KEGG   PATHWAY: csed00260
Entry
csed00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Citrobacter sedlakii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
csed00260  Glycine, serine and threonine metabolism
csed00260

Module
csed_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:csed00260]
csed_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:csed00260]
csed_M00555  Betaine biosynthesis, choline => betaine [PATH:csed00260]
csed_M00621  Glycine cleavage system [PATH:csed00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Citrobacter sedlakii [GN:csed]
Gene
JY391_00115  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
JY391_00620  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
JY391_00625  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
JY391_00645  gpmM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
JY391_00880  ghrB; glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
JY391_01315  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
JY391_01710  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
JY391_03160  garK; glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
JY391_03175  tdcB; bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB [KO:K01754] [EC:4.3.1.19]
JY391_03195  tdcG; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
JY391_03725  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
JY391_03755  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
JY391_03820  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
JY391_03825  gcvH; glycine cleavage system protein GcvH [KO:K02437]
JY391_03830  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
JY391_04280  [KO:K25316]
JY391_04515  sdaB; L-serine ammonia-lyase II [KO:K01752] [EC:4.3.1.17]
JY391_04570  [KO:K00865] [EC:2.7.1.165]
JY391_05715  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
JY391_06295  [KO:K00600] [EC:2.1.2.1]
JY391_09505  ghrA; glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
JY391_10295  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
JY391_10300  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
JY391_11460  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
JY391_12970  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
JY391_13670  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
JY391_13890  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
JY391_14610  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
JY391_15505  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
JY391_15510  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
JY391_17750  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
JY391_18300  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
JY391_18305  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
JY391_18310  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
JY391_18360  gpmB; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
JY391_20935  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
JY391_21370  metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
JY391_22175  [KO:K00865] [EC:2.7.1.165]
JY391_22195  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
C23135  (2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate
C23136  4-Amino-L-allothreonine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
csed00010  Glycolysis / Gluconeogenesis
csed00020  Citrate cycle (TCA cycle)
csed00230  Purine metabolism
csed00250  Alanine, aspartate and glutamate metabolism
csed00270  Cysteine and methionine metabolism
csed00290  Valine, leucine and isoleucine biosynthesis
csed00300  Lysine biosynthesis
csed00330  Arginine and proline metabolism
csed00460  Cyanoamino acid metabolism
csed00470  D-Amino acid metabolism
csed00564  Glycerophospholipid metabolism
csed00600  Sphingolipid metabolism
csed00620  Pyruvate metabolism
csed00630  Glyoxylate and dicarboxylate metabolism
csed00640  Propanoate metabolism
csed00680  Methane metabolism
csed00860  Porphyrin metabolism
csed00920  Sulfur metabolism
KO pathway
ko00260   

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