PATHWAY: dre00860 Help
Entry Name Porphyrin metabolism - Danio rerio (zebrafish)
Description Porphyrins are a group of chemical compounds with the backbone ring structure consisting of four linked pyrrole units. Metal complexes of porphyrins, as well as those of corrinoids with the one-carbon shorter ring structure, play important biological roles. They include iron-containing heme, magnesium-containing chlorophyll, nickel-containing coenzyme F430 and cobalt-containing cobamide (such as vitamin B12 coenzyme) as shown in this map.
Class Metabolism; Metabolism of cofactors and vitaminsBRITE hierarchy
Pathway map Module Other DBs Organism Danio rerio (zebrafish) [GN:
dre ]
Gene 321294 cpoX; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [KO:K00228 ] [EC:1.3.3.3 ]
322378 ugt5a3; UDP glucuronosyltransferase 5 family, polypeptide A3 precursor [KO:K00699 ] [EC:2.4.1.17 ]
556049 ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 isoform X1 [KO:K00699 ] [EC:2.4.1.17 ]
558508 ugt1b1; UDP glucuronosyltransferase 1 family, polypeptide B1 precursor [KO:K00699 ] [EC:2.4.1.17 ]
570913 ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 precursor [KO:K00699 ] [EC:2.4.1.17 ]
641479 ugt5a1; UDP glucuronosyltransferase 5 family, polypeptide A1 precursor [KO:K00699 ] [EC:2.4.1.17 ]
64607 alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643 ] [EC:2.3.1.37 ]
678597 ugt5b6; UDP glucuronosyltransferase 5 family, polypeptide B6 precursor [KO:K00699 ] [EC:2.4.1.17 ]
751732 ears2; nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial isoform 2 precursor [KO:K01885 ] [EC:6.1.1.17 ]
767705 ugt2a5; UDP glucuronosyltransferase 2 family, polypeptide A5 precursor [KO:K00699 ] [EC:2.4.1.17 ]
767756 ugt5a2; UDP glucuronosyltransferase 5 family, polypeptide A2 precursor [KO:K00699 ] [EC:2.4.1.17 ]
791210 ugt5b4; UDP glucuronosyltransferase 5 family, polypeptide B4 precursor [KO:K00699 ] [EC:2.4.1.17 ]
791613 ugt2a4; UDP glucuronosyltransferase 2 family, polypeptide A4 precursor [KO:K00699 ] [EC:2.4.1.17 ]
792506 ugt2b6; UDP glucuronosyltransferase 2 family, polypeptide B6 precursor [KO:K00699 ] [EC:2.4.1.17 ]
795261 ugt1b7; UDP glucuronosyltransferase 1 family, polypeptide B7 precursor [KO:K00699 ] [EC:2.4.1.17 ]
Compound C03373 Aminoimidazole ribotide
C03516 Magnesium protoporphyrin
C03741 (S)-4-Amino-5-oxopentanoate
C04122 D-1-Aminopropan-2-ol O-phosphate
C04536 Magnesium protoporphyrin monomethyl ester
C04778 N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
C05787 Bilirubin beta-diglucuronide
C06503 Hydrogenobyrinate a,c diamide
C06504 Cob(II)yrinate a,c diamide
C06505 Cob(I)yrinate a,c diamide
C06506 Adenosyl cobyrinate a,c diamide
C06507 Adenosyl cobyrinate hexaamide
C06509 Adenosyl cobinamide phosphate
C06510 Adenosine-GDP-cobinamide
C11538 Cobalt-sirohydrochlorin
C11543 Cobalt-dihydro-precorrin 6
C11630 15,16-Dihydrobiliverdin
C11829 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester
C11830 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester
C11831 Divinylprotochlorophyllide
C11832 Divinyl chlorophyllide a
C11851 Zn-Bacteriochlorophyll a
C12147 L-Threonine O-3-phosphate
C16540 7(1)-Hydroxychlorophyllide a
C18022 Red chlorophyll catabolite
C18098 Primary fluorescent chlorophyll catabolite
C18151 7(1)-Hydroxychlorophyll a
C18152 3-Vinylbacteriochlorophyllide a
C18153 3-Hydroxyethylbacteriochlorophyllide a
C18154 3-Hydroxyethylchlorophyllide a
C18155 Bacteriochlorophyllide a
C18156 Bacteriochlorophyllide b
C18157 8-Ethyl-12-methyl-3-vinylbacteriochlorophyllide d
C18160 Bacteriochlorophyllide d
C18161 Bacteriochlorophyllide c
C21217 Geranylgeranyl bacteriochlorophyllide a
C21427 8,12-Diethyl-3-vinylbacteriochlorophyllide d
C21428 12-Ethyl-8-propyl-3-vinylbacteriochlorophyllide d
C21429 12-Ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d
C21431 8-Ethyl-12-methylbacteriochlorophyllide d
C21432 8,12-Diethylbacteriochlorophyllide d
C21433 12-Ethyl-8-propylbacteriochlorophyllide d
C21434 12-Ethyl-8-isobutylbacteriochlorophyllide d
C21435 Geranylgeranyl bacteriochlorophyllide b
C21510 Nickel-sirohydrochlorin
C21511 Nickel-sirohydrochlorin a,c-diamide
C21512 15,17(3)-Seco-F430-17(3)-acid
C21582 Bacteriochlorophyllide e
C21835 12,18-Didecarboxysiroheme
C22451 5-Methoxy-6-methylbenzimidazole
Reference Authors Woodcock SC, Raux E, Levillayer F, Thermes C, Rambach A, Warren MJ.
Title Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis.
Journal Reference Authors Johansson P, Hederstedt L
Title Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria.
Journal Reference Authors Maggio-Hall LA, Escalante-Semerena JC.
Title In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes.
Journal Reference Authors Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ.
Title The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway.
Journal Reference Authors Scott AI, Roessner CA.
Title Biosynthesis of cobalamin (vitamin B(12)).
Journal Reference Authors Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title The biosynthesis of adenosylcobalamin (vitamin B12).
Journal Reference Authors Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI.
Title Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii).
Journal Reference Authors Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
Title Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
Journal Reference Authors Chew AG, Bryant DA
Title Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity.
Journal Reference Authors Frigaard NU, Chew AG, Li H, Maresca JA, Bryant DA
Title Chlorobium tepidum: insights into the structure, physiology, and metabolism of a green sulfur bacterium derived from the complete genome sequence.
Journal Reference Authors Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ
Title An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
Journal Reference Authors Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ
Title Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
Journal Related dre00250 Alanine, aspartate and glutamate metabolism
dre00260 Glycine, serine and threonine metabolism
KO pathway
