Entry Name Wnt signaling pathway - Betta splendens (Siamese fighting fish)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Betta splendens (Siamese fighting fish) [GN:
bspl ]
Gene 114841850 camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114841916 camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114842948 wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408 ]
114843331 nkd2b; protein naked cuticle homolog 2-like isoform X1 [KO:K03213 ]
114843874 chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494 ] [EC:5.6.2.-]
114844625 tbl1xr1b; F-box-like/WD repeat-containing protein TBL1XR1b isoform X1 [KO:K04508 ]
114844972 nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
114846581 plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
114848018 daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
114850734 dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
114851748 lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309 ]
114851943 tle3b; transducin-like enhancer protein 3-B isoform X10 [KO:K04497 ]
114852780 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
114853080 apc2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085 ]
114853453 tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508 ]
114854201 tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497 ]
114854621 sox17; LOW QUALITY PROTEIN: transcription factor SOX-17 [KO:K04495 ]
114856083 wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572 ]
114857201 tle3a; transducin-like enhancer protein 3-A isoform X1 [KO:K04497 ]
114857281 nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
114857895 lrp5; low-density lipoprotein receptor-related protein 5 isoform X2 [KO:K03068 ]
114858502 prickle3; prickle planar cell polarity protein 3 isoform X2 [KO:K04511 ]
114858594 ppardb; peroxisome proliferator-activated receptor delta b isoform X1 [KO:K04504 ]
114859080 nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
114859359 rhoab; rho-related GTP-binding protein RhoA-B isoform X1 [KO:K04513 ]
114861092 prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345 ] [EC:2.7.11.11 ]
114861283 lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
114861619 rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
114861770 camk2b1; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 [KO:K04515 ] [EC:2.7.11.17 ]
114864179 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114865037 fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362 ]
114865467 smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
114865898 nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
114866304 camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114867319 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
114869288 serpinf1; pigment epithelium-derived factor isoform X1 [KO:K19614 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
