KEGG   PATHWAY: cic00260
Entry
cic00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Citrus x clementina (clementine)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cic00260  Glycine, serine and threonine metabolism
cic00260

Module
cic_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cic00260]
cic_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cic00260]
cic_M00555  Betaine biosynthesis, choline => betaine [PATH:cic00260]
cic_M00621  Glycine cleavage system [PATH:cic00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Citrus x clementina (clementine) [GN:cic]
Gene
CICLE_v10014778mg  hypothetical protein [KO:K00928] [EC:2.7.2.4]
CICLE_v10023926mg  hypothetical protein [KO:K12524] [EC:2.7.2.4 1.1.1.3]
CICLE_v10018756mg  hypothetical protein [KO:K12524] [EC:2.7.2.4 1.1.1.3]
CICLE_v10015633mg  hypothetical protein [KO:K00133] [EC:1.2.1.11]
CICLE_v10028700mg  hypothetical protein [KO:K00872] [EC:2.7.1.39]
CICLE_v10008029mg  hypothetical protein [KO:K01733] [EC:4.2.3.1]
CICLE_v10025353mg  hypothetical protein [KO:K01733] [EC:4.2.3.1]
CICLE_v10020798mg  hypothetical protein [KO:K01620] [EC:4.1.2.48]
CICLE_v10025372mg  hypothetical protein [KO:K00600] [EC:2.1.2.1]
CICLE_v10000656mg  hypothetical protein [KO:K00600] [EC:2.1.2.1]
CICLE_v10000875mg  hypothetical protein [KO:K00600] [EC:2.1.2.1]
CICLE_v10004902mg  hypothetical protein [KO:K00600] [EC:2.1.2.1]
CICLE_v10019689mg  hypothetical protein [KO:K00600] [EC:2.1.2.1]
CICLE_v10015490mg  hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CICLE_v10028639mg  hypothetical protein [KO:K15893] [EC:1.1.1.29]
CICLE_v10024328mg  hypothetical protein [KO:K15919] [EC:1.1.1.79 1.1.1.81]
CICLE_v10026120mg  hypothetical protein [KO:K15919] [EC:1.1.1.79 1.1.1.81]
CICLE_v10021082mg  hypothetical protein [KO:K15919] [EC:1.1.1.79 1.1.1.81]
CICLE_v10027051mg  hypothetical protein [KO:K01834] [EC:5.4.2.11]
CICLE_v10001708mg  hypothetical protein [KO:K01834] [EC:5.4.2.11]
CICLE_v10026175mg  hypothetical protein [KO:K15634] [EC:5.4.2.11]
CICLE_v10011402mg  hypothetical protein [KO:K15633] [EC:5.4.2.12]
CICLE_v10025569mg  hypothetical protein [KO:K15918] [EC:2.7.1.31]
CICLE_v10028055mg  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CICLE_v10000651mg  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CICLE_v10025148mg  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CICLE_v10025659mg  hypothetical protein [KO:K00831] [EC:2.6.1.52]
CICLE_v10021430mg  hypothetical protein [KO:K01079] [EC:3.1.3.3]
CICLE_v10004484mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10006614mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10018950mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10019032mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10030749mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10004473mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10004511mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10006554mg  hypothetical protein [KO:K00276] [EC:1.4.3.21]
CICLE_v10007310mg  hypothetical protein [KO:K00281] [EC:1.4.4.2]
CICLE_v10015433mg  hypothetical protein [KO:K00605] [EC:2.1.2.10]
CICLE_v10004547mg  hypothetical protein [KO:K00382] [EC:1.8.1.4]
CICLE_v10004793mg  hypothetical protein [KO:K00382] [EC:1.8.1.4]
CICLE_v10032942mg  hypothetical protein [KO:K02437]
CICLE_v10017047mg  hypothetical protein [KO:K02437]
CICLE_v10025514mg  hypothetical protein [KO:K00827] [EC:2.6.1.44 2.6.1.40]
CICLE_v10011621mg  hypothetical protein [KO:K00827] [EC:2.6.1.44 2.6.1.40]
CICLE_v10031381mg  hypothetical protein [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
CICLE_v10008481mg  hypothetical protein [KO:K00499] [EC:1.14.15.7]
CICLE_v10019800mg  hypothetical protein [KO:K00130] [EC:1.2.1.8]
CICLE_v10025411mg  hypothetical protein [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
CICLE_v10008463mg  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CICLE_v10008459mg  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CICLE_v10011319mg  hypothetical protein [KO:K01754] [EC:4.3.1.19]
CICLE_v10021870mg  hypothetical protein [KO:K12235] [EC:5.1.1.18]
CICLE_v10002141mg  hypothetical protein [KO:K01695] [EC:4.2.1.20]
CICLE_v10021275mg  hypothetical protein [KO:K01695] [EC:4.2.1.20]
CICLE_v10008204mg  hypothetical protein [KO:K01696] [EC:4.2.1.20]
CICLE_v10015207mg  hypothetical protein [KO:K01696] [EC:4.2.1.20]
CICLE_v10011534mg  hypothetical protein [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cic00010  Glycolysis / Gluconeogenesis
cic00020  Citrate cycle (TCA cycle)
cic00230  Purine metabolism
cic00250  Alanine, aspartate and glutamate metabolism
cic00270  Cysteine and methionine metabolism
cic00290  Valine, leucine and isoleucine biosynthesis
cic00300  Lysine biosynthesis
cic00330  Arginine and proline metabolism
cic00460  Cyanoamino acid metabolism
cic00470  D-Amino acid metabolism
cic00564  Glycerophospholipid metabolism
cic00600  Sphingolipid metabolism
cic00620  Pyruvate metabolism
cic00630  Glyoxylate and dicarboxylate metabolism
cic00640  Propanoate metabolism
cic00860  Porphyrin metabolism
cic00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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