KEGG   PATHWAY: csum03013
Entry
csum03013                   Pathway                                
Name
Nucleocytoplasmic transport - Capricornis sumatraensis (Sumatran serow)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
csum03013  Nucleocytoplasmic transport
csum03013

Other DBs
GO: 0050658
Organism
Capricornis sumatraensis (Sumatran serow) [GN:csum]
Gene
138070806  THOC2; THO complex subunit 2 [KO:K12879]
138070893  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
138071066  [KO:K14284]
138071073  [KO:K14284]
138071088  [KO:K07936]
138071108  [KO:K14284]
138071109  [KO:K14284]
138071115  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
138071466  NXT2; NTF2-related export protein 2 [KO:K14285]
138072692  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
138072887  IPO13; importin-13 [KO:K25202]
138073084  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
138073447  [KO:K12160]
138073453  [KO:K12160]
138073454  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
138073464  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
138073547  MAGOH; protein mago nashi homolog [KO:K12877]
138073808  THOC3; THO complex subunit 3 [KO:K12880]
138074028  IPO4; importin-4 isoform X1 [KO:K20221]
138074048  NUP188; nucleoporin NUP188 [KO:K14311]
138075365  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
138075414  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
138075501  XPO6; exportin-6 isoform X1 [KO:K25204]
138075610  THOC6; THO complex subunit 6 isoform X1 [KO:K13175]
138075638  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
138075668  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
138075786  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
138076108  NUP35; nucleoporin NUP35 [KO:K14313]
138076758  [KO:K12879]
138076901  KPNA7; importin subunit alpha-8 [KO:K15043]
138077186  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
138077212  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
138077576  GLE1; mRNA export factor GLE1 isoform X1 [KO:K18723]
138077592  XPOT; exportin-T [KO:K14288]
138077905  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
138077923  AAAS; aladin isoform X1 [KO:K14320]
138078004  IPO8; importin-8 [KO:K18755]
138078025  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
138078118  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
138078251  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
138078378  [KO:K12877]
138078675  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
138079048  PYM1; partner of Y14 and mago [KO:K14294]
138079168  NUP37; nucleoporin Nup37 [KO:K14302]
138079958  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
138080083  SUMO3; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
138080178  TNPO3; transportin-3 isoform X1 [KO:K15436]
138080243  NUP42; nucleoporin NUP42 [KO:K14321]
138080445  [KO:K14285]
138080763  XPO7; exportin-7 [KO:K18460]
138081354  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
138081709  TMEM33; transmembrane protein 33 [KO:K20724]
138082007  NUP54; nucleoporin p54 [KO:K14308]
138082127  XPO1; exportin-1 isoform X1 [KO:K14290]
138082817  KPNB1; importin subunit beta-1 [KO:K14293]
138082973  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
138083019  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
138083062  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
138083246  KPNA2; importin subunit alpha-1 [KO:K15043]
138083325  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
138083363  CASC3; protein CASC3 [KO:K14323]
138084050  [KO:K03231]
138084126  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
138084372  ALYREF; THO complex subunit 4 [KO:K12881]
138084542  [KO:K12160]
138085335  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
138085566  [KO:K14325]
138085730  [KO:K12172] [EC:2.3.2.-]
138085889  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
138086544  [KO:K14325]
138086608  TNPO2; transportin-2 [KO:K18727]
138086898  [KO:K07936]
138087203  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
138087225  SEC13; protein SEC13 homolog [KO:K14004]
138087357  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
138087392  THOC7; THO complex subunit 7 isoform X1 [KO:K13176]
138088725  [KO:K14285]
138089064  XPO4; exportin-4 isoform X1 [KO:K25203]
138089073  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
138089103  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
138089163  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
138089315  IPO5; importin-5 [KO:K20222]
138089349  KPNA3; importin subunit alpha-4 [KO:K23583]
138089724  KPNA5; importin subunit alpha-6 [KO:K15042]
138089789  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
138089870  NUP43; nucleoporin Nup43 [KO:K14305]
138089888  [KO:K12160]
138090610  TPR; nucleoprotein TPR [KO:K09291]
138090780  IPO9; importin-9 [KO:K20224]
138090857  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
138090868  AHCTF1; protein ELYS isoform X1 [KO:K25129]
138091063  CSE1L; exportin-2 [KO:K18423]
138091103  KPNA4; importin subunit alpha-3 [KO:K23583]
138091289  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
138091376  RAE1; mRNA export factor RAE1 [KO:K14298]
138091629  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
138091689  NXT1; NTF2-related export protein 1 [KO:K14285]
138092603  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
138092748  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
138093219  IPO7; importin-7 [KO:K20223]
138093642  RAN; GTP-binding nuclear protein Ran [KO:K07936]
138094134  THOC5; THO complex subunit 5 isoform X1 [KO:K13174]
138094344  TNPO1; transportin-1 [KO:K18752]
138094347  IPO11; importin-11 [KO:K25201]
138094417  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
138094722  RANBP17; ran-binding protein 17 [KO:K24115]
138094923  PNN; pinin [KO:K13114]
138095394  SNUPN; snurportin-1 [KO:K13151]
138095948  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
138095980  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
138096436  [KO:K18655] [EC:5.6.2.7]
138096483  [KO:K12160]
138096500  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
138097676  THOC1; THO complex subunit 1 [KO:K12878]
138097838  XPO5; exportin-5 [KO:K14289]
138097856  POM121L2; POM121-like protein 2 [KO:K14316]
138097962  NUP210L; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210-like [KO:K14314]
138098026  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
138098071  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
csum03015  mRNA surveillance pathway
KO pathway
ko03013   

DBGET integrated database retrieval system