KEGG   PATHWAY: bmul00260
Entry
bmul00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia multivorans ATCC BAA-247
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bmul00260  Glycine, serine and threonine metabolism
bmul00260

Module
bmul_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bmul00260]
bmul_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bmul00260]
bmul_M00555  Betaine biosynthesis, choline => betaine [PATH:bmul00260]
bmul_M00621  Glycine cleavage system [PATH:bmul00260]
bmul_M00919  Ectoine degradation, ectoine => aspartate [PATH:bmul00260]
bmul_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bmul00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia multivorans ATCC BAA-247 [GN:bmul]
Gene
NP80_2136  aspartate kinase domain protein [KO:K00928] [EC:2.7.2.4]
NP80_3942  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NP80_1914  ACT domain protein [KO:K00003] [EC:1.1.1.3]
NP80_3833  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
NP80_1913  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
NP80_3231  beta-eliminating lyase family protein [KO:K01620] [EC:4.1.2.48]
NP80_4991  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
NP80_3241  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
NP80_818  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
NP80_3081  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NP80_1806  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
NP80_1206  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
NP80_1990  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
NP80_2973  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
NP80_720  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
NP80_4829  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NP80_56  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NP80_1143  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
NP80_1842  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
NP80_817  short chain dehydrogenase family protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NP80_3397  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
NP80_3398  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
NP80_269  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NP80_271  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
NP80_2253  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NP80_4655  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
NP80_1589  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NP80_270  gcvH; glycine cleavage system H protein [KO:K02437]
NP80_2382  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
NP80_5001  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
NP80_3536  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
NP80_5000  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NP80_3234  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
NP80_4984  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
NP80_3233  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
NP80_4983  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
NP80_4988  flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
NP80_4987  4Fe-4S dicluster domain protein [KO:K21834]
NP80_4986  electron transfer flavoFAD-binding domain protein [KO:K25960]
NP80_4985  electron transfer flavodomain protein [KO:K25961]
NP80_5029  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
NP80_5031  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
NP80_5028  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
NP80_5030  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
NP80_267  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
NP80_5032  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
NP80_5362  eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
NP80_2011  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
NP80_2870  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
NP80_2875  putative D-serine deaminase (D-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
NP80_2262  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
NP80_3948  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
NP80_3946  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
NP80_4525  ectoine synthase family protein [KO:K06720] [EC:4.2.1.108]
NP80_5360  eutD; ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]
NP80_5359  eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
NP80_5356  aminotransferase class-III family protein [KO:K15785] [EC:2.6.1.76]
NP80_5357  aldehyde dehydrogenase family protein [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bmul00010  Glycolysis / Gluconeogenesis
bmul00020  Citrate cycle (TCA cycle)
bmul00230  Purine metabolism
bmul00250  Alanine, aspartate and glutamate metabolism
bmul00270  Cysteine and methionine metabolism
bmul00290  Valine, leucine and isoleucine biosynthesis
bmul00300  Lysine biosynthesis
bmul00330  Arginine and proline metabolism
bmul00460  Cyanoamino acid metabolism
bmul00470  D-Amino acid metabolism
bmul00564  Glycerophospholipid metabolism
bmul00620  Pyruvate metabolism
bmul00630  Glyoxylate and dicarboxylate metabolism
bmul00640  Propanoate metabolism
bmul00680  Methane metabolism
bmul00860  Porphyrin metabolism
bmul00920  Sulfur metabolism
KO pathway
ko00260   
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