KEGG   PATHWAY: bpsh00260
Entry
bpsh00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia pseudomallei HBPUB10134a
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bpsh00260  Glycine, serine and threonine metabolism
bpsh00260

Module
bpsh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bpsh00260]
bpsh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bpsh00260]
bpsh_M00555  Betaine biosynthesis, choline => betaine [PATH:bpsh00260]
bpsh_M00621  Glycine cleavage system [PATH:bpsh00260]
bpsh_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bpsh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia pseudomallei HBPUB10134a [GN:bpsh]
Gene
DR55_1141  [KO:K01752] [EC:4.3.1.17]
DR55_1143  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
DR55_1144  gcvH; glycine cleavage system H protein [KO:K02437]
DR55_1145  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
DR55_1615  [KO:K15634] [EC:5.4.2.11]
DR55_1759  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
DR55_1760  [KO:K00600] [EC:2.1.2.1]
DR55_1991  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
DR55_2057  [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
DR55_2222  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR55_2340  [KO:K00928] [EC:2.7.2.4]
DR55_2361  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
DR55_2484  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
DR55_2512  [KO:K00865] [EC:2.7.1.165]
DR55_2593  [KO:K00003] [EC:1.1.1.3]
DR55_2594  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
DR55_2658  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DR55_2693  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
DR55_2806  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DR55_3015  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR55_3352  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DR55_3409  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DR55_3484  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
DR55_3566  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DR55_3570  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
DR55_3572  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
DR55_3635  [KO:K00836] [EC:2.6.1.76]
DR55_3906  [KO:K01752] [EC:4.3.1.17]
DR55_3907  [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DR55_3908  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DR55_3909  [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DR55_3910  [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DR55_3924  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
DR55_3925  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DR55_4006  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DR55_460  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DR55_4796  [KO:K21832] [EC:1.14.13.251]
DR55_4797  [KO:K00479] [EC:1.14.13.251]
DR55_4798  [KO:K25961]
DR55_4799  [KO:K25960]
DR55_4800  [KO:K21834]
DR55_4801  [KO:K21833] [EC:1.5.7.3]
DR55_4804  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
DR55_5121  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DR55_5238  [KO:K00865] [EC:2.7.1.165]
DR55_5365  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
DR55_5366  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
DR55_5460  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR55_5614  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
DR55_604  [KO:K00836] [EC:2.6.1.76]
DR55_638  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DR55_751  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DR55_929  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bpsh00010  Glycolysis / Gluconeogenesis
bpsh00020  Citrate cycle (TCA cycle)
bpsh00230  Purine metabolism
bpsh00250  Alanine, aspartate and glutamate metabolism
bpsh00270  Cysteine and methionine metabolism
bpsh00290  Valine, leucine and isoleucine biosynthesis
bpsh00300  Lysine biosynthesis
bpsh00330  Arginine and proline metabolism
bpsh00460  Cyanoamino acid metabolism
bpsh00470  D-Amino acid metabolism
bpsh00564  Glycerophospholipid metabolism
bpsh00600  Sphingolipid metabolism
bpsh00620  Pyruvate metabolism
bpsh00630  Glyoxylate and dicarboxylate metabolism
bpsh00640  Propanoate metabolism
bpsh00680  Methane metabolism
bpsh00860  Porphyrin metabolism
bpsh00920  Sulfur metabolism
KO pathway
ko00260   

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