KEGG   PATHWAY: cimi03013
Entry
cimi03013                   Pathway                                
Name
Nucleocytoplasmic transport - Cebus imitator (Panamanian white-faced capuchin)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
cimi03013  Nucleocytoplasmic transport
cimi03013

Other DBs
GO: 0050658
Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108311466  aladin-like [KO:K14320]
108284860  AAAS; aladin [KO:K14320]
108303212  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
108318156  GLE1; nucleoporin GLE1 [KO:K18723]
108294380  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
108294384  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
108309957  RAE1; mRNA export factor [KO:K14298]
108307506  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
108282987  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
108297769  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
108312957  RANBP2; E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
108290504  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
108290898  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
108311790  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
108281349  small ubiquitin-related modifier 5 [KO:K12160]
108309407  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
108281886  small ubiquitin-related modifier 2-like [KO:K12160]
108287393  SUMO4; LOW QUALITY PROTEIN: small ubiquitin-related modifier 4 [KO:K12160]
108295609  small ubiquitin-related modifier 3-like [KO:K12160]
108311283  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
108301877  small ubiquitin-related modifier 2-like [KO:K12160]
108305128  small ubiquitin-related modifier 2-like [KO:K12160]
108308187  small ubiquitin-related modifier 2-like [KO:K12160]
108284088  small ubiquitin-related modifier 2 [KO:K12160]
108293375  small ubiquitin-related modifier 2 [KO:K12160]
108295967  small ubiquitin-related modifier 1-like [KO:K12160]
108295971  small ubiquitin-related modifier 1 [KO:K12160]
108318403  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
108309408  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
108284658  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
108300141  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
108302766  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
108282480  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
108287380  NUP43; nucleoporin Nup43 [KO:K14305]
108294825  NUP37; nucleoporin Nup37 [KO:K14302]
108306870  AHCTF1; protein ELYS [KO:K25129]
108292016  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
108316539  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
108310489  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
108293431  NUP54; nucleoporin p54 isoform X2 [KO:K14308]
108307217  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
108283028  NUP188; nucleoporin NUP188 homolog [KO:K14311]
108317615  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
108285477  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
108307374  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
108286530  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
108292497  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
108286907  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
108307911  nuclear envelope pore membrane protein POM 121C [KO:K14316]
108297825  POM121L2; POM121-like protein 2 [KO:K14316]
108315551  TMEM33; transmembrane protein 33 [KO:K20724]
108301376  TPR; nucleoprotein TPR [KO:K09291]
108304987  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
108298923  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
108311099  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
108288951  KPNA1; importin subunit alpha-5 [KO:K23940]
108307883  KPNA7; importin subunit alpha-8 [KO:K15043]
108314115  KPNA2; importin subunit alpha-1 [KO:K15043]
108313702  importin subunit alpha-1-like [KO:K15043]
108309516  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
108310334  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
108281650  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
108303936  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
108281547  KPNB1; importin subunit beta-1 [KO:K14293]
108303690  TNPO1; transportin-1 isoform X1 [KO:K18752]
108282047  TNPO2; transportin-2 isoform X1 [KO:K18727]
108318477  TNPO3; transportin-3 isoform X1 [KO:K15436]
108315372  IPO4; importin-4 isoform X1 [KO:K20221]
108305403  IPO5; importin-5 [KO:K20222]
108283810  IPO7; importin-7 [KO:K20223]
108293734  IPO8; importin-8 isoform X1 [KO:K18755]
108283222  IPO9; importin-9 isoform X1 [KO:K20224]
108317870  IPO11; importin-11 isoform X1 [KO:K25201]
108312708  IPO13; importin-13 isoform X1 [KO:K25202]
108317481  snurportin-1 [KO:K13151]
108315593  XPO1; exportin-1 [KO:K14290]
108313080  CSE1L; exportin-2 isoform X1 [KO:K18423]
108288400  XPOT; exportin-T [KO:K14288]
108317569  XPO4; exportin-4 isoform X1 [KO:K25203]
108317133  XPO5; exportin-5 [KO:K14289]
108302218  XPO6; exportin-6 isoform X1 [KO:K25204]
108312021  XPO7; exportin-7 isoform X1 [KO:K18460]
108317323  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
108303766  GTP-binding nuclear protein Ran-like [KO:K07936]
108286585  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
108309481  putative elongation factor 1-alpha-like 3 [KO:K03231]
108310991  putative elongation factor 1-alpha-like 3 [KO:K03231]
108301242  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
108298539  elongation factor 1-alpha 1-like [KO:K03231]
108298597  elongation factor 1-alpha 1-like [KO:K03231]
108299025  elongation factor 1-alpha 1-like [KO:K03231]
108301269  elongation factor 1-alpha 1-like [KO:K03231]
108301277  elongation factor 1-alpha 1-like [KO:K03231]
108292927  putative elongation factor 1-alpha-like 3 isoform X2 [KO:K03231]
108293995  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
108284321  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
108303899  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
119473852  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
108310322  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
108291449  RNA-binding protein 8A-like [KO:K12876]
108293671  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
108317305  protein mago nashi homolog [KO:K12877]
108286522  MAGOH; protein mago nashi homolog [KO:K12877]
108295845  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
108281512  CASC3; protein CASC3 [KO:K14323]
108301714  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
108315267  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
108292979  histone deacetylase complex subunit SAP18 [KO:K14324]
108317603  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
108290919  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
108306091  PNN; pinin [KO:K13114]
108293233  THO complex subunit 4-like [KO:K12881]
108301653  ALYREF; THO complex subunit 4 [KO:K12881]
108284566  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
108305186  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
108291041  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
108296312  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
108297537  nuclear RNA export factor 2-like [KO:K14284]
108286198  NXF1; nuclear RNA export factor 1 [KO:K14284]
108295756  nuclear RNA export factor 2-like [KO:K14284]
108295772  NXF3; nuclear RNA export factor 3 isoform X1 [KO:K14284]
108313163  NXT1; NTF2-related export protein 1 [KO:K14285]
108316557  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
108299862  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
108308674  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
108296808  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
108282924  THOC1; THO complex subunit 1 [KO:K12878]
108281828  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
108283350  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
108290975  THOC6; THO complex subunit 6 homolog isoform X2 [KO:K13175]
108303513  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
108296131  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
cimi03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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