG PATHWAY: bmk00260

PATHWAY: bmk00260

Entry

bmk00260                    Pathway

Name

Glycine, serine and threonine metabolism - Burkholderia multivorans DDS 15A-1

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

bmk00260

Glycine, serine and threonine metabolism

Module

bmk_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bmk00260]

bmk_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:bmk00260]

bmk_M00555

Betaine biosynthesis, choline => betaine [PATH:bmk00260]

bmk_M00621

Glycine cleavage system [PATH:bmk00260]

bmk_M00919

Ectoine degradation, ectoine => aspartate [PATH:bmk00260]

bmk_M00975

Betaine degradation, bacteria, betaine => pyruvate [PATH:bmk00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Burkholderia multivorans DDS 15A-1 [GN:bmk]

Gene

DM80_149

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

DM80_1549

gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]

DM80_1550

gcvH; glycine cleavage system H protein [KO:K02437]

DM80_1551

gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

DM80_1553

[KO:K01752] [EC:4.3.1.17]

DM80_1776

[KO:K00058] [EC:1.1.1.95 1.1.1.399]

DM80_1965

[KO:K12972] [EC:1.1.1.79 1.1.1.81]

DM80_2060

gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

DM80_2179

ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]

DM80_2703

pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

DM80_2824

[KO:K25316]

DM80_2832

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

DM80_2898

[KO:K00928] [EC:2.7.2.4]

DM80_3026

psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]

DM80_3096

[KO:K00865] [EC:2.7.1.165]

DM80_3172

[KO:K00003] [EC:1.1.1.3]

DM80_3173

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

DM80_3245

serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]

DM80_3281

ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

DM80_3823

trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]

DM80_3825

trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]

DM80_3829

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

DM80_3904

[KO:K00058] [EC:1.1.1.95 1.1.1.399]

DM80_4000

[KO:K00130] [EC:1.2.1.8]

DM80_4049

thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]

DM80_4389

[KO:K00130] [EC:1.2.1.8]

DM80_4480

amadh1; aminoaldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]

DM80_4533

tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]

DM80_4534

kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]

DM80_4691

ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

DM80_4894

[KO:K01752] [EC:4.3.1.17]

DM80_4895

[KO:K00303] [EC:1.5.3.24 1.5.3.1]

DM80_4896

soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]

DM80_4897

[KO:K00302] [EC:1.5.3.24 1.5.3.1]

DM80_4898

[KO:K00305] [EC:1.5.3.24 1.5.3.1]

DM80_4925

betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

DM80_4926

betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]

DM80_4935

glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]

DM80_4938

[KO:K21833] [EC:1.5.7.3]

DM80_4939

[KO:K21834]

DM80_4940

[KO:K25960]

DM80_4941

[KO:K25961]

DM80_4942

[KO:K00479] [EC:1.14.13.251]

DM80_4943

[KO:K21832] [EC:1.14.13.251]

DM80_537

[KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

DM80_5394

ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]

DM80_5436

[KO:K00058] [EC:1.1.1.95 1.1.1.399]

DM80_601

serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]

DM80_6595

[KO:K15785] [EC:2.6.1.76]

DM80_6596

[KO:K15786] [EC:1.2.1.-]

DM80_6598

eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]

DM80_6599

eutD; ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]

DM80_6601

eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]

DM80_883

[KO:K00600] [EC:2.1.2.1]

DM80_884

ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]

DM80_986

[KO:K15634] [EC:5.4.2.11]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

C23135

(2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate

C23136

4-Amino-L-allothreonine

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721